Patents by Inventor Raymond T. Testa

Raymond T. Testa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibiotic LL-C19004
    Patent number: 4699790
    Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: October 13, 1987
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Donald B. Borders, May D. Lee, William M. Maiese, Raymond T. Testa, David P. Labeda
  • Antibiotic agents from S. coeruleorubidus, rubidus
    Patent number: 4677071
    Abstract: This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
    Type: Grant
    Filed: August 6, 1984
    Date of Patent: June 30, 1987
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, John H. Martin, Donald B. Borders, Raymond C. Yao, Raymond T. Testa
  • Biologically pure culture of Streptoverticillium stramineum sp. nov.
    Patent number: 4650765
    Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
    Type: Grant
    Filed: July 30, 1985
    Date of Patent: March 17, 1987
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Amedeo A. Fantini, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
  • Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega..sub.1, LL-D49194.omega..sub.2, and LL-D49194.omega..sub.3
    Patent number: 4626503
    Abstract: Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: December 2, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Amedeo A. Fantini, David P. Labeda, William M. Maiese, Raymond T. Testa, Donald B. Borders
  • Biologically pure culture of Streptomyces majorciensis Labeda
    Patent number: 4608343
    Abstract: This disclosure describes four new antibacterial agents designated LL-C08078.alpha..sub.1, LL-C08078.alpha..sub.2, LL-C08078.alpha..sub.3 and LL-C08078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: August 26, 1986
    Assignee: American Cyanamid Company
    Inventors: David P. Labeda, Joseph J. Goodman, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
  • Preparation of antibiotic LL-D05139.beta. from cultures of Glycomyces harbinensis, gen. nov., sp. nov.
    Patent number: 4568646
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139.beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: January 24, 1985
    Date of Patent: February 4, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa
  • Antibiotic LL-BO1208.alpha. and LL-BO1208.beta., process of preparation, pharmaceutical composition and method of use
    Patent number: 4552867
    Abstract: This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
    Type: Grant
    Filed: July 5, 1983
    Date of Patent: November 12, 1985
    Assignee: American Cyanamid Company
    Inventors: John H. E. J. Martin, Jane P. Kirby, Donald B. Borders, Amedeo A. Fantini, Raymond T. Testa
  • Antibiotic LL-D42067.alpha.
    Patent number: 4551533
    Abstract: Antibiotic LL-D42067.alpha. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: November 5, 1985
    Assignee: American Cyanamid Company
    Inventors: Taikwang M. Lee, Donald B. Borders, Joseph J. Goodman, Raymond T. Testa, William M. Maiese, David P. Labeda
  • Antibacterial antibiotics LL-CO8078.alpha..sub.1, .alpha..sub.2, .alpha..sub.3 and .beta.
    Patent number: 4534970
    Abstract: This disclosure describes four new antibacterial agents designated LL-CO8078.alpha..sub.1, LL-CO8078.alpha..sub.2, LL-CO8078.alpha..sub.3 and LL-CO8078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: August 13, 1985
    Assignee: American Cyanamid Company
    Inventors: David P. Labeda, Joseph J. Goodman, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
  • Antibiotic LL-D05139 .beta.
    Patent number: 4503044
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139 .beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: March 5, 1985
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa
  • Antibiotic agents from S. coeruleorubidus, rubidus
    Patent number: 4499075
    Abstract: This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
    Type: Grant
    Filed: March 25, 1982
    Date of Patent: February 12, 1985
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, John H. Martin, Donald B. Borders, Raymond C. Yao, Raymond T. Testa
  • Process for producing the antibiotic nosiheptide
    Patent number: 4384043
    Abstract: This disclosure describes a novel process for the production of the known antibiotic nosiheptide using a new strain of Streptomyces glaucogriseus and mutants thereof.
    Type: Grant
    Filed: September 2, 1981
    Date of Patent: May 17, 1983
    Assignee: American Cyanamid Company
    Inventors: John H. E. J. Martin, David P. Labeda, Joseph D. Korshalla, Donald B. Borders, Raymond T. Testa
  • Antibiotic W-10 complex, antibiotic 20561 and antibiotic 20562 as antifungal agents
    Patent number: 4232006
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotic W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: November 4, 1980
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Process for the preparation of antibiotic W-10 complex and for the isolation of Antibiotic 20561 and Antibiotic 20562 therefrom
    Patent number: 4230799
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotoc W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: October 28, 1980
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Process for the preparation of antibiotic W-10 complex and for the isolation of antibiotic 20561 and antibiotic 20562 therefrom
    Patent number: 4137224
    Abstract: A novel antibiotic complex exhibiting antifungal activity is produced by fermenting a novel species of bacteria from the genus Aeromonas, the bacterium being herein designated Aeromonas sp. W-10. The antibiotic complex is comprised of at least three and possibly as many as six components and has been designated Antibiotic W-10 Complex. Two members of the complex have been isolated in substantially pure form and are designated Antibiotic 20561 and Antibiotic 20562, the antibiotics exhibiting substantial antifungal activity.
    Type: Grant
    Filed: February 9, 1977
    Date of Patent: January 30, 1979
    Assignee: Schering Corporation
    Inventors: David Taplin, Marvin J. Weinstein, Raymond T. Testa, Joseph A. Marquez, Mahesh G. Patel
  • Antibiotic complex from micromonospora arborensis
    Patent number: 4078056
    Abstract: Micromonospora arborensis produces a plurality of antibiotics named herein antibiotic 68-1147 complex, when cultivated under controlled aerobic conditions. Two of the antibiotics, antibiotic 68-1147 I and antibiotic 68-1147 II are described and shown to be effective antibacterial agents, especially against gram positive bacteria.
    Type: Grant
    Filed: February 2, 1976
    Date of Patent: March 7, 1978
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Joseph A. Marquez, Raymond T. Testa
  • Antibiotic G-418 and the production thereof
    Patent number: 3997403
    Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
    Type: Grant
    Filed: October 10, 1975
    Date of Patent: December 14, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Raymond T. Testa, Joseph A. Marquez
  • Antibiotic G-418 and the production thereof
    Patent number: 3959254
    Abstract: A novel actinomycete herein designated Micromonospora rhodorangea elaborates a product having substantial antibacterial activity, said activity being due primarily to a novel antibiotic herein designated Antibiotic G-418. The disclosure sets forth methods for producing, isolating and using said antibiotic.
    Type: Grant
    Filed: November 8, 1973
    Date of Patent: May 25, 1976
    Assignee: Schering Corporation
    Inventors: Marvin J. Weinstein, Gerald H. Wagman, Raymond T. Testa, Joseph A. Marquez