Abstract: Described herein are positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) systems and methods of use. In one example, a PET-EPRI system includes a PET-EPR insert, a PET scanner including one or more solid-state photodetectors, and a subject module that can house a subject for scanning. The PET-EPR insert includes an EPR resonator that can nest inside the PET scanner. The EPR resonator includes a resonator that can receive the subject module, a shield encircling the resonator and one or more rapid scan coils (RS-coils) positioned around the shield. The shield can prevent electrical coupling between the RS-coils and the resonator while being transparent to annihilation photons and magnetic field scans.

Abstract: Described herein are PET-EPRI systems and methods of use.

Abstract: Disclosed are various embodiments of an auto-injector device that automatically and dynamically adjusts the depth that a needle will penetrate into a target area of the body. In one embodiment, the auto-injector device includes the needle being moveably disposed within a needle housing. The auto-injector device further includes a needle depth estimator having a needle depth limiter that extends into an inner portion of the needle housing and is designed to engage with a needle stop of the needle and restrict downward movement of the needle. The needle depth estimator can automatically adjust a position of the needle depth limiter within the needle housing according to movement of a compression mechanism surrounding a lower portion of the needle housing.

Abstract: Disclosed are various embodiments of an auto-injector device that automatically and dynamically adjusts the depth that a needle will penetrate into a target area of the body. In one embodiment, the auto-injector device includes the needle being moveably disposed within a needle housing. The auto-injector device further includes a needle depth estimator having a needle depth limiter that extends into an inner portion of the needle housing and is designed to engage with a needle stop of the needle and restrict downward movement of the needle. The needle depth estimator can automatically adjust a position of the needle depth limiter within the needle housing according to movement of a compression mechanism surrounding a lower portion of the needle housing.

Abstract: An intraoperative probe system for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical is described. In one embodiment, the probe system of the present invention is a probe having an ion-implanted silicon charged-particle detector for generating an electrical signal in response to received beta particles. In such an embodiment, a preamplifier may be located in close proximity to the detector filters and amplifies the electrical signal. Furthermore, a wire may be used to couple the probe to a processing unit for amplifying and filtering the electrical signal, and a counter may be utilized to analyze the resulting electrical signal to determine the number of beta particles being received by the detector. Alternatively, the wire can be replaced with an infrared or radio transmitter and receiver for wireless operation of the probe.

Abstract: A modular radiation detecting probe system includes a probe body having a handle portion and a distal portion to which an extension member is attached. The free end of the extension member is adapted to matingly attach and detach, one at a time, with various probe tips. An electronic signal acquisition system is disposed within the probe body and is coupled to receive a signal output from an attached probe tip. The acquisition system signal process the signal to discriminate between noise and a radiation signal detected by the probe tip. The probe body may include visual and/or audible devices to signal when the probe tip is adjacent a radiated area. The probe body may include a transmitted to transmit acquired signal data to an external signal processing unit, which may be a computer.

Abstract: An intraoperative probe system for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical is described. In one embodiment, the probe system of the present invention is a probe having an ion-implanted silicon charged-particle detector for generating an electrical signal in response to received beta particles. In such an embodiment, a preamplifier may be located in close proximity to the detector filters and amplifies the electrical signal. Furthermore, a wire may be used to couple the probe to a processing unit for amplifying and filtering the electrical signal, and a counter may be utilized to analyze the resulting electrical signal to determine the number of beta particles being received by the detector. Alternatively, the wire can be replaced with an infrared or radio transmitter and receiver for wireless operation of the probe.

Abstract: A medical method and apparatus for the localization and biospy of lesions in a patient body part. A radiopharmaceutical is administered to the patient followed by placement of the body part within a scanner for obtaining emission data. The emission data is converted into Cartesian coordinates which are used to guide a sampling instrument for the biopsy of said lesion.

Abstract: An intraoperative system made be used for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical. The system has ion-implanted silicon charged-particle detectors for generating signals in response to received beta particles. A preamplifier may be located in proximity to the detector filters and amplifies the signal. Also, a wire may be used to couple the probe to a processing unit for amplifying and filtering the signal.

Abstract: An intraoperative probe system for preferentially detecting beta radiation over gamma radiation emitted from a radiopharmaceutical. In one embodiment, the probe system is a probe having an ion-implanted silicon charged-particle detector for generating an electrical signal in response to received beta particles. In such an embodiment, a preamplifier may be located in close proximity to the detector filters and amplifies the electrical signal. Furthermore, a wire may be used to couple the probe to a processing unit for amplifying and filtering the electrical signal, and a counter may be utilized to analyze the resulting electrical signal to determine the number of beta particles being received by the detector. Alternatively, the wire can be replaced with an infrared or radio transmitter and receiver for wireless operation of the probe.