Patents by Inventor Raymond L. White
Raymond L. White has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20030170638Abstract: Methods are disclosed for predicting family and individual genetic risk of disease through the analysis of very large families (VLFs). A predetermined founder is identified. The definition of family is broadened to include about 100 or more decedents from the founder. The VLF can then be linked to a disease registry to determine if there is a significant excess of disease. This method can further identify individuals at risk for disease. The identified individuals and their immediate family members can then provide DNA samples. These samples can be used to identify the susceptibility gene.Type: ApplicationFiled: March 7, 2002Publication date: September 11, 2003Inventors: Raymond L. White, Richard Kerber
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Patent number: 6413727Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.Type: GrantFiled: May 25, 1995Date of Patent: July 2, 2002Assignees: The Johns Hopkins University, University of Utah, Japanese Foundation for Cancer Research Cancer Institute, Zeneca LimitedInventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
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Patent number: 6114124Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.Type: GrantFiled: May 25, 1995Date of Patent: September 5, 2000Assignees: The Johns Hopkins University, University of Utah, The Cancer Institute, Imperial Chemical Industries PLCInventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
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Patent number: 5876940Abstract: The present invention relates to a functional screen assay for nonsense or frameshift mutations that allows genes of interest to be scanned. This assay is based on the cloning of segments of the gene of interest in-frame with a sequence coding for a marker followed by screening for the level of expression of the marker. Individuals at risk for any one of a number of genetic diseases, which are associated with such nonsense or frameshift mutations, can be quickly screened for chain-terminating mutations introduced by these nonsense and frameshift mutations. At present, scanning of many genes for mutations requires significant effort because the genes are large and most mutations are unique. Therefore, this assay offers a powerful option for the diagnosis of many genetic diseases.Type: GrantFiled: June 2, 1997Date of Patent: March 2, 1999Assignee: University of Utah Research FoundationInventors: Joanna L. Groden, Raymond L. White, Lisa Spirio, Margaret Robertson, Robert Weiss, Therese Tuohy
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Patent number: 5783666Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.Type: GrantFiled: May 25, 1995Date of Patent: July 21, 1998Assignees: The Johns Hopkins University, The University of Utah, Zeneca Pharmaceuticals, The Cancer InstituteInventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
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Patent number: 5691454Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.Type: GrantFiled: May 25, 1995Date of Patent: November 25, 1997Assignees: The Johns Hopkins University, University of Utah, the Cancer Institute, Imperial Chemical Industries PLCInventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Fred Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
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Patent number: 5648212Abstract: Methods are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. APC is a tumor suppressor.Type: GrantFiled: August 12, 1994Date of Patent: July 15, 1997Assignees: The John Hopkins University, University of Utah, Japanese Foundation for Cancer Research Cancer Institute, Zeneca LimitedInventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
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Patent number: 5605799Abstract: The present invention is directed to somatic mutations of the NF1 gene which are found in human tumors. In addition, the present invention is directed to methods of screening humans to determine those having somatic mutations in the NF1 gene in tumors. Finally, the invention is directed to a method of treating a human having a tumor with a somatic mutation in the NF1 gene by restoring natural regulation of ras proteins.Type: GrantFiled: March 28, 1995Date of Patent: February 25, 1997Assignee: University of Utah Research FoundationInventors: Raymond L. White, Richard M. Cawthon, Ying Li
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Patent number: 5484915Abstract: A substituted phthalocyanine in which at least one of the peripheral carbon atoms in the 1-16 positions of the phthalocyanine nucleus (MnPc) as shown in Formula (1) ##STR1## is linked via an oxygen atom or a sulphur atom to an organic radical, the remaining peripheral carbon atoms being unsubstituted or substituted by any combination of atoms or groups and sulphonated derivatives thereof. Compositions comprising one or more compounds of Formula (1) and their use as cleaning materials are also disclosed along with a process for removing stains and/or grime from fabrics using these compositions.Type: GrantFiled: July 6, 1994Date of Patent: January 16, 1996Assignee: Zeneca LimitedInventors: Peter Gregory, Stephen J. Reynolds, Raymond L. White
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Patent number: 5417778Abstract: A light weight, high strength quaternary or higher-order cast beryllium-aluminum alloy, including approximately 60 to 70 weight % beryllium, and from approximately 0.2 to 5 weight % germanium and from 0.2 to 4.25 weight % silver, with the balance aluminum. Beryllium strengthening elements selected from the group consisting of copper, nickel, or cobalt may be present at from 0.1 to 5.0 weight % of the alloy to increase the alloy strength.Type: GrantFiled: January 26, 1994Date of Patent: May 23, 1995Assignee: Nuclear Metals, Inc.Inventors: William T. Nachtrab, Nancy F. Levoy, Raymond L. White, III
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Patent number: 5411859Abstract: The present invention is related to the identification of cloned DNA sequences that reveal individual multiallele loci. The loci are used in the process of the present invention to provide convenient and accurate genetic identification. A large number of clones that recognize VNTR loci have been isolated from a cosmid library and characterized.Type: GrantFiled: June 10, 1991Date of Patent: May 2, 1995Assignee: University of Utah Research FoundationInventors: Raymond L. White, Yusuke Nakamura, Peter O'Connell, Midvale, Mark F. Leppert
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Patent number: 5352775Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.Type: GrantFiled: August 8, 1991Date of Patent: October 4, 1994Assignees: The Johns Hopkins Univ., The Univ. of Utah, Imperial Chemical Industries, Cancer InstituteInventors: Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip J. Hedge, Geoff Joslyn, Kenneth Kinzler, Alexander F. Markham, Yusuke Nakamura, Andrew Thliveris, Bert Vogelstein, Raymond L. White
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Patent number: 5227292Abstract: The present invention relates to the neurofibromatosis type 1 (NF1) gene and its gene product. The invention further relates to methods for the detection in and treatment of humans having defective NF1 genes and for detection of tumors caused by a defective NF1 gene.Type: GrantFiled: July 12, 1990Date of Patent: July 13, 1993Assignee: University of UtahInventors: Raymond L. White, Peter O'Connell, David H. Viskochil, Richard M. Cawthon
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Patent number: 4963663Abstract: The present invention is related to the identification of cloned DNA sequences that reveal individual multiallele loci. The loci are used in the process of the present invention to provide convenient and accurate genetic identification. A large number of clones that recognize VNTR loci have been isolated from a cosmid library and characterized.Type: GrantFiled: February 8, 1989Date of Patent: October 16, 1990Assignee: University of UtahInventors: Raymond L. White, Yusuke Nakamura, Peter O'Connell, Mark F. Leppert
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Patent number: 4764178Abstract: A thermal transfer printing sheet comprising a substrate having a coating comprising at least one azo dye of the formula:A--N.dbd.N--E Iwherein:A is the residue of a diazotizable heteroaromatic amine, A--NH.sub.2, in which A is selected from imidazolyl, pyrazolyl, thiazolyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, pyridoisothiazolyl and thienyl; andE is the residue of an aromatic coupling component, E--X wherein X is a group displaceable by a diazotized aromatic amine and E is optionally substituted aminophenyl, tetrahydroquinolinyl, julolidyl or aminoquinolinyl,and a process for the transfer of dye from the transfer sheet to a receiver sheet by the selective application of heat to the transfer sheet while it is contact with the receiver sheet.Type: GrantFiled: August 13, 1986Date of Patent: August 16, 1988Assignee: Imperial Chemical Industries PLCInventors: Peter Gregory, Raymond L. White
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Patent number: RE38916Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.Type: GrantFiled: November 18, 1999Date of Patent: December 6, 2005Assignees: The Johns Hopkins University, The University of Utah, The Cancer Institute, Zeneca LimitedInventors: Bert Vogelstein, Kenneth W. Kinzler, Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip John Hedge, Geoff Joslyn, Alexander Fred Markham, Yusuka Nakamura, Andrew Thilveris, Raymond L. White
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Patent number: RE36357Abstract: A thermal transfer printing sheet comprising a substrate having a coating comprising at least one azo dye of the formula:A--N.dbd.N--E Iwherein :A is the residue of a diazotizable heteroaromatic amine, A--NH.sub.2, in which A is selected from imidazolyl, pyrazolyl, thiazolyl, benzothiazolyl, isothiazolyl, benzoisothiazolyl, pyridoisothiazolyl and thienyl; andE is the residue of an aromatic coupling component, E--X wherein X is a group displaceable by a diazotized aromatic amine and E is optionally substituted aminophenyl, tetra- hydroquinolinyl, julolidyl or aminoquinolinyl,and a process for the transfer of dye from the transfer sheet to a receiver sheet by the selective application of heat to the transfer sheet while it is contact with the receiver sheet.Type: GrantFiled: July 5, 1990Date of Patent: October 26, 1999Assignee: Imperial Chemical Industries PLCInventors: Peter Gregory, Raymond L. White