Abstract: The present invention relates to the field of lipid nanoparticles (LNP); more specifically comprising an ionizable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in comprising less than about 1 mol % of a C14-PEG2000 lipid; as well as particular percentages of the other lipids. The present invention provides use of the LNP's for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.

Abstract: The present invention relates to an adhesive drug carrier comprising an injectable hydrogel comprising at least one medication, wherein the hydrogel comprises a (i) a protein-based polymer functionalized with a functionalization agent that is able to form guest-host interactions with oxidized P-cyclodextrin, cross-linked with (ii) an oxidized P-cyclodextrin (o?-CD) as matrix and the at least one medication (iii), and wherein the hydrogel further comprises (iv) a protein-based polymer bearing quinone and/or catechol groups. The invention further relates to a method for its preparation and a method for treatment.

Abstract: The invention relates to the use of a composition comprising a corticosteroid encapsulated in a vesicle for the manufacture of a medicament for treating cancer, such as the use of a composition comprising a corticosteroid and liposomes, the liposomes comprising a non-charged vesicle-forming lipid, and optionally an amphipathic vesicle-forming lipid and/or a negatively charged vesicle-forming lipid. The invention further relates to a new pharmaceutical composition suitable for treating cancer, and especially solid primary and secondary tumors.

Abstract: The present invention relates to compositions comprising non-steroidal anti-inflammatory compounds, and especially to the use of such compositions in the treatment of cancer or in the inhibition of cancer growth. More specifically, the invention relates to a method for targeting an anti-inflammatory compound to tumor tissue.

Abstract: The present invention relates to liposomal compositions comprising polyphenol in the interior of a colloidal carrier, and especially to the use of such compositions in the treatment of cancer or in the inhibition of cancer growth and in the treatment of inflammatory and autoimmune conditions. More specifically, the invention relates to a method for targeting a polyphenol to tumor tissue, or to sites in the body requiring anti-inflammatory activity or activity against autoimmune conditions. Furthermore, the present invention describes a method of post-loading a polyphenol derivate such as caffeic acid into a liposome.

Abstract: A rules system for creating rules to an expert system is provided, the rules system providing a user-friendly, guided process for creating such rules.

Abstract: A rules system for creating rules to an expert system is provided, the rules system providing a user-friendly, guided process for creating such rules.

Abstract: The invention relates to a system for broadcasting media comprising at least one client application (4) and a separate broadcasting engine (9). The planning is carried out in the client application in the form of drop-down lists comprising several media objects referring to media such as audio, video, fireworks, laser etc. The broadcasting engine receives said lists, collects and then places them in a principal list depending on provisions given in the client application. The drop-down lists may be modified in the broadcasting engine from the client application. The broadcasting engine may open several sessions, each session being related to a given media type.

Abstract: The invention relates to the means provided in a peristaltic pump to regulate the radial distance between a crushing roller and the axle of rotation of the rotor.The rotor comprises at least one reference face parallel to its axle of rotation, the regulating element being a support of the axle of rotation of the roller provided with a surface which is held in contact with the face of the rotor, whereas a plurality of orifices are provided in the rotor and one orifice is provided in the support and is designed to be placed over one of the orifices of said plurality by moving the support along the said face and surface and to receive a connecting member traversing them.The invention finds an application in peristaltic pumps.

Abstract: Apparatus and method of circulating a gas through coils of very long tubing during a heat treatment, wherein the coils of tubing are placed on hollow frames through which the clearing gas passes. The frames are fitted with nozzles to which at least one end of each coil can be connected. The invention can be applied to continuous annealing of coils of small-diameter copper tubing with a view to removing the last traces of drawing lubricant.