Abstract: The present invention relates to a cognitive impairment determination apparatus (10), comprising: an input unit (20): a processing unit (30, 120); and an output unit (40). The input unit is configured to provide the processing unit with a plurality of first task trial results, wherein the plurality of first task trial results is generated by a patient having conducted a plurality of trials of a first task. The processing unit is configured to determine an index for the patient, wherein the determination of the index comprises a calculation of a representation of fluctuations in the plurality of first task trial results. The processing unit is configured to determine that the patient should undergo a scan of the brain, wherein the determination comprises utilization of the index for the patient. The output unit is configured to output information that the patient should undergo the scan of the brain if the processing unit determines that the patient should undergo the scan of the brain.

Abstract: A method and system for assessing a subject using fMRI analysis of the brain activity of a subject while they perform a set of cognitive tasks. For each task, a first level of performance in completing the task is derived. For at least some of the tasks which have been completed to a satisfactory level of performance, it is assessed if any of those tasks showed increased activity, above a threshold, of a region of the brain different to a region of the brain associated with the task. For those tasks, a further fMRI analysis is carried out while they perform a further cognitive task but with additional cognitive loading. The fMRI analysis and the further fMRI analysis are compared. This for example enables determination that a patient is using compensation mechanisms to complete the cognitive tasks.

Abstract: In order to improve MRI workflow, a recommender system is provided that comprises an input unit, a processing unit, and an output unit. The input unit is configured to receive data comprising information about a plurality of pre-tests provided to a patient and associated pre-test results. The plurality of pre-tests is performed prior to an MRI scan session. The plurality of pre-tests comprises a cognitive test, a sensorimotor test, or a combination thereof. The processing unit is configured to generate, based on the received data, a cognitive profile of the patient indicative of an individual's pattern of relative strengths and difficulties across several cognitive domains. The processing unit is further configured to determine, based on the cognitive profile of the patient, a task implementation for the MRI scan session. The processing unit is further configured to provide, via the output unit, a recommendation of the determined task implementation for the MRI scan session.

Abstract: Disclosed herein is a medical instrument (100) comprising a magnetic resonance imaging system (102) configured for acquiring k-space data (148, 152, 166) of a brain of a subject (118) with a missing limb (128) and a complementary limb (129) and a virtual reality system (122). The execution of machine executable instructions causes a computational system (132) to: identify (210) a complementary limb functional region (156) using functional magnetic resonance imaging and determine (212) a phantom limb functional region (158) in the brain by applying brain symmetry.

Abstract: A method and apparatus for use as part of diagnostic analysis of the psychiatric or neurological health of a patient based on use of a normative database of fMRI data results and cognitive task results for a population of prior patients. Embodiments propose to acquire fMRI data of a particular set of one or more regions of the brain of a patient while the patient is performing a cognitive task, and to record at the same time results of the patient's performance in the cognitive task. A combination of both the cognitive task results and the fMRI data for the brain regions is used to provide an indicator as to a cognitive health status of the patient. More particularly, a normative database of fMRI data results and cognitive task results for a population of patients is used as a reference. This may store results both for healthy patients and pathological patients, to provide a normal and abnormal reference.

Abstract: The present invention relates to a method (10) for monitoring the performance of a predetermined test task executed by a subject during an fMRI examination. The method comprises acquiring (11) a timeseries of fMRI images and providing (12) a sensory stimulus to the subject during the acquisition in accordance with the predetermined test task. The method comprises determining (13), after the sensory stimulus, an activity measure indicative of brain activity in at least one predetermined region of interest, and generating (14) at least one signal when the activity measure is indicative of a poor performance of and/or compliance to the predetermined test task. The signal is generated during the acquisition of the time series and/or before removing the subject from the magnetic resonance imaging system. Further aspects of the invention relate to computer program products, computer systems and MRI systems.

Abstract: In order to enable more accurate calibration of brain, there is provided a system for creating a hemodynamic brain atlas for calibration of brain hemodynamics. The system comprises a non-invasive transcranial neurostimulation device, a non-invasive neuromonitoring device, and a computing device. The non-invasive transcranial neurostimulation device is configured to induce neuronal activity to evoke a hemodynamic response in a target region of interest (ROI) of a brain of a human subject. The non-invasive neuromonitoring device is configured to monitor the evoked hemodynamic response in the target ROI. The computing device configured to determine a set of parameters representing a hemodynamic response function, HRF, of the evoked hemodynamic response in the target ROI, and to associate the set of parameters of the HRF with the target ROI to form the hemodynamic brain atlas.

Abstract: A system and method for controlling rhythmic sensory stimulation provided to a subject with post-stroke depression, PSD, during an MRI scan. A control unit is configured to control a rhythmic sensory stimulation signal such that the signal is rhythmically synchronous to a scanning rhythm of an MRI scanner performing the MRI scan.

Abstract: According to an aspect, there is provided a computer-implemented method for determining a sleep schedule (20; 40; 60) for a subject. The method comprises obtaining (101) information indicating a shift working pattern for the subject, the shift working pattern comprising at least one night shift, information indicating a required duration of sleep for the subject, and information relating to any personal activities to be undertaken by the subject during the day before or day after the at least one night shift. The method also comprises analyzing (103) the obtained information to determine a sleep schedule (20; 40; 60) for the subject. The sleep schedule (20; 40; 60) comprises two or more sleep windows in the day before or day after the at least one night shift in which the subject is to sleep, with the two or more sleep windows being scheduled according to the required duration of sleep for the subject and according to any personal activities to be undertaken by the subject.

Abstract: A system for treating visual neglect comprises a virtual reality headset and an input for receiving functional MRI, fMRI, scanner images. During an initial analysis phase, visual images are generated for presentation to the user via the virtual reality headset at different angular and depth positions relative to the user. The fMRI images are processed to monitor brain activity relating to visual perception, eye movement generation and visual awareness of an object in response to the generated visual images. In this way, a 3D map is derived of the visual awareness of the user, for use in treating the visual neglect.

Abstract: The present invention relates to attention bias modification treatment. In order to improve the treatment effect, an ABM system is proposed with a neural brain response monitoring device, such as functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and/or electroencephalography (EEG), to provide real-time information regarding neural brain responses in order to personalize and optimize the ABM treatment.

Abstract: Disclosed herein is a medical instrument (100, 300) comprising an activity measurement system (110, 301, 302) configured for measuring brain activity data (136) from a subject (102), a memory (120) storing machine executable instructions (130) and storing a simulation model (132), wherein the simulation model is configured to generating simulation data (134), wherein the simulation model is configured for modifying the simulation data using a model parameter (140), a virtual reality system (106, 106?, 106?, 106??, 106??) configured for rendering the simulation data; and a computational system (114) for controlling the medical instrument. Execution of the machine executable instructions causes the computational system to set (200) the model parameter to an initial value (142).

Abstract: The present invention relates to an apparatus (10) for determining and/or assessing depression severity of a patient. The apparatus comprising: an input unit (20); an image display unit (30); at least one sensor (40); and a processing unit (50). The image display unit is configured to present a plurality of images to a patient and the plurality of images are of different human facial expressions. The at least one sensor is configured to acquire information relating to the patients viewing of the plurality of images. The input unit is configured to provide the processing unit with the information relating to the patients viewing of the plurality of images. The input unit is configured to provide the processing unit with MRI scan image data of the patient. The MRI scan image data of the patient comprises MRI scan image data of at least one part of the patients brain associated with recognition of facial expressions and/or associated with affective disorders.

Abstract: A system and method for analyzing the brain activity of a subject during a transition between brain states. Brain activity data including data representative of a transition between brain states is received from a brain monitoring system and processed to obtain a value for one or more transition parameters. The one or more transition parameters are parameters that characterize the transition between brain states and may be used as a biomarker for identifying mental disorders.

Abstract: Disclosed herein is a medical system (200, 300) comprising an augmented reality system (204) configured for rendering virtual objects within a visual three-dimensional field of view of an operator (214).

Abstract: It is proposed to obtain information about a stress or anxiety level of a subject within a predetermined time period before, during and/or after a capture time of a fMRI scan image. Using this information, embodiments may provide additional/supplementary information that may aid, assist or otherwise improve interpretation of the fMRI scan image.

Abstract: Two subsequent fMRI images taken during or around an EMDR therapy treatment are compared. A change in a trauma level metric in relevant brain anatomy of a traumatized patient is determined and communicated, such that the success of the EMDR therapy can be more objectively assessed and/or the information may be used to tailor the EMDR therapy a during or after a therapy session.

Abstract: The present invention relates to an agenda generation system (10), comprising: at least one first sensor unit (20); an input unit (30); a processing unit (40); and at least one output unit (50); wherein the at least one first sensor unit is configured to acquire physiological data of a subject over an extended period of time prior to a current time point and provide the physiological data to the processing unit, wherein the physiological data is assigned to different times during the extended period of time, and wherein the physiological data comprises one or more of: heart rate, ventricular high rate, blood pressure, respiration rate, skin conductance, step count; wherein the at least one first sensor unit is configured to acquire sleep data of the subject over the extended period of time and provide the sleep data to the processing unit, wherein the sleep data is assigned to different times during the extended period of time, and wherein the sleep data comprises one or more of: duration of sleep; total d

Abstract: A system provides quality control in medical imaging Noise sources are evaluated which can adversely affect the image quality. The noise sources which are evaluated comprise at least two of a device noise source, an operator noise source and a subject (the patient being imaged) noise source, all creating sources of noise during the acquisition of the medical image. A quality control indicator is determined and output to the operator based on the evaluated noise sources.

Abstract: The present invention relates to an apparatus (10) for monitoring of a patient undergoing a Magnetic Resonance Image (MRI) scan. The apparatus comprises an input unit (20), a processing unit (30), and an output unit (40). The input unit is configured to provide the processing unit with at least one sensor data of a patient undergoing an MRI scan by an MRI scanner. The input unit is configured to provide the processing unit with at least one scan parameter of the MRI scanner for the MRI scan. The input unit is configured to provide the processing unit with at least one characteristic of the patient. The processing unit is configured to predict a stress level of the patient and/or a predicted motion state of the patient, the prediction or predictions comprising utilization of the at least one sensor data of the patient, the at least one scan parameter of the MRI scanner, and the at least one characteristic of the patient.