Patents by Inventor Raymond W Sweet

Raymond W Sweet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders
    Publication number: 20030215450
    Abstract: Chimeric, humanized and other RANK-L mAbs, derived from high affinity neutralizing mAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Application
    Filed: November 21, 2002
    Publication date: November 20, 2003
    Inventors: Simon M Blake, Raymond W Sweet, Alexander H Taylor, Trevor A Wattam
  • Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders
    Publication number: 20030211106
    Abstract: Chimeric, humanized and other RANK-L MAbs, derived from high affinity neutralizing MAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
    Type: Application
    Filed: February 19, 2003
    Publication date: November 13, 2003
    Inventors: Mark A Tornetta, Raymond W Sweet, Alemseged Truneh, Tervor a Wattam
  • Hexameric fusion proteins and uses therefor
    Publication number: 20020147326
    Abstract: An hexameric fusion protein containing a dimeric binding protein provided with a tailpiece from an IgA antibody is described. This fusion protein is useful in therapeutics and vaccines, but is particularly well suited for applications for which the binding protein from which it is derived is unsatisfactory because of low binding affinity or for applications where multivalency is desired. These applications include diagnostics, binding assays and screening assays.
    Type: Application
    Filed: April 30, 2001
    Publication date: October 10, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Margery Ann Chaikin, Sally Doreen Patricia Lyn, Raymond W. Sweet, Alemseged Truneh
  • PIGR-1, a member of immunoglobulin gene superfamily
    Patent number: 6232441
    Abstract: PIGR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGR-1 polypeptides and polynucleotides in the design of protocols for the treatment of rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: May 15, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Shujian Wu, Raymond W Sweet, Alemseged Truneh, Mark Robert Hurle
  • PIGRL-1, a member of immunoglobulin gene superfamily
    Patent number: 6114515
    Abstract: PIGRL-1 polypeptide and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGRL-1 polypeptide and polynucleotides in the design of protocols for the treatment of Hyper-IgM Immunodeficiency (HIM), X-linked Severe Combined Immunodeficiency (XSCID), and IgA deficiency (IgA-D), among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: September 5, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Shujian Wu, Raymond W. Sweet, Alemseged Truneh
  • Human LIG-1 homolog (HLIG-1)
    Patent number: 6046030
    Abstract: HLIG-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HLIG-1 polypeptides and polynucleotides in the design of protocols for the treatment of neurological disorders such as Alzheimer's disease, multiple sclerosis and abnormal neural development; endocrine disorders such as diabetes; and heart disease, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: April 4, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Shujian Wu, Raymond W Sweet, Alemseged Truneh
  • PIGR-1, a member of immunoglobulin gene superfamily
    Patent number: 6020161
    Abstract: PIGR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGR-1 polypeptides and polynucleotides in the design of protocols for the treatment of rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: February 1, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Shujian Wu, Raymond W Sweet, Alemseged Truneh, Mark Robert Hurle
  • Internal deletion mutants of soluble T4(CD4)
    Patent number: 5422274
    Abstract: This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide has the amino acid sequence shown in FIG. 6 from about +1 to about +185.This invention also provides a method for treating a subject infected with a human immunodeficiency virus.
    Type: Grant
    Filed: February 5, 1992
    Date of Patent: June 6, 1995
    Assignees: The Trustees of Columbia University in the City of New York, SmithKline Beckman Corporation
    Inventors: Paul J. Maddon, Richard Axel, Raymond W. Sweet, James Arthos
  • Derivatives of soluble T-4
    Patent number: 5110906
    Abstract: This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185 fused to the amino acid sequence from about +353 to about +371. In another embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +106 fused to the amino acid sequence from about +353 to about +371. In yet a further embodiment of the invention, the amino acid sequence of the polypeptide comprises the amino acid sequence shown in FIG. 6 from about +1 to about +185.This invention also provides a method for treating a subject infected with a human immunodeficiency virus.
    Type: Grant
    Filed: February 24, 1988
    Date of Patent: May 5, 1992
    Assignees: The Trustees of Columbia University in the City of New York, Smithkline Beckman Corporation
    Inventors: Paul J. Maddon, Richard Axel, Raymond W. Sweet, James Arthos