Abstract: The present invention relates to methods of treatment of light chain amyloidosis and other CD38-positive hematological malignancies with anti-CD38 antibodies.

Abstract: An underframe structure for a motor vehicle, the underframe structure comprising a floor (12), and at least two longitudinal side members (14) respectively disposed on each side of the floor (12); the floor (12) is divided into at least one front unit (16) and one rear unit (18) fixed to a transverse heel board (24). The underframe structure also comprises a lateral reinforcement part (26) which comprises at least one elongate body extending from the heel board towards the closest side member, the lateral reinforcement part is fixed on one side to the heel board (24), and on the other side to the front unit (16) of the floor (12) or to a side member (14) in the region of the front unit (16) of the floor.

Abstract: An underframe structure for a motor vehicle, the underframe structure comprising a floor (12), and at least two longitudinal side members (14) respectively disposed on each side of the floor (12); the floor (12) is divided into at least one front unit (16) and one rear unit (18) fixed to a transverse heel board (24). The underframe structure also comprises a lateral reinforcement part (26) which comprises at least one elongate body extending from the heel board towards the closest side member, the lateral reinforcement part is fixed on one side to the heel board (24), and on the other side to the front unit (16) of the floor (12) or to a side member (14) in the region of the front unit (16) of the floor.

Abstract: A mechanical arm includes a first link connectable to a surface, a second link, a third link, a fourth link, and a fifth link that are coupled to one another in series, and an end effector connectable to the fifth link. The end effector is rotatable about an axis of rotation same as an axis of rotation of the fourth link, and rotatable about an axis of rotation orthogonal to the axis of rotation of the fourth link. The first link, the second link, the third link, the fourth link, and the fifth link are collectively structured and configured to rotate such that the end effector is actuatable to a workspace under the surface.

Abstract: A robotic assistant includes a wheeled base, a storage unit including drawers, a foldable arm connected to a top of the storage unit and including an end of arm tooling (EOAT) connected to a distal end of the foldable arm, an elevation mechanism positioned on the wheeled base and used to move the storage unit up and down, and a control system that receives command instructions. In response to the command instructions, the control system is configured to move the wheeled base, open or close the one or more drawers, actuate movement of the foldable arm and the EOAT to pick up and place external objects from/to a determined location, and control the storage unit to move up/down.

Abstract: A wheeled base includes a housing, two driven wheeled mechanisms positioned on a bottom of the housing and on opposite sides of the housing, at least one passive wheel positioned on the bottom of the housing, actuated feet positioned on the bottom of the housing and configured to move up and down, sensors, and a battery pack arranged within the housing. The two driven wheeled mechanisms each includes a damping mechanism, and each damping mechanism includes at least two dampers configured to absorb impact caused by an upward movement of the housing, and absorb impact caused by a downward movement of the housing.

Abstract: A mechanical arm includes a first link connectable to a surface, a second link, a third link, a fourth link, and a fifth link that are coupled to one another in series, and an end effector connectable to the fifth link. The end effector is rotatable about an axis of rotation same as an axis of rotation of the fourth link, and rotatable about an axis of rotation orthogonal to the axis of rotation of the fourth link. The first link, the second link, the third link, the fourth link, and the fifth link are collectively structured and configured to rotate such that the end effector is actuatable to a workspace under the surface.

Abstract: A robotic assistant includes a wheeled base, a storage unit including drawers, a foldable arm connected to a top of the storage unit and including an end of arm tooling (EOAT) connected to a distal end of the foldable arm, an elevation mechanism positioned on the wheeled base and used to move the storage unit up and down, and a control system that receives command instructions. In response to the command instructions, the control system is configured to move the wheeled base, open or close the one or more drawers, actuate movement of the foldable arm and the EOAT to pick up and place external objects from/to a determined location, and control the storage unit to move up/down.

Abstract: A robotic assistant includes a wheeled base, a storage unit including drawers, a foldable arm connected to a top of the storage unit and including an end of arm tooling (EOAT) connected to a distal end of the foldable arm, an elevation mechanism positioned on the wheeled base and used to move the storage unit up and down, and a control system that receives command instructions. In response to the command instructions, the control system is configured to move the wheeled base, open or close the one or more drawers, actuate movement of the foldable arm and the EOAT to pick up and place external objects from/to a determined location, and control the storage unit to move up/down.

Abstract: A modular process for organosolv fractionation of lignocellulosic feedstocks into component parts and further processing of said component parts into one or more of a de-lignified cellulose stream, a sugar stream, small-chain alcohol streams and four structurally distinct classes of lignin derivatives. The modular process comprises a first processing module configured for digesting lignocellulosic feedstocks with an organic solvent thereby producing a cellulosic solids fraction and a liquid fraction, a second processing module configured for recovering small-chain alcohols and optionally a first class of lignin derivatives from the cellulosic solids fraction, a third processing module configured for recovering from the liquid fraction at least one of a second class and a third class of lignin derivatives or mixtures thereof, and waste stream comprising a fourth class of lignin derivatives. The fourth processing module may optionally recover the fourth class of lignin derivatives.

Abstract: The present disclosure provides an organosolv process. The present process comprises treating a lignocellulosic biomass in the presence of a solvent and under certain conditions to separate at least a part of the lignin from the biomass.

Abstract: A modular process for organosolv fractionation of lignocellulosic feedstocks into component parts and further processing of said component parts into one or more of a de-lignified cellulose stream, a sugar stream, small-chain alcohol streams and four structurally distinct classes of lignin derivatives. The modular process comprises a first processing module configured for digesting lignocellulosic feedstocks with an organic solvent thereby producing a cellulosic solids fraction and a liquid fraction, a second processing module configured for recovering small-chain alcohols and optionally a first class of lignin derivatives from the cellulosic solids fraction, a third processing module configured for recovering from the liquid fraction at least one of a second class and a third class of lignin derivatives or mixtures thereof, and waste stream comprising a fourth class of lignin derivatives. The fourth processing module may optionally recover the fourth class of lignin derivatives.

Abstract: A modular process for organosolv fractionation of lignocellulosic feedstocks into component parts and further processing of said component parts into one or more of a de-lignified cellulose stream, a sugar stream, small-chain alcohol streams and four structurally distinct classes of lignin derivatives. The modular process comprises a first processing module configured for digesting lignocellulosic feedstocks with an organic solvent thereby producing a cellulosic solids fraction and a liquid fraction, a second processing module configured for recovering small-chain alcohols and optionally a first class of lignin derivatives from the cellulosic solids fraction, a third processing module configured for recovering from the liquid fraction at least one of a second class and a third class of lignin derivatives or mixtures thereof, and waste stream comprising a fourth class of lignin derivatives. The fourth processing module may optionally recover the fourth class of lignin derivatives.

Abstract: A modular process for organosolv fractionation of lignocellulosic feedstocks into component parts and further processing of said component parts into one or more of a de-lignified cellulose stream, a sugar stream, small-chain alcohol streams and four structurally distinct classes of lignin derivatives. The modular process comprises a first processing module configured for digesting lignocellulosic feedstocks with an organic solvent thereby producing a cellulosic solids fraction and a liquid fraction, a second processing module configured for recovering small-chain alcohols and optionally a first class of lignin derivatives from the cellulosic solids fraction, a third processing module configured for recovering from the liquid fraction at least one of a second class and a third class of lignin derivatives or mixtures thereof, and waste stream comprising a fourth class of lignin derivatives. The fourth processing module may optionally recover the fourth class of lignin derivatives.

Abstract: An electronic switch (29) for automatically connecting a subscriber telephone instrument (31a, 31b, 31c, or 31d) to either of two telephone signal paths (27 or 28) is disclosed. Outbound calls are selectively routed to one or the other of the two telephone signal paths, based on the nature of the initial digits generated by the subscriber. Local calls are sent to a local exchange carrier (23a) and toll calls are sent to an inter-exchange carrier (25) via a transmission medium that may also carry other signals, such as cable television or utility energy management signals. In the event the normal path is out of service, outbound signals are sent via the other path. Inbound signals from either path are automatically routed to the subscriber. Signal routing is completely transparent to the subscriber.

Abstract: A switched access emergency (i.e., 9-1-1) telephone system that uses the trunks of a public telephone network (PTN) with the same reliability as a 9-1-1 telephone system that uses a dedicated line is disclosed. The switched access system includes a trunk dial unit (TDU) connected to the central office receiving 9-1-1 calls and a call access unit (CAU) connected to the 9-1-1 public service answering point (PSAP) that the caller desires to contact. 9-1-1 calls to the caller's central office are directed to the TDU, which calls the PSAP via the PTN and the CAU. The TDU captures the automatic number identification (ANI) information associated with the calling telephone and sends the ANI information to the PSAP when requested to do so. During idle periods, the TDU regularly communicates with the CAU via the PTN to determine the availability of the CAU and, thus, the PSAP. The TDU can be programmed to contact one or more secondary PSAPs if a primary PSAP is unavailable.

Abstract: An offset adapter connector for use with a plug-in device, such as the line (L) relay of an originating register, that allows connections to be made to the terminals of the device and to the terminals of the socket into which the device is normally plugged is disclosed. The offset adapter connector includes an elongate housing having mounted therein, in axially offset positions, a plug and a socket. The connector plug fits into the socket into which the plug-in device is normally plugged and the plug-in device fits into the connector socket. Due to the side-by-side position of the connector plug andsocket, the plug-in device is offset from its normal position. While offset, the plug-in device retains its normal orientation, (e.g., vertical). As necessary, the connector plug and socket are wired together and to a cable suitable for making connections to related electronic circuitry.

Abstract: A solid state pulsing circuit and an adapter connector for pulsing the counting and register advance terminals of the L-(line) relay of an originating register in accordance with the digit nature of received DTMF signals is disclosed. The pulsing circuit includes a pair of solid state switches adapted to be alternatively actuated and the adapter connector connects the pulsing circuit to the counting and register advance terminals of the line relay without affecting the normal operation of the relay. Complementary MAKE and BREAK signals derived from the serial pulse output of a DTMF receiver operate the solid state pulsing circuit such that the pulsing circuit alternately pulses (opens and grounds) the counting and register advance terminals of the line relay in accordance with the production of pulses by the DTMF receiver. Other relay terminals (i.e.

Abstract: A circuit for preventing the automatic operation of the time-out portion of a tone-to-pulse converter until after the first DTMF digit is dialed is disclosed. When a calling party goes OFF HOOK, the forward loop current flowing in the tip and ring in leads is sensed. The sensed current creates a binary zero signal that sets a latch circuit. The latch circuit inhibits the automatic operation of the time-out portion of the tone-to-pulse converter until the latch circuit is reset. The latch circuit is normally reset by the first output of the tone-to-pulse converter adapted to create a rotary dial-type pulse. Alternatively, going ON HOOK without creating a DTMF digit resets the latch circuit, as does the occurrence of a rotary dial pulse on the tip and ring in leads.