Abstract: Two-component vaccine formulations and methods are contemplated where the vaccine has an adjuvant component and a therapeutic component. The therapeutic component comprises preferably a recombinant therapeutic virus encoding a therapeutic antigen while the adjuvant component comprises a non-host cell or immune stimulating portion thereof. Notably, use of the adjuvant component will result in significant uptake of the therapeutic component into immune competent cells, even in the absence of receptors for entry of the therapeutic component. In addition, such adjuvant also stimulates expression of the therapeutic antigen.

Abstract: Two-component vaccine formulations and methods are contemplated where the vaccine has an adjuvant component and a therapeutic component. The therapeutic component comprises preferably a recombinant therapeutic virus encoding a therapeutic antigen while the adjuvant component comprises a non-host cell or immune stimulating portion thereof. Notably, use of the adjuvant component will result in significant uptake of the therapeutic component into immune competent cells, even in the absence of receptors for entry of the therapeutic component. In addition, such adjuvant also stimulates expression of the therapeutic antigen.

Abstract: Two-component vaccine formulations and methods are contemplated where the vaccine has an adjuvant component and a therapeutic component. The therapeutic component comprises preferably a recombinant therapeutic virus encoding a therapeutic antigen while the adjuvant component comprises a non-host cell or immune stimulating portion thereof. Notably, use of the adjuvant component will result in significant uptake of the therapeutic component into immune competent cells, even in the absence of receptors for entry of the therapeutic component. In addition, such adjuvant also stimulates expression of the therapeutic antigen.

Abstract: A trace assist unit operable with a plurality of processor cores is described. The trace assist unit comprises a plurality of physical buffers, and loading circuitry and unloading circuitry that are communicatively coupled with the plurality of physical buffers. The loading circuitry receives trace events from various ones of the plurality of processor cores, each of the trace events having a respective category from a plurality of predefined categories. The loading circuitry writes the trace events to respective ones of the plurality of physical buffers that are assigned to the respective categories of the plurality of predefined categories. The loading circuitry transmits, responsive to one or more predefined conditions, an unload signal to the unloading circuitry to unload contents of a selected physical buffer of the plurality of physical buffers to an external memory.

Abstract: An epoxy-based resin composition for clear fiber composites includes epoxy resins and an anhydride curing agent. The epoxy resins include at least one epoxy resin having a refractive index higher than a refractive index of glass fibers, and at least one cycloaliphatic epoxy resin. The amount of non-aromatic components in the epoxy-based resin composition is 60 wt % or higher, based on the total amount of the epoxy resins and the anhydride curing agent. An epoxy-based clear fiber composite for a cover plate in a solar cell panel includes a cured matrix resin and a fiber reinforcement. The epoxy-based clear fiber composite has a refractive index ranging from 1.520 to 1.530 or 1.550 to 1.565, while the difference between the refractive index of the fiber reinforcement and the cured matrix resin is 0.001 or less. A multi-layer epoxy-based clear fiber composite includes a plurality of the epoxy-based clear fiber composite.

Abstract: Current thermostat data including room temperature readings, thermostat control commands, and user input temperature set point changes is collected. The current thermostat data is sent from a thermostat to a cloud server that creates and continually updates a first server machine learning model trained using previous and the current thermostat data, a second thermostat machine learning model is created for sending control commands to the thermostat using the previous and the current thermostat data, and the second thermostat machine learning model is updated. The second thermostat machine learning model is updated by sending updated model parameters from the first server machine learning model to the second thermostat machine learning model. One or more new thermostat commands determined from the current thermostat data are received from the second thermostat machine learning model and the one or more new thermostat commands are executed.

Abstract: Two-component vaccine formulations and methods are contemplated where the vaccine has an adjuvant component and a therapeutic component. The therapeutic component comprises preferably a recombinant therapeutic virus encoding a therapeutic antigen while the adjuvant component comprises a non-host cell or immune stimulating portion thereof. Notably, use of the adjuvant component will result in significant uptake of the therapeutic component into immune competent cells, even in the absence of receptors for entry of the therapeutic component. In addition, such adjuvant also stimulates expression of the therapeutic antigen.

Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.

Abstract: A method, a system, and computer program product for managing upgrades of cloud-based software applications are provided. A request to convert assets is received. Historical data and current data associated with the assets is retrieved. A conversion score is generated for converting the one or more assets. The conversion score includes a weighted sum of a plurality of risk scores, each of the plurality of risk scores being determined by using a machine learning model including a convolution function configured to process the historical data and the current data. A conversion of the assets is selectively enabled based on a comparison of the conversion score to a threshold. Current data associated with the assets is updated and display based on the conversion.

Abstract: Antibodies, fragments thereof, and chimeric proteins comprising the same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.

Abstract: Two-component vaccine formulations and methods are contemplated where the vaccine has an adjuvant component and a therapeutic component. The therapeutic component comprises preferably a recombinant therapeutic virus encoding a therapeutic antigen while the adjuvant component comprises a non-host cell or immune stimulating portion thereof. Notably, use of the adjuvant component will result in significant uptake of the therapeutic component into immune competent cells, even in the absence of receptors for entry of the therapeutic component. In addition, such adjuvant also stimulates expression of the therapeutic antigen.

Abstract: A smart thermostatic system is disclosed that applies one or more of a reinforcement and/or adaptive learning model for a new environment with the trained model from another environment so as to initiate status of a thermostatic device. In one example, the thermostatic system uses a pretrained machine learning model that is transferred from a first thermostatic system to a second thermostatic system in a similar sub-environment. Temperature data and other data collected by the thermostatic device is used to fine-tune and train the pretrained model to learn, predict, and better adjust the operation of the thermostatic system.

Abstract: A semiconductor package including a lead frame, an Ag plated surface positioned on the lead frame, an adhesion promotion layer positioned on the top of the Ag plated surface, and mold body covering the top of the lead frame is provided. The Ag plated surface covers a significant part of an interconnection area of the lead frame surface, and the Ag plating surface does not exceed the area of the mold body.

Abstract: Apparatuses, systems, and techniques for supporting fairness of multiple context sharing cryptographic hardware. An accelerator circuit includes a copy engine (CE) with AES-GCM hardware configured to perform both encryption and authentication of data transfers for multiple applications or multiple data streams in a single application or belonging to a single user. The CE splits a data transfer of a specified size into a set of partial transfers. The CE sequentially executes the set of partial transfers using a context for a period of time (e.g., a timeslice) for an application. The CE stores in a secure memory for the application one or more data for encryption or decryption (e.g., a hash key, a block counter, etc.) computed from a last partial transfer. The one or more data for encryption or decryption are retrieved and used when data transfers for the application is resumed by the CE.

Abstract: An ergonomic power supply for a computer system includes a printed circuit board assembly configured to convert a mains electricity input to voltage-regulated, direct-current (DC) outputs. The printed circuit board assembly defines a mains input and has one or more DC output connectors. An enclosure houses a fan and the printed circuit board assembly. The enclosure has a rear panel, a front panel positioned opposite the rear panel relative to the printed circuit board assembly. A side panel is positioned between the front and rear panel. The mains connector extends through an aperture defined by the rear panel of the enclosure. The one or more DC output connectors extend through the side panel. Such an arrangement provides significantly easier access to the power supply outputs compared to conventional power supplies. Associated computer systems also are described.

Abstract: Apparatuses, systems, and techniques for supporting fairness of multiple context sharing cryptographic hardware. An accelerator circuit includes a copy engine (CE) with AES-GCM hardware configured to perform both encryption and authentication of data transfers for multiple applications or multiple data streams in a single application or belonging to a single user. The CE splits a data transfer of a specified size into a set of partial transfers. The CE sequentially executes the set of partial transfers using a context for a period of time (e.g., a timeslice) for an application. The CE stores in a secure memory for the application one or more data for encryption or decryption (e.g., a hash key, a block counter, etc.) computed from a last partial transfer. The one or more data for encryption or decryption are retrieved and used when data transfers for the application is resumed by the CE.

Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.

Abstract: Antibodies, fragments thereof, and chimeric proteins comprising same are presented that have specific binding activity against T-cell immunoglobulin mucin receptor 3 (TIM3). Advantageously, contemplated molecules can be used in pharmaceutical compositions for immune therapy, particularly in individuals receiving cancer vaccines and/or checkpoint inhibitor treatment.

Abstract: The subject application relates to computing an authentication tag for partial transfers scheduled across multiple direct memory access (DMA) engines. Apparatuses, systems, and techniques are described for computing an authentication tag for a data transfer when the data transfer is scheduled as partial transfers across a specified number of direct memory access (DMA) engines. An orchestration circuit stores partial authentication tags, computed by the DMA engines, and corresponding adjustment exponents during one or more rounds in which the partial transfers are scheduled and processed by the specified number of DMA engines. During a last round, a combined authentication tag can be computed based on the partial authentication tags and the corresponding adjustment exponents stored by the orchestration circuit during the rounds.

Abstract: A novel combustion chamber valve and fuel system for driven fastener hand tool is disclosed having a fuel pump disposed parallel to the combustion and piston chambers. Pressure applied a safety at the nose of the tool is activates the fuel pump in a common direction. Pressure applied on a trigger activates the valve system prior to firing in a common direction. The valve system employs a central shaft coupling three valves, an inlet valve using a novel wedged circumferential edge seal, a control valve using a novel edge circumferential seal with a ventilated support, and a charging exhaust valve using a face seal.