Abstract: The present disclosure provides methods of obtaining, recovering and culturing pulmonary arterial endothelial cells from an individual patient subjected to a right heart catheterization in regard to diagnosis of pulmonary hypertension. These isolated pulmonary arterial endothelial cells from an individual patient may be utilized to generate cellular phenotyping profile for the cell population, allowing generation of a personalized pharmacotherapy regime to assist the clinician in treatment and prognosis of the disorder for an individual patient.

Abstract: The present disclosure provides methods of obtaining, recovering and culturing pulmonary arterial endothelial cells from an individual patient subjected to a right heart catheterization in regard to diagnosis of pulmonary hypertension. These isolated pulmonary arterial endothelial cells from an individual patient may be utilized to generate cellular phenotyping profile for the cell population, allowing generation of a personalized pharmacotherapy regime to assist the clinician in treatment and prognosis of the disorder for an individual patient.

Abstract: The present disclosure provides methods of obtaining, recovering and culturing pulmonary arterial endothelial cells from an individual patient, subjected to a right heart catheterization in regard to diagnosis of pulmonary hypertension. These isolated pulmonary arterial endothelial cells from an individual patient may be utilized to generate cellular phenotyping profile for the cell population, allowing generation of a personalized pharmacotherapy regime to assist the clinician in treatment and prognosis of the disorder for an individual patient.

Abstract: A method of and system for determining ventricular ejection fraction of a patient is provided. A pressure sensing device captures pulmonary arterial pressure data for a patient over time. A processing device receives the pressure data, generates a first time-resolved pressure curve, displaces the pressure values of the first time-resolved curve at least one time point and subtracts the displaced pressure values from the received pressure data to form a second time-resolved pressure curve so that the second curve has two or more distinct pulses from which an initial pulse may be isolated and an area may be calculated. The processing device determines an average pressure by averaging the pressure data of the first curve over a cardiac cycle of data; determines a cardiac chamber stroke volume for the patient; and uses the determined cardiac chamber stroke volume and determined average pressure to determine an ejection fraction for the patient.

Abstract: The present disclosure provides methods of obtaining, recovering and culturing pulmonary arterial endothelial cells from an individual patient, subjected to a right heart catheterization in regard to diagnosis of pulmonary hypertension. These isolated pulmonary arterial endothelial cells from an individual patient may be utilized to generate cellular phenotyping profile for the cell population, allowing generation of a personalized pharmacotherapy regime to assist the clinician in treatment and prognosis of the disorder for an individual patient.

Abstract: This invention to provides means of achieving cardiovascular protective effects by administration of fibrinolytic activity increasing amounts of catechin, epicatechin, quercetin and/or resveratrol or their complexes individually or in combination without administration of ethanol.