Patents by Inventor Raymond W Kosley

Raymond W Kosley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'piperidine] compounds
    Patent number: 4577026
    Abstract: Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: March 18, 1986
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
  • Intermediates for spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds
    Patent number: 4569998
    Abstract: Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: February 11, 1986
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
  • Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents
    Patent number: 4521537
    Abstract: Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.
    Type: Grant
    Filed: April 2, 1984
    Date of Patent: June 4, 1985
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
  • Analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines
    Patent number: 4518713
    Abstract: There are described analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines of the formula ##STR1## where X is hydrogen, loweralkyl, CF.sub.3, acetyl or halogen; n is 1 or 2; R.sub.1 is H.sub.2 or oxygen; R.sub.2 is H, loweralkyl or benzyl; and R.sub.3 is oxygen or --OCH.sub.2 CH.sub.2 O--, which are useful as analgesic agents and intermediate compounds therefor.
    Type: Grant
    Filed: April 13, 1984
    Date of Patent: May 21, 1985
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Richard C. Allen
  • Spiro (2H-1,4-benzodioxepin-3 (5H)4-piperidine and -3-pyrrolidine) compounds and their use as anti-hypertensive agents
    Patent number: 4472580
    Abstract: Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.
    Type: Grant
    Filed: July 25, 1983
    Date of Patent: September 18, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
  • Antihypertensive spiro[benzofuran-azalkanes]
    Patent number: 4452802
    Abstract: There are described antihypertensive spiro[benzofuran-azalkanes] of the formula ##STR1## where X is hydrogen or halogen (F, Cl, Br, or I); m and n are each 0, 1 or 2 but m plus n is 1 or 2; and R is ##STR2## k being 2 or 3 and Y being hydrogen or halogen, which are useful as antihypertensive agents and methods for synthesizing the same.
    Type: Grant
    Filed: August 25, 1983
    Date of Patent: June 5, 1984
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
  • Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'pyrrolidine] compounds and their use as antihypertensive agents
    Patent number: 4405631
    Abstract: Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3-pyrrolidine] compounds of the formula ##STR1## where the substituents are as defined herein, are useful in the treatment of hypertension in mammals. Such compounds, their use as antihypertensive agents, pharmaceutical compositions containing the compounds, intermediates and processes for preparing the compounds are provided.
    Type: Grant
    Filed: August 20, 1982
    Date of Patent: September 20, 1983
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Robert J. Cherill
  • Process for the preparation of 17(20)ene-21-steroid aldehydes
    Patent number: 4059575
    Abstract: There is disclosed a process for the efficient conversion of 17-.alpha.-ethynyl 17-.beta.- hydroxy steroids into the corresponding 17(20) .alpha..beta.-unsaturated 21-steroid aldehydes. The process comprises the sequential steps of reacting the ethynyl alcohol with a diloweralkylformamide dilower-alkylacetal, suitably dimethylformamide diethylacetal, to form the corresponding 16,20 diene-21-diloweralkylamine which is then hydrolyzed to form the corresponding 17(20)-ene-21-steroid aldehyde.
    Type: Grant
    Filed: April 22, 1976
    Date of Patent: November 22, 1977
    Assignee: Research Corporation
    Inventors: Kathlyn A. Parker, Raymond W. Kosley, Jr.
  • Method of tranquilizing and treating pain
    Patent number: 3985889
    Abstract: Novel substituted 1,3-dihydrospiro[isobenzofuran]s and methods of preparing the same are described. These compounds are useful as tranquilizers, analgetic agents and intermediates therefor.
    Type: Grant
    Filed: July 1, 1975
    Date of Patent: October 12, 1976
    Assignee: American Hoechst Corporation
    Inventors: Victor J. Bauer, Raymond W. Kosley, Jr.
  • 1,3-Dihydrospiro[isobenzofuran]s and derivatives thereof
    Patent number: 3962259
    Abstract: Novel substituted 1,3-dihydrospiro[isobenzofuran]s and methods of preparing the same are described. These compounds are useful as tranquilizers, analgetic agents and intermediates therefor.
    Type: Grant
    Filed: December 12, 1973
    Date of Patent: June 8, 1976
    Assignee: American Hoechst Corporation
    Inventors: Victor J. Bauer, Raymond W. Kosley, Jr.
  • Substituted 1,3-dihydrospiro(isobenzofuran)s
    Patent number: 3959475
    Abstract: Novel substituted 1,3-dihydrospiro[isobenzofuran]s and methods of preparing the same are described. These compounds are useful as antidepressants, tranquilizers, analgetic agents and intermediates therefor.
    Type: Grant
    Filed: September 3, 1974
    Date of Patent: May 25, 1976
    Assignee: American Hoechst Corporation
    Inventors: Victor J. Bauer, Raymond W. Kosley, Jr.