Abstract: A device for dispensing a metered dose of fluid is provided. The device comprises a housing comprising: a non-pressurised reservoir sized to accommodate a plurality of doses of fluid; a springloaded metering chamber sized to hold at least a single dose of fluid; a first valve enabling fluid communication between the reservoir and the metering chamber; and a kink valve enabling the fluid in the metering chamber to exit the device.

Abstract: A system for dispensing pills may include a plurality of containers, a retrieval arm movable into the plurality of containers to retrieve contents from the plurality of containers, a carrier supporting the plurality of containers, the carrier movable to adjust positions of the plurality of containers relative to a predetermined position, and a weighing assembly. The weighing assembly may include an actuator and a weight sensor. The actuator may be actuatable to control mechanical communication between the weight sensor and one of the plurality of containers at the predetermined position, and the weight sensor may be operable to measure weight of the one of the plurality of containers in mechanical communication with the weight sensor at the predetermined position.

Abstract: The invention relates to the use of a wetting composition comprising (a) from 20 to less than 50 wt % of one or more C10 to C14 alcohol, (b) 25 to 70 wt % of a surfactant selected from a non-ionic, cationic, anionic and amphoteric surfactant, and (c) from 5 to 50 wt % of a polar component comprising at least one selected from (i) water, and (ii) up to 25 wt % of a water-miscible C1-C3 organic solvent in lowering the surface tension of non-aqueous liquids, to methods for using the wetting composition, and products and non-aqueous compositions containing the wetting composition.

Abstract: An apparatus is arranged to heat smokable material to volatilize at least one component of the smokable material. In one exemplary embodiment, the apparatus has a housing and a plurality of heater segments longitudinally arranged within the housing for heating smokable material contained within the apparatus. At least one heater segment is arranged so as to heat smokable material contained within the at least one heater segment more quickly than at least one other heater segment heats smokable material contained within the at least one other heater segment.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: A container for collecting liquid for transport, includes a shell having a port adapted for receiving tubing and configured to define a chamber that has a window in an exterior surface of the shell. The window is so positioned that when a wicking material, which is adapted to be applied against a particular source of moisture and which is so dimensioned that when the wicking material is received within the shell and applied through the window to the particular source of moisture, the shell is at least partially closed so that when tubing is inserted through the port into the shell chamber and the shell is otherwise closed a partial vacuum can be created within the shell chamber to draw moisture into the shell chamber through the wicking material for collection as a liquid within the shell chamber for transport from the shell chamber via the tubing.

Abstract: A conveyor roller including a monitoring/sensing device includes a sensor, a processor, an identification device, and a transmitter. The sensor is configured to sense at least one characteristic of said conveyor roller and to produce sensor data representative of said sensed characteristic. The processor is configured to determine when a predetermined abnormal characteristic is sensed. The identification device is configured to provide unique identification data for the conveyor roller. The transmitter is configured to only transmit said data when said predetermined abnormal characteristic is sensed.

Abstract: A container for collecting liquid for transport, includes a shell having a port adapted for receiving tubing and configured to define a chamber that has a window in an exterior surface of the shell. The window is so positioned that when a wicking material, which is adapted to be applied against a particular source of moisture and which is so dimensioned that when the wicking material is received within the shell and applied through the window to the particular source of moisture, the shell is at least partially closed so that when tubing is inserted through the port into the shell chamber and the shell is otherwise closed a partial vacuum can be created within the shell chamber to draw moisture into the shell chamber through the wicking material for collection as a liquid within the shell chamber for transport from the shell chamber via the tubing.

Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, X, n1, n2, and n3 are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.

Abstract: A system and method for employing centrifugal confinement fusion for in-space propulsion and power generation is disclosed. Centrifugal confinement represents an advancement beyond traditional mirror devices by further confining the fusion fuel and inhibiting instability growth, while still offering a simple magnet geometry and allowing a controllable fraction of the charged fusion products to leave each end of the mirror. These charged products are used to directly heat a higher mass flow rate, lower temperature propellant in the aft direction, which is then expanded through a magnetic nozzle to produce thrust. The lower temperature of the exhaust flow supports an increased level of collisionality to promote plume detachment, and the level of thrust can be traded against specific impulse for mission optimization. Power from the forward flowing charged species is directly converted to electricity to help drive the rotating plasma.

Abstract: The present disclosure generally relates to pharmaceutical compositions and combinations comprising an androgen receptor N-terminal domain inhibitor or an inhibitor and a second therapeutically active agent, such as an CDK4/6 inhibitor, a Pin1 inhibitor (inhibitor of peptidyl-prolyl cis/trans isomerases), or an antiandrogen. In particular, the present disclosure relates to pharmaceutical compositions and combinations useful for treatment of various cancers, for example breast cancer and prostate cancer. Further, the present disclosure relates administering an androgen receptor N-terminal domain inhibitor in combination with radiation therapy for treatment of various cancers.

Abstract: Systems and methods for determining and displaying an average or median count of mobile devices near an entity location is described. The systems and methods comprise receiving location data from a plurality of mobile devices to determine their locations over a period of time. An average or median count of mobile devices of the plurality of mobile devices that are within a threshold distance from an entity during individual hours of a plurality of hours of a day is determined. The highest average or median count of mobile devices during the plurality hours of a day is set as a benchmark count. A user interface is presented that includes a plurality of graphical representations individually corresponding to respective hours of the plurality of hours and a visual indication of the average or median count for the respective hour relative to the benchmark count.

Abstract: Provided herein are modified polyhydroxyalkanoates and methods of making the same. The modified polyhydroxyalkanoates are made via thermolysis of a polyhydroxyalkanoate and a plant-based acid acting as a nucleophile.

Abstract: Systems and methods comprising determining a first user in proximity to a point of sale (POS) device of a second user, the POS device having detected an identity of the first user and a number of devices associated with the POS device. The number of devices is compared to a baseline number of devices in proximity to the POS device, which is based on a time of day and calculated from a time period prior to the time of day. Based on a determination that the number differs from the baseline number by more than a threshold amount, data is generated that includes an indication configured to be displayed utilizing a client application executing on a device of the first user, wherein user interaction with the indication enables the user to at least one of initiate or modify a transaction with the second user.

Abstract: Methods and compositions comprising primers and probes to detect nucleic acids are provided. The probes comprise a ribonucleotide that can be cleaved by an RNase H2 enzyme when the probe is annealed to a reverse complement of a universal sequence that is introduced to a target nucleic acid, for example via amplification.

Abstract: The invention relates to the use of a wetting composition comprising (a) from 20 to less than 50 wt % of one or more C10 to C14 alcohol, (b) 25 to 70 wt % of a surfactant selected from a non-ionic, cationic, anionic and amphoteric surfactant, and (c) from 5 to 50 wt % of a polar component comprising at least one selected from (i) water, and (ii) up to 25 wt % of a water-miscible C1-C3 organic solvent in lowering the surface tension of non-aqueous liquids, to methods for using the wetting composition, and products and non-aqueous compositions containing the wetting composition.

Abstract: An optical fibre assembly comprises a hollow core optical waveguide comprising a hollow core surrounded by a structured arrangement of longitudinally extending capillaries providing an inner cladding surrounded by an outer cladding; a diagnostic solid core optical waveguide comprising a solid core surrounded by a cladding, and extending substantially parallel to the hollow core optical waveguide; and a jacket surrounding both the hollow core optical waveguide and the solid core optical waveguide and forming a common mechanical environment for the hollow core optical waveguide and the solid core optical waveguide. The optical fibre assembly may be or may comprise or be included in an optical fibre cable, and may be used in a method for testing hollow core optical waveguides.

Abstract: The invention relates to the use of a wetting composition comprising a surfactant selected from a non-ionic, cationic, anionic and amphoteric surfactant in combination with from 10 to less than 50 wt % of at least one C10 to C14 alcohol and 10 to 30 wt % of a C4-C6 oxygen containing co-solvent in lowering the surface tension of non-aqueous liquids, to methods for using the wetting composition, and products including non-aqueous compositions containing the wetting composition.

Abstract: A method of extracting a substance comprising the steps of: placing a substrate on which a substance has been adsorbed into a container; feeding a solvent into the container whilst restricting its exit to achieve a predetermined pressure of the solvent in the container, wherein the solvent has a critical point and the predetermined pressure is above the critical point of the solvent; releasing the solvent and an extract comprising extracted substances into a separator; reducing the temperature and pressure in the separator to remove a gaseous portion of the solvent from the extract; collecting the extract remaining from the separator.

Abstract: In general, this disclosure describes techniques for applying a distributed pipeline model in a distributed computing system to cause processing nodes of the distributed computing system to process data according to a distributed pipeline having an execution topology, specified within a pipeline statement, to perform a task.