Abstract: A paper-based packaging article includes outer and intermediate paper plies and an inner polymer film ply. A first adhesive layer is disposed between the inner and intermediate paper plies for gluing the inner polymer film ply to the intermediate paper ply. A second adhesive layer is disposed between the intermediate and outer paper plies for gluing the intermediate paper ply to the outer paper ply. The first and second adhesive layers overlap and are coaligned. The outer and intermediate paper plies and the inner polymer film ply are adjoined to form a multiwall structure, wherein the first adhesive layer and the second adhesive layer are coaligned with each other on the multiwall structure. The first adhesive layer comprises a first plurality of adhesive spots and the second adhesive layer comprises a second plurality of adhesive spots, wherein the adhesive spots of the first plurality of adhesive spots do not overlap with the adhesive spots of the second plurality of adhesive spots.

Abstract: A tooling assembly suitable for use in infiltrating a fibrous preform comprises an outer tooling fixture and an inner tooling fixture. The outer tooling fixture comprises a first portion removably attached to a second portion, and a first pair of oppositely disposed windows defined by the first portion and the second portion. Each of the first portion and the second portion comprise a base with a recess. The inner tooling fixture comprises a body defined by at least one portion, the body configured to at least partially surround the fibrous preform, a plurality of holes extending through a thickness of the at least one portion, each hole of the plurality of holes having a length (L) and a diameter (D), and a first neck region engageable with a recess of the first portion or the second portion.

Abstract: A representative reconfigurable processing circuit and a reconfigurable arithmetic circuit are disclosed, each of which may include input reordering queues; a multiplier shifter and combiner network coupled to the input reordering queues; an accumulator circuit; and a control logic circuit, along with a processor and various interconnection networks. A representative reconfigurable arithmetic circuit has a plurality of operating modes, such as floating point and integer arithmetic modes, logical manipulation modes, Boolean logic, shift, rotate, conditional operations, and format conversion, and is configurable for a wide variety of multiplication modes. Dedicated routing connecting multiplier adder trees allows multiple reconfigurable arithmetic circuits to be reconfigurably combined, in pair or quad configurations, for larger adders, complex multiplies and general sum of products use, for example.

Abstract: Apparatuses, systems, and techniques for supporting fairness of multiple context sharing cryptographic hardware. An accelerator circuit includes a copy engine (CE) with AES-GCM hardware configured to perform both encryption and authentication of data transfers for multiple applications or multiple data streams in a single application or belonging to a single user. The CE splits a data transfer of a specified size into a set of partial transfers. The CE sequentially executes the set of partial transfers using a context for a period of time (e.g., a timeslice) for an application. The CE stores in a secure memory for the application one or more data for encryption or decryption (e.g., a hash key, a block counter, etc.) computed from a last partial transfer. The one or more data for encryption or decryption are retrieved and used when data transfers for the application is resumed by the CE.

Abstract: Provided herein are biparatopic antigen-binding constructs that specifically bind HER2. The biparatopic antigen-binding constructs comprise one antigen-binding moiety that binds to ECD2 of HER2, a second antigen-binding moiety that binds to ECD4 of HER2, and an Fc. At least one of the antigen-binding moieties is an scFv. The biparatopic antigen-binding constructs can be used in the treatment of cancer.

Abstract: A steerable overtube assembly for a robotic surgical system can include a steerable shaft having one or more instrument channel and a control hub configured to mount to the steerable shaft. The assembly can also include a manual actuator extending from the control hub and configured to allow the steerable shaft to be manually steered by a user's hand, and a robotic actuator housed by and/or extending from the control hub configured to connect to a robotic driver to allow robotic steering of the steerable shaft.

Abstract: A method of initiating a KPI backfill operation for a cellular network based on detecting a network data anomaly, where the method includes receiving, by an anomaly detection and backfill engine (ADBE) executed by a computing device, a data quality metric that is based on a KPI of the cellular network; detecting, by the ADBE, the network data anomaly based on the data quality metric being more than a threshold amount different than a predicted value for the data quality metric, where the network data anomaly indicates that at least a portion of a data stream from which the KPI is calculated was unavailable for a previous iteration of the KPI; and providing, by the ADBE and based on detecting the network data anomaly, a backfill command to a backfill processing pipeline to perform the backfill operation by reaggregating the KPI when the portion of the data stream becomes available.

Abstract: The present invention is directed to compounds, compositions and methods for treating or preventing Zika virus. The compounds include pyrimidine and purine nucleosides and prodrugs thereof, including certain N4-hydroxycytidine nucleoside derivatives, sulfasalazine, and various entry inhibitors.

Abstract: Some implementations are directed to adapting a client application on a feature phone based on experiment parameters. Some of those implementations are directed to adapting an assistant client application, where the assistant client application interacts with remote assistant component(s) to provide automated assistant functionalities via the assistant client application of the feature phone. Some implementations are additionally or alternatively directed to determining whether an invocation, of an assistant client application on a feature phone, is a request for transcription of voice data received in conjunction with the invocation, or is instead a request for an assistant response that is responsive to the transcription of the voice data (e.g., includes assistant content that is based on and in addition to the transcription, and that optionally lacks the transcription itself).

Abstract: A group definition is received via a network interface. Communications are transmitted to destinations, the communications comprising an invitation to associate with the a content sharing group. Authentication data associated with users that accept the invention is encrypted. The accepting users are associated with the content sharing group. A content gallery definition is received. A communication is received that the content gallery is to be shared with the content sharing group. The content gallery is caused to be instantiated on devices of users associated with the group. A content request for the content sharing group is received and the content request is transmitted accordingly to users associated with the group. A content item is received in response the request and the content item is transmitted to user devices associated with the group and enabled to appear in instantiations of the content gallery on the user devices.

Abstract: A system, method, and machine-readable storage medium for restoring a data object for a specified active time period are provided. In some embodiments, the method includes receiving, by a storage device from a client, a request specifying an active time period for a data object to remain stored on an accessible tier. The method also includes determining, by the storage device, that the active time period has elapsed. The method further includes responsive to a determination that the active time period has elapsed, sending, by the storage device, a request to a server storing the data object to move the data object from the accessible tier to an archive tier. Data objects that are stored on the accessible tier are accessible by the client, and data objects that are stored on the archive tier are inaccessible by the client.

Abstract: A method includes determining, by an analysis system, a system aspect of a system for an issue response communications evaluation. The method further includes determining, by the analysis system, at least one evaluation perspective and at least one evaluation viewpoint for use in performing the issue response communications evaluation on the system aspect. The method further includes obtaining, by the analysis system, issue response communications data regarding the system aspect in accordance with the at least one evaluation perspective and the at least one evaluation viewpoint. The method further includes calculating, by the analysis system, an issue response communications rating as a measure of system issue response communications maturity for the system aspect based on the issue response communications data, the at least one evaluation perspective, the at least one evaluation viewpoint, and at least one evaluation rating metric.

Abstract: A method and surgical system including a laser source for generating a pulsed laser beam, an imaging system including a detector, shared optics configured for directing the pulsed laser beam to an object to be sampled and confocally deflecting back-reflected light from the object to the detector, a patient interface, through which the pulsed laser beam is directed, the patient interface having, a cup with a large and small opening, and a notched ring inside the cup; and a controller operatively coupled to the laser source, the imaging system and the shared optics, the controller configured to align the eye for procedure.

Abstract: A receptacle includes an elongate barrel section defining a barrel length between an axial position pA and an axial position pB; side walls each having an inner surface bordering an interior; a layer of a lubricant located on the inner surface; and a charge present in the interior and sealing a cross section of the interior between the inner surfaces of the side walls. An axial position p+ is the axial position closest to pB at which the charge contacts the layer or the inner surfaces and an axial position p? is the axial position closest to pA at which the charge contacts the layer or the inner surfaces. The distance between pB and p+ divided by the distance between p+ and pA is in a range from 0 to 2 and a mean thickness of the layer between pA and p. is at least 10 nm.

Abstract: A system is provided with a controller configured to receive a computer model of a mold configured to cast a part. The computer model has a variable wall thickness of the mold thermally tailored to a geometry of the part. The controller is configured to control a manufacturing system to produce the mold based on the computer model.

Abstract: An adapter includes a substantially rigid body having a distal portion, a proximal portion, a central opening formed at least in part by an inner wall of the body, and a longitudinal axis extending substantially centrally through the opening. The distal portion includes an annular ring having a top surface and a ridge disposed opposite the top surface, the ridge extending substantially perpendicular to the longitudinal axis. The distal. The adapter also includes a seal configured to form a substantially fluid-tight seal with a surface of a fitting removably attachable to the adapter.

Abstract: An Ethernet switch and a switch microcontroller or CPU are integrated onto a system-on-a-chip (SoC). The Ethernet switch remains independently operating at full speed even though the remainder of the SoC is being reset or is otherwise nonoperational. The Ethernet switch is on a separated power and clock domain from the remainder of the integrated SoC. A warm reset signal is trapped by control microcontroller (MCU) to allow the switch CPU to isolate the Ethernet switch and save state. When the Ethernet switch is isolated and operating independently, the warm reset request is provided to the other entities on the integrated SoC. When warm reset is completed, the state is restored and the various DMA and flow settings redeveloped in the integrated SoC to allow return to normal operating condition.

Abstract: The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.

Abstract: This application relates to solabegron zwitterion useful for the treatment of lower urinary tract symptoms such as, for example, overactive bladder and prostate disorders. Additionally, this application relates to pharmaceutical compositions and methods of treatment utilizing the solabegron zwitterion for treating lower urinary tract symptoms. This application also relates to methods of preparing solabegron hydrochloride from the solabegron zwitterion.