Patents by Inventor Raymond L. Mernaugh
Raymond L. Mernaugh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9745377Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.Type: GrantFiled: May 5, 2015Date of Patent: August 29, 2017Assignee: VANDERBILT UNIVERSITYInventors: Paula R. Pohlmann, Raymond L. Mernaugh, Carlos L. Arteaga
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Publication number: 20160053010Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.Type: ApplicationFiled: May 5, 2015Publication date: February 25, 2016Inventors: Paula R. POHLMANN, Raymond L. MERNAUGH, Carlos L. ARTEAGA
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Patent number: 9023362Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.Type: GrantFiled: July 16, 2013Date of Patent: May 5, 2015Assignee: Vanderbilt UniversityInventors: Paula R. Pohlmann, Raymond L. Mernaugh
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Patent number: 8920729Abstract: A sensor for sensing at least one biological target or chemical target is provided. The sensor includes a membrane includes a membrane material that supports generation and propagation of at least one waveguide mode, where the membrane material includes a plurality of voids having an average size <2 microns. The sensor also includes at least one receptor having structure for binding to the target within the plurality of voids, and an optical coupler for coupling light to the membrane sufficient to generate the waveguide mode in the membrane from photons incident on the optical coupler.Type: GrantFiled: June 18, 2013Date of Patent: December 30, 2014Assignee: Vanderbilt UniversityInventors: Guoguang Rong, Sharon M. Weiss, Raymond L. Mernaugh
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Publication number: 20140086905Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.Type: ApplicationFiled: July 16, 2013Publication date: March 27, 2014Applicant: VANDERBILT UNIVERSITYInventors: Paula R. POHLMANN, Raymond L. MERNAUGH
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Publication number: 20130280796Abstract: A sensor for sensing at least one biological target or chemical target is provided. The sensor includes a membrane includes a membrane material that supports generation and propagation of at least one waveguide mode, where the membrane material includes a plurality of voids having an average size <2 microns. The sensor also includes at least one receptor having structure for binding to the target within the plurality of voids, and an optical coupler for coupling light to the membrane sufficient to generate the waveguide mode in the membrane from photons incident on the optical coupler.Type: ApplicationFiled: June 18, 2013Publication date: October 24, 2013Applicant: VANDERBILT UNIVERSITYInventors: Guoguang Rong, Sharon M. Weiss, Raymond L. Mernaugh
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Patent number: 8506887Abstract: A sensor for sensing at least one biological target or chemical target is provided. The sensor includes a membrane includes a membrane material that supports generation and propagation of at least one waveguide mode, where the membrane material includes a plurality of voids having an average size<2 microns. The sensor also includes at least one receptor having structure for binding to the target within the plurality of voids, and an optical coupler for coupling light to the membrane sufficient to generate the waveguide mode in the membrane from photons incident on the optical coupler.Type: GrantFiled: October 16, 2009Date of Patent: August 13, 2013Assignee: Vanderbilt UniversityInventors: Guoguang Rong, Raymond L. Mernaugh, Sharon M. Weiss
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Patent number: 8486413Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.Type: GrantFiled: December 8, 2011Date of Patent: July 16, 2013Assignee: Vanderbilt UniversityInventors: Paula R. Pohlmann, Raymond L. Mernaugh, Carlos L. Arteaga
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Publication number: 20120201820Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.Type: ApplicationFiled: December 8, 2011Publication date: August 9, 2012Inventors: Paula R. Pohlmann, Raymond L. Mernaugh, Carlos L. Arteaga
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Patent number: 8148170Abstract: An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as Staphylococcus aureus having protein A or protein G.Type: GrantFiled: February 10, 2011Date of Patent: April 3, 2012Assignees: Oakland University, Vanderbilt UniversityInventors: Xiangqun Zeng, Raymond L. Mernaugh
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Publication number: 20110201032Abstract: An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as Staphylococcus aureus having protein A or protein G.Type: ApplicationFiled: February 10, 2011Publication date: August 18, 2011Applicants: Oakland University, Vanderbilt UniversityInventors: Xiangqun Zeng, Raymond L. Mernaugh
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Patent number: 7888134Abstract: An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as Staphylococcus aureus having protein A or protein G.Type: GrantFiled: August 6, 2007Date of Patent: February 15, 2011Assignees: Oakland University, Vanderbilt UniversityInventors: Xiangqun Zeng, Raymond L. Mernaugh
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Publication number: 20100098592Abstract: A sensor for sensing at least one biological target or chemical target is provided. The sensor includes a membrane includes a membrane material that supports generation and propagation of at least one waveguide mode, where the membrane material includes a plurality of voids having an average size<2 microns. The sensor also includes at least one receptor having structure for binding to the target within the plurality of voids, and an optical coupler for coupling light to the membrane sufficient to generate the waveguide mode in the membrane from photons incident on the optical coupler.Type: ApplicationFiled: October 16, 2009Publication date: April 22, 2010Applicant: Vanderbilt UniversityInventors: Guoguang Rong, Raymond L. Mernaugh, Sharon M. Weiss
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Publication number: 20080171346Abstract: An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule specific for the analyte of interest, having one or more amino acids with charged or hydrogen-bond forming sidechains in a linker polypeptide portion, is bound to the layer on the solid substrate. When the analyte of interest is present in the sample the scFv binds the analyte to the solid substrate. The apparatus can be used with an immunoglobulin layer to detect Fc receptors, so as to detect microorganisms such as Staphylococcus aureus having protein A or protein G.Type: ApplicationFiled: August 6, 2007Publication date: July 17, 2008Applicants: Oakland UniversityInventors: Xiangqun Zeng, Raymond L. Mernaugh
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Patent number: 7329536Abstract: An apparatus comprising one or more piezoelectric mass sensors for use in diagnostic and analytic processes, in particular for immunochemical detection of diagnostically relevant analytes in real time, is described. Each piezoelectric mass sensor comprises a piezoelectric crystal with a receptor surface which has immobilized thereon a lawn of recombinant antibodies comprising single VH chain or single-chain Fv (scFv) polypeptides specific for a particular antigen. Binding of antigen to the recombinant antibodies results in a change in mass on the receptor surface which is detected as a change in resonant frequency. In a preferred embodiment, the receptor layer is a precious metal such as gold which facilitates self-assembly of the recombinant antibodies into a lawn on the receptor surface via a cysteine residue at the carboxy terminus of the attachment polypeptide.Type: GrantFiled: June 4, 2004Date of Patent: February 12, 2008Assignees: Oakland University, Vanderbilt UniversityInventors: Xiangqun Zeng, Gabrielle Stryker, Raymond L. Mernaugh