Patents by Inventor Raymond Taeyong Chung

Raymond Taeyong Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of replicative hepatitis C virus
    Patent number: 6828139
    Abstract: A nucleic acid having a first nucleotide sequence encoding an infectious hepatitis C virus, a second nucleotide sequence encoding a ribozyme, and an inducible promoter operably linked to the first and second nucleotide sequences, the ribozyme being configured to remove a 3′ sequence unnecessary for replication of the infectious hepatitis C virus from a transcript initiated by the inducible, is described. A cell containing the nucleic acid and methods of using the cell are also described.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: December 7, 2004
    Assignee: The General Hospital Corporation
    Inventors: Emmett Vance Schmidt, Raymond Taeyong Chung
  • Screening assay for hepatitis C virus antiviral agents
    Publication number: 20030148267
    Abstract: The invention includes methods of identifying compounds that increase the mutation rate of hepatitis C virus. The invention can be used to screen libraries of test compounds, including both nucleoside analogs and non-nucleoside analogs. The methods include: 1) contacting a test cell with a candidate compound, wherein the test cell contains a nucleic acid molecule comprising an infectious hepatitis C viral genome, a ribozyme, and an inducible promoter operably linked to the first and second nucleotide sequences, the ribozyme being configured to remove a 3′ sequence unnecessary for replication of the infectious hepatitis C viral genome from a transcript initiated by the inducible promote; and 2) the detection of an increase in hepatitis C virus quasispecies produced by the cell in the presence of the candidate compound. Detection of an increase in quasispecies can be accomplished by, e.g., sequencing HCV nucleic acid molecules isolated from the test cell.
    Type: Application
    Filed: November 8, 2002
    Publication date: August 7, 2003
    Inventors: Emmett Vance Schmidt, Raymond Taeyong Chung
  • Production of replicative hepatitis C virus
    Publication number: 20030013085
    Abstract: A nucleic acid having a first nucleotide sequence encoding an infectious hepatitis C virus, a second nucleotide sequence encoding a ribozyme, and an inducible promoter operably linked to the first and second nucleotide sequences, the ribozyme being configured to remove a 3′ sequence unnecessary for replication of the infectious hepatitis C virus from a transcript initiated by the inducible, is described. A cell containing the nucleic acid and methods of using the cell are also described.
    Type: Application
    Filed: July 26, 2002
    Publication date: January 16, 2003
    Applicant: The General Hospital Corporation, a corporation
    Inventors: Emmett Vance Schmidt, Raymond Taeyong Chung
  • Production of replicative hepatitis C virus
    Patent number: 6447994
    Abstract: A nucleic acid having a first nucleotide sequence encoding an infectious hepatitis C virus, a second nucleotide sequence encoding a ribozyme, and an inducible promoter operably linked to the first and second nucleotide sequences, the ribozyme being configured to remove a 3′ sequence unnecessary for replication of the infectious hepatitis C virus from a transcript initiated by the inducible, is described. A cell containing the nucleic acid and methods of using the cell are also described.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: September 10, 2002
    Assignee: The General Hospital Corporation
    Inventors: Emmett Vance Schmidt, Raymond Taeyong Chung