Patents by Inventor Raymond P. Warrell

Raymond P. Warrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Taxane compounds, compositions and methods
    Patent number: 9434740
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: September 6, 2016
    Assignee: ODONATE THERAPEUTICS, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Methods for reducing uric acid levels using barbiturate derivatives
    Patent number: 9428466
    Abstract: Methods for reducing uric acid levels in blood or serum of a subject employing metabolites of merbarone as active agents. Methods for treating or preventing disorders of uric acid metabolism are also provided. The metabolites can be formulated as pharmaceutical compositions comprising the metabolites and a pharmaceutically acceptable carrier for use in these methods.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: August 30, 2016
    Inventor: Raymond P. Warrell, Jr.
  • Taxane compounds, compositions and methods
    Patent number: 9284327
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: March 15, 2016
    Assignee: GFV, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Gallium Complexes, Pharmaceutical Compositions and Methods of Use
    Publication number: 20150175631
    Abstract: The present invention provides complexes of gallium with a ligand, methods of making the complexes, methods of using the complexes and pharmaceutical gallium compositions comprising the complexes, in particular those compositions suitable for therapeutic oral administration.
    Type: Application
    Filed: January 26, 2015
    Publication date: June 25, 2015
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Methods for Reducing Uric Acid Levels Using Barbiturate Derivatives
    Publication number: 20150133477
    Abstract: Methods for reducing uric acid levels in blood or serum of a subject employing metabolites of merbarone as active agents. Methods for treating or preventing disorders of uric acid metabolism are also provided. The metabolites can be formulated as pharmaceutical compositions comprising the metabolites and a pharmaceutically acceptable carrier for use in these methods.
    Type: Application
    Filed: November 13, 2013
    Publication date: May 14, 2015
    Inventor: Raymond P. Warrell, JR.
  • Taxane Compounds, Compositions and Methods
    Publication number: 20150080578
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: July 8, 2014
    Publication date: March 19, 2015
    Inventors: John K. Thottathil, Raymond P. Warrell
  • TAXANE COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20140249186
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 4, 2014
    Applicant: GFV, LLC
    Inventors: JOHN K. THOTTATHIL, RAYMOND P. WARRELL
  • Taxane compounds, compositions and methods
    Patent number: 8785669
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: July 22, 2014
    Assignee: GFV, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell, Jr.
  • Taxane compounds, compositions and methods
    Patent number: 8697892
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: April 15, 2014
    Assignee: GFV, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Gallium Complexes, Pharmaceutical Compositions And Methods Of Use
    Publication number: 20120245135
    Abstract: The present invention provides complexes of gallium with a ligand, methods of making the complexes, methods of using the complexes and pharmaceutical gallium compositions comprising the complexes, in particular those compositions suitable for therapeutic oral administration.
    Type: Application
    Filed: March 22, 2012
    Publication date: September 27, 2012
    Applicant: Genta Incorporated
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
    Patent number: 8273379
    Abstract: The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: September 25, 2012
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Raymond P. Warrell, Jr., Pier Paolo Pandolfi, Janice L. Gabrilove
  • Taxane Compounds, Compositions And Methods
    Publication number: 20120220634
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 30, 2012
    Applicant: Genta Incorporated
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Taxane Compounds, Compositions And Methods
    Publication number: 20120004429
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 5, 2012
    Applicant: Genta Incorporated
    Inventors: John K. Thottathil, Raymond P. Warrell, JR.
  • PROCESS FOR PRODUCING ARSENIC TRIOXIDE FORMULATIONS AND METHODS FOR TREATING CANCER USING ARSENIC TRIOXIDE OR MELARSOPROL
    Publication number: 20110091573
    Abstract: The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
    Type: Application
    Filed: December 21, 2010
    Publication date: April 21, 2011
    Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Raymond P. Warrell, JR., Pier Paolo Pandolfi, Janice L. Gabrilove
  • Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
    Patent number: 7879364
    Abstract: The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: February 1, 2011
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Raymond P. Warrell, Jr., Pier Paolo Pandolfi, Janice L. Gabrilove
  • Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
    Patent number: 7855183
    Abstract: The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: December 21, 2010
    Assignee: Genta Incorporated
    Inventor: Raymond P. Warrell, Jr.
  • Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
    Patent number: 7795232
    Abstract: The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: September 14, 2010
    Assignee: Genta Incorporated
    Inventors: Raymond P. Warrell, Robert E. Klem, Howard Fingert
  • Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
    Publication number: 20100216867
    Abstract: The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.
    Type: Application
    Filed: April 2, 2010
    Publication date: August 26, 2010
    Applicant: Genta Incorporated
    Inventors: Raymond P. Warrell, JR., Howard Fingert, Robert Klem
  • Pharmaceutical Gallium Compositions and Methods
    Publication number: 20090275655
    Abstract: The present invention provides novel pharmaceutical gallium compositions, as well as methods for their preparation and methods for treating conditions and diseases such as cancer, hypercalcemia, osteoporosis, osteopenia, Paget's disease, and infections.
    Type: Application
    Filed: April 28, 2009
    Publication date: November 5, 2009
    Applicant: Genta Incorporated
    Inventors: Raymond P. Warrell, JR., Bob D. Brown
  • Tri(alkylcarboxylato)gallium (III) products and pharmaceutical compositions containing them
    Patent number: 7119217
    Abstract: Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: October 10, 2006
    Assignee: Genta Incorporated
    Inventors: Jack B. Jiang, Raymond P. Warrell, Jr., Kollengode K. Ramaswamy, Robert E. Klem