Patents by Inventor Raymond J. Pierce
Raymond J. Pierce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8124026Abstract: Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.Type: GrantFiled: March 5, 2010Date of Patent: February 28, 2012Assignee: Epocal Inc.Inventors: Imants Lauks, Raymond J. Pierce, James Wojtyk, Benoit R. Bergevin
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Publication number: 20100202926Abstract: Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.Type: ApplicationFiled: March 5, 2010Publication date: August 12, 2010Applicant: EPOCAL INC.Inventors: Imants LAUKS, Raymond J. PIERCE, James WOJTYK, Benoit R. BERGEVIN
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Patent number: 7722817Abstract: Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.Type: GrantFiled: August 28, 2003Date of Patent: May 25, 2010Assignee: Epocal Inc.Inventors: Imants Lauks, Raymond J. Pierce, James Wojtyk, Benoit R. Bergevin
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Patent number: 7201833Abstract: The invention is directed to analytical devices and micro-arrays with integral fluidic inputs and outputs. The devices are constructed from planar solid-phase hydrophilic matrix circuits containing dry chemical reagents overlaying integral electro-kinetic pumping electrodes. The hydrophilic matrix circuits are enclosed within a gas permeable electrical insulator. The devices are for use in micro-scale bio-analysis, mixture separation and reaction.Type: GrantFiled: December 2, 2002Date of Patent: April 10, 2007Assignee: Epocal Inc.Inventors: Imants Lauks, Raymond J. Pierce, James Wojtyk, Benoit R. Bergevin
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Publication number: 20030127333Abstract: The invention is directed to analytical devices and micro-arrays with integral fluidic inputs and outputs. The devices are constructed from planar solid-phase hydrophilic matrix circuits containing dry chemical reagents overlaying integral electro-kinetic pumping electrodes. The hydrophilic matrix circuits are enclosed within a gas permeable electrical insulator. The devices are for use in micro-scale bio-analysis, mixture separation and reaction.Type: ApplicationFiled: December 2, 2002Publication date: July 10, 2003Inventors: Imants Lauks, Raymond J. Pierce, James Wojtyk, Benoit R. Bergevin
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Patent number: 6379883Abstract: A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.Type: GrantFiled: December 21, 2000Date of Patent: April 30, 2002Assignee: i-STAT CorporationInventors: Graham Davis, Chao Lin, Imants R. Lauks, Raymond J. Pierce
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Publication number: 20010003045Abstract: A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.Type: ApplicationFiled: December 21, 2000Publication date: June 7, 2001Inventors: Graham Davis, Chao Lin, Imants R. Lauks, Raymond J. Pierce
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Patent number: 6030827Abstract: A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer to allow controlled analyte flux to the diffusion layer.Type: GrantFiled: January 23, 1998Date of Patent: February 29, 2000Assignee: i-Stat CorporationInventors: Graham Davis, Chao Lin, Imants R. Lauks, Raymond J. Pierce
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Patent number: 5789253Abstract: An apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the concentration of a dissolved gas in a fluid sample. In one embodiment, the method is used to control the equilibrated gas composition of a calibrant fluid which, in turn, is used to measure the concentration of a dissolved gas, such as oxygen and carbon dioxide, in a sample fluid, such as whole blood.Type: GrantFiled: March 10, 1997Date of Patent: August 4, 1998Assignee: i-Stat CorporationInventors: Imants R. Lauks, Raymond J. Pierce, Joseph W. Rogers, Michael P. Zelin
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Patent number: 5614416Abstract: Disclosed is an apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the concentration of a dissolved gas in a fluid sample. In one embodiment, the disclosed method is used to control the equilibrated gas composition of a calibrant fluid which, in turn, is used to measure the concentration of a dissolved gas, such as oxygen and carbon dioxide, in a sample fluid, such as whole blood.Type: GrantFiled: October 23, 1995Date of Patent: March 25, 1997Assignee: I-Stat CorporationInventors: Imants R. Lauks, Raymond J. Pierce, Joseph W. Rogers, Michael P. Zelin
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Patent number: 5609824Abstract: Disclosed is an apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the concentration of a dissolved gas in a fluid sample. In one embodiment, the disclosed method is used to control the equilibrated gas composition of a calibrant fluid which, in turn, is used to measure the concentration of a dissolved gas, such as oxygen and carbon dioxide, in a sample fluid, such as whole blood.Type: GrantFiled: July 13, 1994Date of Patent: March 11, 1997Assignee: i-Stat CorporationInventors: Imants R. Lauks, Raymond J. Pierce, Joseph W. Rogers, Michael P. Zelin
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Patent number: 5605664Abstract: Disclosed is an apparatus and method of equilibrating the dissolved gas composition of an aqueous fluid to reflect the predetermined gas composition contained in a gas equilibration reservoir. The equilibrated aqueous fluid can be used in a method of determining the concentration of a dissolved gas in a fluid sample. In one embodiment, the disclosed method is used to control the equilibrated gas composition of a calibrant fluid which, in turn, is used to measure the concentration of a dissolved gas, such as oxygen and carbon dioxide, in a sample fluid, such as whole blood.Type: GrantFiled: October 23, 1995Date of Patent: February 25, 1997Assignee: i-STAT CorporationInventors: Imants R. Lauks, Raymond J. Pierce, Joseph W. Rogers, Michael P. Zelin
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Patent number: 5514253Abstract: A microfabricated sensing device is disclosed, including methods for using the same for the measurement of the concentration of a gas in a sample. Unique sensor configurations are described which substantially eliminate electrode cross-contamination during operation of the microfabricated sensing devices.Type: GrantFiled: July 13, 1994Date of Patent: May 7, 1996Assignee: I-Stat CorporationInventors: Graham Davis, Imants R. Lauks, Raymond J. Pierce, Cindra A. Widrig