Abstract: Described herein are functional cell assays and methods for selecting a personalized anti-cancer treatment regimen that can improve treatment of cancer in a subject, identify resistance of the subject's cancer to one or more anti-cancer agents and/or validate the current drug treatment strategy.

Abstract: Compositions, targeting reagents, modified cells, nucleic acid molecules, systems, and methods for identifying and selecting genomic safe harbor sites for transgene insertion and other genome engineering applications. These materials and methods can be used to develop desired genome engineering applications, such as transgene insertion and expression or genome modification, that take into account the application-specific needs for safety, functional silence, and accessibility and other factors that vary with a desired application's goals and target population. Representative examples of desired genome engineering applications include, but are not limited to, transgene insertion, such as therapeutic transgene insertion, functional gene editing, gene or chromosomal location-specific structural modification, cell marking, gene activation, and/or gene repression.

Abstract: Methods and microfluidic apparatus are disclosed for drug prediction. A microfluidic apparatus has (a) a plate, (b) a plurality of wells defined in the plate, (c) a plurality of closed microchannels defined in the plate, and (d) a sample platform defining a plurality of open microchannels, where the plurality of closed microchannels are each in communication with one of the plurality of wells and one of the plurality of open microchannels of the sample platform.

Abstract: Methods and microfluidic apparatus are disclosed for drug prediction. A microfluidic apparatus has (a) a plate, (b) a plurality of wells defined in the plate, (c) a plurality of closed microchannels defined in the plate, and (d) a sample platform defining a plurality of open microchannels, where the plurality of closed microchannels are each in communication with one of the plurality of wells and one of the plurality of open microchannels of the sample platform.