Patents by Inventor Rayomand H. Gimi
Rayomand H. Gimi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11744845Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.Type: GrantFiled: June 4, 2021Date of Patent: September 5, 2023Assignee: F-star Therapeutics, Inc.Inventors: Radhakrishnan P. Iyer, Anjaneyulu Sheri, Seetharamaiyer Padmanabhan, Geeta Meher, Shenghua Zhou, Sreerupa Challa, Rayomand H. Gimi, Dillon Cleary
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Publication number: 20230271999Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.Type: ApplicationFiled: January 20, 2023Publication date: August 31, 2023Inventors: Radhakrishnan P. Iyer, Geeta Meher, Anjaneyulu Sheri, Shenghua Zhou, Sreerupa Challa, Rayomand H. Gimi, Seetharamaiyer Padmanabhan, Dillon Cleary
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Patent number: 11584774Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.Type: GrantFiled: September 11, 2018Date of Patent: February 21, 2023Assignee: F-star Therapeutics, Inc.Inventors: Radhakrishnan P. Iyer, Geeta Meher, Anjaneyulu Sheri, Shenghua Zhou, Sreerupa Challa, Rayomand H. Gimi, Seetharamaiyer Padmanabhan, Dillon Cleary
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Publication number: 20220168309Abstract: Disclosed are compounds and compositions for inhibiting the expression of a pattern recognition receptor (e.g., STING), and methods of use thereof.Type: ApplicationFiled: March 5, 2020Publication date: June 2, 2022Inventors: RADHAKRISHNAN P. IYER, SEETHARAMAIYER PADMANABHAN, SUBRAMANIAN BASKARAN, ANJANEYULU SHERI, DILLON CLEARY, RON MASTROLIA, SHENGHUA ZHOU, SREERUPA CHALLA, RAYOMAND H. GIMI, VISHAL NAIR, LEENA PRABA SUPPIAH
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Publication number: 20220054523Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.Type: ApplicationFiled: June 4, 2021Publication date: February 24, 2022Inventors: Radhakrishnan P. Iyer, Anjaneyulu Sheri, Seetharamaiyer Padmanabhan, Geeta Meher, Shenghua Zhou, Sreerupa Challa, Rayomand H. Gimi, Dillon Cleary
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Patent number: 11033569Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.Type: GrantFiled: July 6, 2017Date of Patent: June 15, 2021Assignee: Sperovie Biosciences, Inc.Inventors: Radhakrishnan P. Iyer, Anjaneyulu Sheri, Seetharamaiyer Padmanabhan, Geeta Meher, Shenghua Zhou, Sreerupa Challa, Rayomand H. Gimi, Dillon Cleary
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Publication number: 20200270299Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.Type: ApplicationFiled: September 11, 2018Publication date: August 27, 2020Inventors: Radhakrishnan P. Iyer, Geeta Meher, Anjaneyulu Sheri, Shenghua Zhou, Sreerupa Challa, Rayomand H. Gimi, Seetharamaiyer Padmanabhan, Dillon Cleary
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Publication number: 20190290673Abstract: This invention relates to methods useful in the treatment of a hepatitis infection.Type: ApplicationFiled: October 24, 2017Publication date: September 26, 2019Inventors: Radhakrishnan P. Iyer, Rayomand H. Gimi
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Publication number: 20190292215Abstract: Disclosed are compounds and compositions for the induction of expression of a pattern recognition receptor (e.g., STING) and methods of use thereof.Type: ApplicationFiled: July 14, 2017Publication date: September 26, 2019Inventors: Radhakrishnan P. Iyer, Seetharamaiyer Padmanabhan, Dillon Cleary, Geeta Meher, Rayomand H. Gimi, Anjaneyulu Sheri, Shenghua Zhou, Sreerupa Challa
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Publication number: 20190262372Abstract: Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.Type: ApplicationFiled: July 6, 2017Publication date: August 29, 2019Inventors: Radhakrishnan P. Iyer, Anjaneyulu Sheri, Seetharamaiyer Padmanabhan, Geeta Meher, Shenghua Zhou, Sreerupa Challa, Rayomand H. Gimi, Dillon Cleary
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Publication number: 20100234309Abstract: Amine compounds, amine polymers, crosslinked amine polymers and pharmaceutical compositions comprising the same may include polyhydroxy-containing cores that may be substituted with amine groups and may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.Type: ApplicationFiled: August 31, 2007Publication date: September 16, 2010Applicant: Genzyme CorporationInventors: Christopher Cooper, Pradeep K. Dhal, Rayomand H. Gimi, David J. Harris, Stephen Randall Holmes-Farley, Chad C. Huval, Edward Lee
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Patent number: 7285670Abstract: A useful and efficient method of preparing an alkylated thiazoline carboxylic acid, or a derivative thereof, comprises coupling a substituted aryl nitrile such as, for example, 2,4-dimethoxybenzonitrile or 4-methoxybenzonitrile, with a cysteine ester to form a substituted thiazoline carboxylic acid ester; optionally hydrolyzing the substituted thiazoline carboxylic acid ester to form a substituted thiazoline carboxylic acid; optionally, protecting the carboxyl group; alkylating the thiazoline ring at the 4-carbon position, as indicated in Structural Formula (I), with a compound of the formula R1-L, wherein R1 is as defined above and L is a leaving group, in the presence of a phase transfer catalyst; and, optionally, deprotecting the carboxyl group. In one embodiment of the present invention, a cinchona-alkaloid derived phase transfer catalyst is used to alkylate a protected substituted thiazoline carboxylic acid.Type: GrantFiled: October 3, 2005Date of Patent: October 23, 2007Assignee: Genzyme CorporationInventors: Mukund S. Chorghade, Rayomand H. Gimi, Peter D. McDonnell, Paul Wolstenholme-Hogg
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Patent number: 7115769Abstract: Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention provides methods of preparing 2-alkylcysteine derivatives. In another embodiment, the method comprises forming a 2-alkylcysteine derivative from a cysteine derivative in the presence of a phase transfer catalyst. In particular, the present invention provides methods for preparing 2-methylcysteine derivatives. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In one aspect, an aryl nitrile or imidate is condensed with cysteine or a 2-alkyl cysteine. The present invention also relates to the preparation of 4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-alkyl-thiazole-4-carboxylic acids, such as 4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-methyl-thiazole-4-carboxylic acid.Type: GrantFiled: May 15, 2003Date of Patent: October 3, 2006Assignee: Genzyme CorporationInventors: Rayomand H. Gimi, Mukund S. Chorghade
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Patent number: 6982335Abstract: A useful and efficient method of preparing an alkylated thiazoline carboxylic acid, or a derivative thereof, comprises coupling a substituted aryl nitrile such as, for example, 2,4-dimethoxybenzonitrile or 4-methoxybenzonitrile, with a cysteine ester to form a substituted thiazoline carboxylic acid ester; optionally hydrolyzing the substituted thiazoline carboxylic acid ester to form a substituted thiazoline carboxylic acid; optionally, protecting the carboxyl group; alkylating the thiazoline ring at the 4-carbon position, as indicated in Structural Formula (I), with a compound of the formula R1-L, wherein R1 is as defined above and L is a leaving group, in the presence of a phase transfer catalyst; and, optionally, deprotecting the carboxyl group. In one embodiment of the present invention, a cinchona-alkaloid derived phase transfer catalyst is used to alkylate a protected substituted thiazoline carboxylic acid.Type: GrantFiled: May 15, 2003Date of Patent: January 3, 2006Assignee: Genzyme CorporationInventors: Mukund S. Chorghade, Rayomand H. Gimi, Peter D. McDonnell, Paul Wolstenholme-Hogg
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Patent number: 6878828Abstract: Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention relates to a method of preparing a 2-alkylcysteine comprising condensing cysteine with an aryl nitrile to form a 2-arylthiazoline-4-carboxylic acid, esterifying the 2-arylthiazoline-4-carboxylic acid using a substituted or unsubstituted alcohol group comprising one or more chiral carbons, and alkylating at the 4-position of the thiazoline ring to form a 2-aryl-4-alkyl-thiazoline-4-carboxylic acid ester. The chiral templates present in the thiazoline carboxylic acid ester can provide face selectivity, and consequently desired stereochemistry, during the delivery of an alkyl group to the 4-position of the thiazoline ring. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring.Type: GrantFiled: May 15, 2003Date of Patent: April 12, 2005Assignee: Genzyme CorporationInventors: Rayomand H. Gimi, Mukund S. Chorghade, Sunil V. Mhaskar
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Patent number: 6794515Abstract: Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention relates to a method of preparing 2-alkylcysteine comprising condensing cysteine with an aryl nitrile to form a 2-arylthiazoline-4-carboxylic acid, forming a 2-arylthiazoline-4-amide using an amine group comprising at least one substituted or unsubstituted alkyl group that comprises one or more chiral carbon atoms, and alkylating at the 4-position of the thiazoline ring to form a 2-aryl-4-alkyl-thiazoline-4-amide. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In one embodiment, an aryl nitrile or imidate is condensed with cysteine or a 2-alkyl cysteine.Type: GrantFiled: May 15, 2003Date of Patent: September 21, 2004Assignee: Genzyme CorporationInventors: Rayomand H. Gimi, Mukund S. Chorghade, Sunil V. Mhaskar
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Publication number: 20040082796Abstract: A useful and efficient method of preparing an alkylated thiazoline carboxylic acid, or a derivative thereof, comprises coupling a substituted aryl nitrile such as, for example, 2,4-dimethoxybenzonitrile or 4-methoxybenzonitrile, with a cysteine ester to form a substituted thiazoline carboxylic acid ester; optionally hydrolyzing the substituted thiazoline carboxylic acid ester to form a substituted thiazoline carboxylic acid; optionally, protecting the carboxyl group; alkylating the thiazoline ring at the 4-carbon position, as indicated in Structural Formula (I), with a compound of the formula R1—L, wherein R1 is as defined above and L is a leaving group, in the presence of a phase transfer catalyst; and, optionally, deprotecting the carboxyl group.Type: ApplicationFiled: May 15, 2003Publication date: April 29, 2004Applicant: Genzyme CorporationInventors: Mukund S. Chorghade, Rayomand H. Gimi, Peter D. McDonnell, Paul Wolstenholme-Hogg
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Publication number: 20030236435Abstract: Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention relates to a method of preparing a 2-alkylcysteine comprising condensing cysteine with an aryl nitrile to form a 2-arylthiazoline-4-carboxylic acid, esterifying the 2-arylthiazoline-4-carboxylic acid using a substituted or unsubstituted alcohol group comprising one or more chiral carbons, and alkylating at the 4-position of the thiazoline ring to form a 2-aryl-4-alkyl-thiazoline-4-carboxylic acid ester. The chiral templates present in the thiazoline carboxylic acid ester can provide face selectivity, and consequently desired stereochemistry, during the delivery of an alkyl group to the 4-position of the thiazoline ring. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring.Type: ApplicationFiled: May 15, 2003Publication date: December 25, 2003Applicant: Genzyme CorporationInventors: Rayomand H. Gimi, Mukund S. Chorghade, Sunil V. Mhaskar
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Publication number: 20030236404Abstract: Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention provides methods of preparing 2-alkylcysteine derivatives. In another embodiment, the method comprises forming a 2-alkylcysteine derivative from a cysteine derivative in the presence of a phase transfer catalyst. In particular, the present invention provides methods for preparing 2-methylcysteine derivatives.Type: ApplicationFiled: May 15, 2003Publication date: December 25, 2003Applicant: Genzyme CorporationInventors: Rayomand H. Gimi, Mukund S. Chorghade
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Publication number: 20030236434Abstract: Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. In one embodiment, the present invention relates to a method of preparing 2-alkylcysteine comprising condensing cysteine with an aryl nitrile to form a 2-arylthiazoline-4-carboxylic acid, forming a 2-arylthiazoline-4-amide using an amine group comprising at least one substituted or unsubstituted alkyl group that comprises one or more chiral carbon atoms, and alkylating at the 4-position of the thiazoline ring to form a 2-aryl-4-alkyl-thiazoline-4-amide. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In one embodiment, an aryl nitrile or imidate is condensed with cysteine or a 2-alkyl cysteine.Type: ApplicationFiled: May 15, 2003Publication date: December 25, 2003Applicant: Genzyme CorporationInventors: Rayomand H. Gimi, Mukund S. Chorghade, Sunil V. Mhaskar