Patents by Inventor Raymond Liu
Raymond Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11951906Abstract: Systems and methods for deploying emergency roadside signaling devices are disclosed. In one aspect, system for an autonomous vehicle includes one or more signaling devices configured to visually notify other vehicles when placed on or near a roadway, and an object placing device configured to place the one or more signaling devices. The system further includes a processor and a computer-readable memory in communication with the processor and having stored thereon computer-executable instructions to cause the processor to: determine that the autonomous vehicle has experienced a malfunction, and provide instructions to the object placing device to place the one or more signaling devices on or near the roadway.Type: GrantFiled: June 22, 2021Date of Patent: April 9, 2024Assignee: TuSimple, Inc.Inventors: Charles A Price, Todd B. Skinner, Juexiao Ning, Yishi Liu, Qiwei Li, Raymond Alan Thomas, Alan Camyre, Jim Giglio, Robert Patrick Brown
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Patent number: 11945367Abstract: Systems and methods for deploying emergency roadside signaling devices are disclosed. In one aspect, a control system for an object placing device of an autonomous vehicle includes a processor, and a computer-readable memory in communication with the processor and having stored thereon computer-executable instructions to cause the processor to: receive a signal comprising instructions to activate the object placing device; and provide instructions to the object placing device to place a plurality of signaling devices in accordance with predetermined criteria.Type: GrantFiled: June 22, 2021Date of Patent: April 2, 2024Assignee: TuSimple, Inc.Inventors: Charles A. Price, Todd B. Skinner, Juexiao Ning, Yishi Liu, Qiwei Li, Raymond Alan Thomas, Alan Camyre, Jim Giglio, Robert Patrick Brown
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Publication number: 20240075062Abstract: The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers.Type: ApplicationFiled: March 3, 2023Publication date: March 7, 2024Inventors: Kole T. ROYBAL, Raymond LIU, Iowis ZHU
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Patent number: 11897932Abstract: The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers.Type: GrantFiled: March 30, 2021Date of Patent: February 13, 2024Assignee: The Regents of the University of CaliforniaInventors: Kole T. Roybal, Raymond Liu, Iowis Zhu
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Publication number: 20230183709Abstract: The present disclosure generally relates to, inter alia, a new class of chimeric Notch receptors containing a fully humanized transcriptional effector, engineered to modulate gene expression and cellular activities in a ligand-dependent manner. The new chimeric Notch receptors surprisingly retain the ability to transduce signals in response to ligand binding despite that the Notch extracellular subunit (NEC), which includes the negative regulatory region (NRR) previously believed to be essential for the functioning of Notch receptors is completely absent. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. Also provided are compositions and methods useful for producing such receptors, nucleic acids encoding same, engineered cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various diseases such as cancers.Type: ApplicationFiled: April 8, 2021Publication date: June 15, 2023Inventors: Kole T. ROYBAL, Raymond LIU
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Publication number: 20230174612Abstract: The present disclosure generally relates to, inter alia, a new class of chimeric Notch receptors containing a synthetic zinc finger transcriptional effector (synZTE) module, engineered to modulate gene expression and cellular activities in a ligand-dependent manner. The new Notch receptors surprisingly retain the ability to transduce signals in response to ligand binding despite that the Notch extracellular subunit (NEC), which includes the negative regulatory region (NRR) previously believed to be essential for the functioning of Notch receptors, is partly or completely deleted. In addition, the synZTE is designed to bind orthogonal DNA target sequences in target organisms which in turn facilitates precise regulation of therapeutic gene expression with minimal off-target activity.Type: ApplicationFiled: March 24, 2021Publication date: June 8, 2023Inventors: Kole T. ROYBAL, Iowis ZHU, Raymond LIU, Ahmad S. KHALIL, Divya ISRANI
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Patent number: 11617766Abstract: The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers.Type: GrantFiled: November 17, 2021Date of Patent: April 4, 2023Assignee: The Regents of the University of CaliforniaInventors: Kole T. Roybal, Raymond Liu, Iowis Zhu
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Publication number: 20220372101Abstract: The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcription in a ligand-dependent manner. The new receptors provide a selectable degree of noise, expression level, and signal to noise ratio. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers.Type: ApplicationFiled: September 23, 2020Publication date: November 24, 2022Inventors: Kole T. ROYBAL, Raymond LIU, Iowis ZHU
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Publication number: 20220356225Abstract: The present disclosure generally relates to, inter alia, a new class of chimeric Notch receptors containing a synthetic zinc finger transcriptional effector (synZTE) module, engineered to modulate gene expression and cellular activities in a ligand-dependent manner. The new Notch receptors surprisingly retain the ability to transduce signals in response to ligand binding despite that the Notch extracellular subunit, which includes the negative regulatory region previously believed to be essential for the functioning of Notch receptors, is partly or completely deleted. In addition, the synZTE is designed to bind orthogonal DNA target sequences in target organisms which in turn facilitates precise regulation of therapeutic gene expression with minimal off-target activity.Type: ApplicationFiled: September 23, 2020Publication date: November 10, 2022Inventors: Kole T. ROYBAL, Iowis ZHU, Raymond LIU, Ahmad S. KHALIL, Divya ISRANI
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Publication number: 20220348628Abstract: The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner Particularly, the new receptors, even though derived from Notch and Robo, do not require the Notch or Robo regulatory regions previously believed to be necessary for the functioning of the receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as diseases (e.g., cancers).Type: ApplicationFiled: September 23, 2020Publication date: November 3, 2022Inventors: Kole T. ROYBAL, Raymond LIU, Iowis ZHU
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Publication number: 20220348677Abstract: The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. In particular, the new receptors contain a heterologous transmembrane domain comprising at least one ?-secretase site. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers.Type: ApplicationFiled: September 23, 2020Publication date: November 3, 2022Inventors: Kole T. ROYBAL, Raymond LIU, Iowis ZHU
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Publication number: 20220340637Abstract: The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate a flexible polypeptide connector region disposed between the extracellular ligand-binding domain (ECD) and the transmembrane domain (TMD) which facilitates optimizing the stiffness/flexibility of the chimeric polypeptides to achieve a desired activity. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as diseases (e.g., cancers).Type: ApplicationFiled: September 23, 2020Publication date: October 27, 2022Inventors: Kole T. ROYBAL, Raymond LIU, Iowis ZHU
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Publication number: 20220133797Abstract: The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers.Type: ApplicationFiled: November 17, 2021Publication date: May 5, 2022Inventors: Kole T. Roybal, Raymond Liu, Iowis Zhu
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Patent number: 11294446Abstract: Examples for setting a system state as one of wakeable through a trigger and non-wakeable, are described. In one example, a value of an enabling time interval is obtained. Thereafter, it is determined if the enabling time interval has elapsed since the computing device has been in a low powered mode. Based on the determining, a system state is set as one of wakeable and non-wakeable through a trigger.Type: GrantFiled: April 20, 2017Date of Patent: April 5, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Poying Chih, Raymond Liu, Shu Ming Kuo
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Patent number: 11202801Abstract: The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers.Type: GrantFiled: March 30, 2021Date of Patent: December 21, 2021Assignee: The Regents of the University of California, UCSFInventors: Kole T. Roybal, Raymond Liu, Iowis Zhu
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Publication number: 20210268024Abstract: The present disclosure generally relates to, inter alia, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. In addition, the new receptors described herein incorporate an extracellular oligomerization domain to promote oligomer formation of the chimeric receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions such as cancers.Type: ApplicationFiled: March 30, 2021Publication date: September 2, 2021Inventors: Kole T. ROYBAL, Raymond Liu, Iowis Zhu
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Publication number: 20210246186Abstract: The present disclosure generally relates to, among other things, a new class of receptors engineered to modulate transcriptional regulation in a ligand-dependent manner. Particularly, the new receptors, even though derived from Notch, do not require the Notch negative regulatory regions previously believed to be essential for the functioning of the receptors. The disclosure also provides compositions and methods useful for producing such receptors, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various health conditions or diseases, such as cancers.Type: ApplicationFiled: March 30, 2021Publication date: August 12, 2021Inventors: Kole T. Roybal, Raymond Liu, Iowis Zhu
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Publication number: 20210089103Abstract: Examples disclosed herein relate to changing power states of a device. Example devices include an input/output port to couple to a component to receive an actuation event. A chipset processor of the device may determine a power state of the device; in response to a determination that the power state is an ultra-low power state, determine a component identification (ID) of the component; fetch a reference ID from non-volatile memory; and compare the determined component ID with the reference ID. The chipset processor of the example device to transmit a signal to change the power state of the device in response to a match between the determined component ID and the reference ID and reception of signals indicative of an actuation event.Type: ApplicationFiled: January 31, 2018Publication date: March 25, 2021Applicant: Hewlett-Packard Development Company, L.P.Inventors: Poying Chih, Tan Lin, Raymond Liu, ChenTai Huang
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Publication number: 20200142468Abstract: Examples for setting a system state as one of wakeable through a trigger and non-wakeable, are described. In one example, a value of an enabling time interval is obtained. Thereafter, it is determined if the enabling time interval has elapsed since the computing device has been in a low powered mode.Type: ApplicationFiled: April 20, 2017Publication date: May 7, 2020Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.Inventors: Poying Chih, Raymond Liu, Shu Ming Kuo
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Patent number: 9915709Abstract: A motor system includes a motor including two Hall sensors configured to output binary values, and a controller configured to control the motor. The two Hall sensors are placed 120 or 60 electrical degrees apart. The controller is operable to monitor output signals of the two Hall sensors and to determine a third Hall sensor output binary value. The controller is operable to fulfill the commanded requirements to operate in a servo system, by controlling commutation of a drive current into the motor, and by keeping track of the motor rotor position based on the third generated signal and the outputs of the two Hall sensors.Type: GrantFiled: December 18, 2015Date of Patent: March 13, 2018Assignee: Woodward, Inc.Inventors: Raymond Liu, Estella Chung