Patents by Inventor Raymond Walker
Raymond Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132578Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.Type: ApplicationFiled: August 18, 2023Publication date: April 25, 2024Inventors: Po-Ying Chan-Hui, Katherine Doores, Michael Huber, Stephen Kaminsky, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Majorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
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Patent number: 11911372Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 28, 2019Date of Patent: February 27, 2024Assignee: CTXT PTY LTDInventors: Paul Anthony Stupple, Helen Rachel Lagiakos, Richard Charles Foitzik, Michelle Ang Camerino, George Nikolakopoulos, Ylva Elisabet Bergman Bozikis, Wilhelmus Johannes Antonius Kersten, Scott Raymond Walker, Jonathan Grant Hubert
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Publication number: 20230393860Abstract: A computer-implemented method, including monitoring, by a computing device, usage data of an application on a primary user device; detecting, by the computing device, a mirroring of the application on a secondary user device based on an identification of the application; determining, by the computing device, a synchronization setting of the application including a secondary user device based on a historical synchronization data for the application; and generating, by the computing device, a synchronization configuration for the application on the secondary user device based on the usage data; and synchronizing, by the computing device, the application on the secondary user device with the synchronization configuration.Type: ApplicationFiled: June 3, 2022Publication date: December 7, 2023Inventors: Keith Raymond Walker, Martin G. Keen, John M. Ganci, JR., Sarbajit K. Rakshit
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Publication number: 20230227423Abstract: A compound of formula (I): wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).Type: ApplicationFiled: January 31, 2023Publication date: July 20, 2023Inventors: Benjamin Joseph Morrow, Michelle Ang Camerino, Scott Raymond Walker, Graeme Irvine Stevenson, Paul Anthony Stupple
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Publication number: 20230130195Abstract: A method of reducing symptoms of neurodegenerative disease in a human is provided. The method comprises applying to the human a solution or salve to at least one of the skin, the mouth, the nasal cavities, the lungs, the eyes, or the vagina of the human. The applied solution or salve comprises an effective amount of an isomerized or conjugated linoleic acid cation salt having a conjugated diene for at least a measurable improvement in the movement or mental acuity of the human and a structure of -C=C-C=C-. The measurable improvement in the movement or mental acuity of the human is within 4-6 weeks of the applying of the solution or salve. A method of making the conjugated diene and a device for measuring the reduction of systems is also provided.Type: ApplicationFiled: September 27, 2022Publication date: April 27, 2023Inventors: David G. Changaris, Raymond Walker
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Patent number: 11613525Abstract: A compound of formula (I), wherein R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).Type: GrantFiled: May 16, 2019Date of Patent: March 28, 2023Assignee: CTXT PTY LIMITEDInventors: Benjamin Joseph Morrow, Michelle Ang Camerino, Scott Raymond Walker, Graeme Irvine Stevenson, Paul Anthony Stupple
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Publication number: 20220153710Abstract: A compound of formula (I), or a pharmaceutical salt thereof:Type: ApplicationFiled: August 3, 2021Publication date: May 19, 2022Inventors: H. Rachel Lagiakos, Benjamin Joseph Morrow, Richard Charles Foitzik, Catherine Fae Hemley, Michelle Ang Camerino, Paul Anthony Stupple, Ylva Elisabet Bergman Bozikis, Scott Raymond Walker
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Publication number: 20210380548Abstract: A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1, and MOF.Type: ApplicationFiled: August 31, 2018Publication date: December 9, 2021Inventors: Benjamin Joseph Morrow, Richard Charles Foitzik, Michelle Ang Camerino, H. Rachel Lagiakos, Scott Raymond Walker, Ylva Elisabet Bergman Bozikis, Graeme Irvine Stevenson, Anthony Nicholas Cuzzupe, Paul Anthony Stupple
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Publication number: 20210213004Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: June 28, 2019Publication date: July 15, 2021Inventors: Paul Anthony Stupple, Helen Rachel Lagiakos, Richard Charles Foitzik, Michelle Ang Camerino, George Nikolakopoulos, Ylva Elisabet Bergman Bozikis, Wilhelmus Johannes Antonius Kersten, Scott Raymond Walker, Jonathan Grant Hubert
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Publication number: 20210214333Abstract: A compound of formula (I), wherein R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).Type: ApplicationFiled: May 16, 2019Publication date: July 15, 2021Inventors: Benjamin Joseph Morrow, Michelle Ang Camerino, Scott Raymond Walker, Graeme Irvine Stevenson, Paul Anthony Stupple
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Patent number: 10961256Abstract: A compound of formula (Ia), (Ib) or (Ic) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(?O)NH2, and —CH2OH; R4b is either H or Me; X is either N or CH; R7 is selected from H and C1-4 alkyl; (a) one of R8a, R8b, R8c and R8d is selected from H, halo, C1-4 alkyl, C1-4 alkoxy, NHC1-4 alkyl; (b) another of R8a, R8b, R8c and R8d is selected from H, C1-4 alkyl, C1-4 fluoroalkyl, C3-6 cycloalkyl, C5-6 heteroaryl, C5-6 heteroaryl methyl, C4-6 heterocyclyl, C4-6 heterocyclyl methyl, phenyl, benzyl, halo, amido, amidomethyl, acylamido, acylamidomethyl, C1-4 alkyl ester, C1-4 alkyl ester methyl, C1-4 alkyl carbamoyl, C1-4 alkyl carbamoyl methyl, C1-4 alkylacyl, C1-Type: GrantFiled: March 9, 2017Date of Patent: March 30, 2021Assignee: CTXT PTY LTDInventors: Paul Anthony Stupple, Scott Raymond Walker, Michelle Ang Camerino
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Patent number: 10865644Abstract: A rotor for use in an aircraft engine, that has been repaired by (a) welding together a first portion of a damaged blade of the rotor and a second portion of metal to form a weld nugget, (b) compressively stressing the weld nugget throughout its volume, and (c) heat treating the compressively stressed weld nugget to recrystallize metal therein.Type: GrantFiled: March 23, 2017Date of Patent: December 15, 2020Assignee: KEYSTONE SYNERGISTIC ENTERPRISES, INC.Inventors: Bryant Walker, Raymond Walker
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Patent number: 10647708Abstract: A compound of formula (I) wherein: R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.Type: GrantFiled: September 3, 2015Date of Patent: May 12, 2020Assignee: CTXT PTY. LTDInventors: Richard Charles Foitzik, Michelle Ang Camerino, Scott Raymond Walker, H. Rachel Lagiakos
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Publication number: 20200039945Abstract: A compound of formula (I), or a pharmaceutical salt thereof:Type: ApplicationFiled: June 20, 2019Publication date: February 6, 2020Applicant: CTxT Pty LimitedInventors: Helen Rachel Lagiakos, Benjamin Joseph Morrow, Richard Charles Foitzik, Catherine Fae Hemley, Michelle Ang Camerino, Paul Anthony Stupple, Ylva Elisabet Bergman Bozikis, Scott Raymond Walker
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Patent number: 10550096Abstract: A compound of formula (I) wherein: n is 1 or 2; p is 0 or 1; R1a, R1b, R1c and R1d are independently selected from H, halo, methyl and methoxy; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2e is H or Me; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R6a and R6b are independently selected from H and Me; X is either N or CH; R7 is selected from H and C1-4 alkyl; (a) one of R8a, R8b, R8c, and R8d is selected from H, halo, C1-4 alkyl, C1-4 alkoxy, NHC1-4 alkyl; (b) another of R8a, R8b, R8c and R8d is selected from H, C1-4 alkyl, C1-4 fluoroalkyl, C3-6 cycloalkyl, C5-6 heteroaryl, C5-6 heteroaryl methyl, C4-6 heterocyclyl, C4-6 heterocyclyl methyl, phenyl, benzyl, halo, amido, amidomethyl, acylamido, acylamidomethyl, C1-4 alkyl ester, C1-4 alkyl ester methyl, C1-4 alkyl carbamoyl, C1-4 alkyl carbamoyl methyl, C1Type: GrantFiled: March 9, 2017Date of Patent: February 4, 2020Assignee: CTXT PTY LTDInventors: Alexandra Elizabeth Stupple, Scott Raymond Walker, Paul Anthony Stupple
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Publication number: 20200002355Abstract: A compound of formula (Ia), (Ib) or (Ic) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(?O)NH2, and —CH2OH; R4b is either H or Me; X is either N or CH; R7 is selected from H and C1-4 alkyl; (a) one of R8a, R8b, R8c and R8d is selected from H, halo, C1-4 alkyl, C1-4 alkoxy, NHC1-4 alkyl; (b) another of R8a, R8b, R8c and R8d is selected from H, C1-4 alkyl, C1-4 fluoroalkyl, C3-6 cycloalkyl, C5-6 heteroaryl, C5-6 heteroaryl methyl, C4-6 heterocyclyl, C4-6 heterocyclyl methyl, phenyl, benzyl, halo, amido, amidomethyl, acylamido, acylamidomethyl, C1-4 alkyl ester, C1-4 alkyl ester methyl, C1-4 alkyl carbamoyl, C1-4 alkyl carbamoyl methyl, C1-4 alkylacyl, C1-Type: ApplicationFiled: March 9, 2017Publication date: January 2, 2020Inventors: Paul Anthony Stupple, Scott Raymond Walker, Michelle Ang Camerino
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Patent number: 10494376Abstract: A compound of formula I wherein: n is 1 or 2: p is 0 or 1; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl.Type: GrantFiled: September 3, 2015Date of Patent: December 3, 2019Assignee: CTXT PTY. LTD.Inventors: Ylva Elisabet Bergman, Richard Charles Foitzik, Benjamin Joseph Morrow, Michelle Ang Camerino, Scott Raymond Walker, H. Rachel Lagiakos, John Feutrill, Graeme Irvine Stevenson, Paul Anthony Stupple
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Patent number: 10421743Abstract: A compound of formula (I) wherein: n is 1 or 2; p is 0 or 1; R1a, R1b, R1c and R1d are independently selected from the group consisting of H, halo, C1-4 alkoxy, C1-4 alkyl, C1-4 fluoroalkyl, C3-4 cycloalkyl, NH—C1-4 alkyl and cyano; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2e is H or Me; R3a and R3b are independently selected from H and Me; R4 is either H or Me; R5 is either H or Me; R6a and R6b are independently selected from H and Me; A is either (i) optionally substituted phenyl; (ii) optionally substituted naphthyl; or (iii) optionally substituted C5-12 heteroaryl; wherein when R2e is H, at least one of R1a, R1b, R1c and R1d is selected from C1-4 alkoxy, C2-4 alkyl, C1-4 fluoroalkyl, C3-4 cycloalkyl, NH—C1-4 alkyl and cyano.Type: GrantFiled: March 9, 2017Date of Patent: September 24, 2019Assignee: CTXT PTY LTDInventors: Ylva Elisabet Bergman, Michelle Ang Camerino, Scott Raymond Walker, Paul Anthony Stupple
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Patent number: 10416995Abstract: A technique for providing environmental impact information associated with code includes determining, based on execution of the code on a computer system, an environmental impact of a code execution sequence included in the code. A section of the code that is associated with the code execution sequence is then annotated with environmental impact information associated with the environmental impact of the code execution sequence.Type: GrantFiled: April 1, 2016Date of Patent: September 17, 2019Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Rick Allen Hamilton, II, James R. Kozloski, Brian Marshall O'Connell, Clifford Alan Pickover, Keith Raymond Walker
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Patent number: 10345922Abstract: A computer implemented method, apparatus, and computer usable program code for embedding and importing content prediction instructions. Content prediction instructions are customized. The content prediction instruction is part of content prediction logic. The prediction instruction is embedded in a document in response to receiving a user selection to embed the prediction instruction.Type: GrantFiled: April 21, 2006Date of Patent: July 9, 2019Assignee: International Business Machines CorporationInventors: Yen-Fu Chen, John Hans Handy-Bosma, Susan Elise Lee, Keith Raymond Walker