Abstract: An applicator can have an ampoule body for holding a medical liquid; a tab extending away from the ampoule body and being twistable or deflectable with respect to a longitudinal axis of the ampoule body; and a frangible region in between the tab and the distal portion of the ampoule body, the frangible region being breakable in response to twisting or deflection of the tab. The applicator can have a resilient structure extending between the tab and the ampoule body and configured to allow the twisting or deflection to enable breakage of the frangible region while remaining intact and providing axial rigidity in response to a deflection pressure exerted on the tab during application of the medical liquid. The applicator can have features such as a thumb rest, a bubble portions, a pyramidal body construction, an offset frangible nodule, and various tab and head constructions.

Abstract: A liquid dispensing applicator that can include a sound-generating system for generating a sound during rotation of the container body to indicate to a user that the rotation is performed. The sound-generating system includes at least one knob and a plurality of ribs. The at least one knob cooperates with at least some of the ribs during rotation of the container body, in order to generate the sound. The liquid dispensing applicator can alternatively or also include a wing element insertable into a slot provided in an absorbent material. The wing element extends from an outer surface of the head component and comprises opposing surfaces and a at least one edge spike provided on an edge of the at least one wing element, and configured to prevent the absorbent material from being removed after insertion of the wing element into the slot.

Abstract: Techniques for sterilizing chlorhexidine based antiseptic formulations include exposing a sealed container containing the formulation to heat at a temperature and heating time sufficient to sterilize the chlorhexidine based antiseptic formulation and the hermetically sealed interior of the container, which may be an applicator, a bottle, a swab stick, or a pad-containing pouch.

Abstract: There is provided a liquid dispensing applicator. The liquid dispensing applicator can include a sound-generating system for generating a sound during rotation of the container body to indicate to a user that the rotation is performed. The sound-generating system includes at least one knob and a plurality of ribs. the at least one knob cooperates with at least some of the ribs during rotation of the container body, in order to generate the sound. The liquid dispensing applicator can alternatively or also include a wing element insertable into a slot provided in an absorbent material. The wing element extends from an outer surface of the head component and comprises opposing surfaces and a at least one edge spike provided on an edge of the at least one wing element, and configured to prevent the absorbent material from being removed after insertion of the wing element into the slot.

Abstract: A liquid dispensing applicator can include a container body containing a liquid and having an end with a projection; a head component cooperating with the container body and having a slot for receiving the projection; the container body and the head component being rotatable with respect to each other to enable engagement of the projection and the slot and cause breakage of the projection allowing the liquid to flow from the container body into the head component; and a radial locking system for radially locking the container body and the head component together after rotation with respect to each other. The radial locking system can include a lip-and-channel system where the lip radially slides within the channel and is retained at a far end in a fluid application position.

Abstract: A liquid dispensing applicator has a container body holding liquid, a longitudinal axis for rotation and an offset projection located to avoid traversing the longitudinal axis. The applicator also has a head component receiving an end of the container body and has a slot system for receiving the offset projection. The container body and the head component are rotatable with respect to each other to cause the offset projection and the slot system to engage and break the offset projection, allowing liquid release through the head for application. The applicator may have an axial locking system and a radial locking system for locking the container body and the head component together at various positions for improved stability, alignment or reliability.

Abstract: A liquid dispensing applicator can include a container body containing a liquid and having an end with a projection; a head component cooperating with the container body and having a slot for receiving the projection; the container body and the head component being rotatable with respect to each other to enable engagement of the projection and the slot and cause breakage of the projection allowing the liquid to flow from the container body into the head component; and a radial locking system for radially locking the container body and the head component together after rotation with respect to each other. The radial locking system can include a lip-and-channel system where the lip radially slides within the channel and is retained at a far end in a fluid application position.

Abstract: Techniques for sterilizing chlorhexidine based antiseptic formulations include exposing a sealed container containing the formulation to heat at a temperature and heating time sufficient to sterilize the chlorhexidine based antiseptic formulation and the hermetically sealed interior of the container, which may be an applicator, a bottle, a swab stick, or a pad-containing pouch.

Abstract: A liquid dispensing applicator has a container body holding liquid, a longitudinal axis for rotation and an offset projection located to avoid traversing the longitudinal axis. The applicator also has a head component receiving an end of the container body and has a slot system for receiving the offset projection. The container body and the head component are rotatable with respect to each other to cause the offset projection and the slot system to engage and break the offset projection, allowing liquid release through the head for application. The applicator may have an axial locking system and a radial locking system for locking the container body and the head component together at various positions for improved stability, alignment or reliability.