Abstract: A method for altering the spring constant (k) of a torsion spring for a roller blind, the method including (i) locating a dampener at a predetermined length along a longitudinal axis of the torsion spring, and (ii) tightening an end of the torsion spring against the dampener to increase the spring constant. Further disclosed is a roller blind system having a cylinder, a fabric attached to the cylinder for winding and unwinding from said cylinder, a torsion spring and a damper moveable along the longitudinal axis of the spring.

Abstract: A method for altering the spring constant (k) of a torsion spring for a roller blind, the method including (i) locating a dampener at a predetermined length along a longitudinal axis of the torsion spring, and (ii) tightening an end of the torsion spring against the dampener to increase the spring constant. Further disclosed is a roller blind system having a cylinder, a fabric attached to the cylinder for winding and unwinding from said cylinder, a torsion spring and a damper moveable along the longitudinal axis of the spring.

Abstract: The invention relates to coupling at least two window coverings and, provides apparatus for coupling a first and second window covering in substantially coaxial alignment comprising the combination of a bracket and a bearing insert, where: the bracket comprises at least one first portion adapted for fixing the bracket to a structure and a second portion comprising a combination of one or more generally C-shaped apertures; the bearing insert comprises a generally annular assembly with first and second side portions secured together by a hub portion, the hub portion having an outer surface configured as a truncated circle, wherein the truncated circle configuration of the hub portion is adapted to allow passage of the bearing insert into the C-shaped aperture and prevent passage out of the C-shaped aperture upon rotation of the bearing insert in the C-shaped aperture.

Abstract: The invention relates to coupling at least two window coverings and, provides apparatus for coupling a first and second window covering in substantially coaxial alignment comprising the combination of a bracket and a bearing insert, where: the bracket comprises at least one first portion adapted for fixing the bracket to a structure and a second portion comprising a combination of one or more generally C-shaped apertures; the bearing insert comprises a generally annular assembly with first and second side portions secured together by a hub portion, the hub portion having an outer surface configured as a truncated circle, wherein the truncated circle configuration of the hub portion is adapted to allow passage of the bearing insert into the C-shaped aperture and pre vent passage out of the C-shaped aperture upon rotation of the bearing insert in the C-shaped aperture

Abstract: The present invention relates to the identification of a PEST motif in Suppressor of Cytokine Signalling (SOCS) proteins, the deletion/inactivation of which has been found to increase the stability of the protein whilst maintaining at least one biological activity of the protein. Such SOCS proteins with deleted/inactivated PEST motifs can be used in gene and protein therapy procedures to provide a more stable SOCS protein when compared to the native protein. The present invention also relates to the characterization of the structure of SOCS proteins, and methods of using this structural information to identify compounds which modulate the activity of SOCS.

Abstract: This invention relates to methods and compositions for the treatment of conditions associated with abnormal activity or secretion of the hormone gastrin. In particular the invention relates to the treatment of conditions associated with non-amidated gastrin. In one aspect there is provided a method of treatment or prophylaxis of a condition associated with elevated levels of non-amidated gastrin, comprising the step of administering to a mammal in need of such treatment an effective amount of a compound which has the ability to inhibit the binding of ferric ions to any one or more of glycine-extended gastrin17 or progastrin or progastrin-derived peptides, but which does not inhibit the activity of amidated gastrin, thereby to inhibit the activity of non-amidated gastrins.

Abstract: Various divalent ligands based on khellinone derivatives are described. These derivatives can be useful in the modulation of potassium channel activity in cells, including among others Kv1.3 channels found in T-cells. The compounds may also be useful in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis.

Abstract: Various chalcone derivatives of the general formula (I) are described and the variables, A, B, m and R1 to R10 are as defined in the specification. These derivatives can be useful in the modulation of potassium channel activity in cells and may be useful in the treatment or prevention of autoimmune and inflammatory diseases.