Abstract: Systems and methods for immersion imaging of a flowcell. In one example, an imaging system includes liquid ports in leading and trailing positions relative to a scanned imaging objective. The leading liquid port dispenses an immersion liquid into a space between the distal end of the imaging objective and the flowcell's cover, with the trailing liquid port collecting the immersion liquid. In another example, an imaging system includes a flowcell with a cover that is moveable relative a substrate. The system is configured to move the imaging objective and flowcell cover as a unit relative to the flowcell substrate.

Abstract: A biochemical substance analysis system is used to detect biological characteristics of a sample in a flow cell, and includes a detection system, a scheduling system, a biochemical reaction system, and a control system. The scheduling system is used to schedule the flow cell at different sites, including sites in the detection system and sites in the biochemical reaction system. The biochemical reaction system is used to allow the sample to react in the flow cell. The detection system is used to detect a signal from the reacted sample to obtain a signal representing the biological characteristics of the sample. The control system is used to control the detection system, the scheduling system, and the biochemical reaction system to cooperate. The present disclosure improves the automation degree and flux of the biochemical substance analysis.

Abstract: A biochemical substance analysis system (5) is used to detect biological characteristics of a sample in a flow cell (38), and includes a detection system (51), a scheduling system (53), a biochemical reaction system (55), and a control system (57). The scheduling system (53) is used to schedule the flow cell (38) at different sites, including sites in the detection system (51) and sites in the biochemical reaction system (55). The biochemical reaction system (55) is used to allow the sample to react in the flow cell (38). The detection system (51) is used to detect a signal from the reacted sample to obtain a signal representing the biological characteristics of the sample. The control system (57) is used to control the detection system (51), the scheduling system (53), and the biochemical reaction system (55) to cooperate. The disclosure improves automation degree and flux of the biochemical substance analysis.

Abstract: Systems and methods for immersion imaging of a flowcell. In one example, an imaging system includes liquid ports in leading and trailing positions relative to a scanned imaging objective. The leading liquid port dispenses an immersion liquid into a space between the distal end of the imaging objective and the flowcell's cover, with the trailing liquid port collecting the immersion liquid. In another example, an imaging system includes a flowcell with a cover that is moveable relative a substrate. The system is configured to move the imaging objective and flowcell cover as a unit relative to the flowcell substrate.

Abstract: A nucleic acid sequencing system may include non-planar substrates coupled to the outer surface of a rotating drum. The substrates may be curved and include a plurality of nucleic acid samples. A detection system, including for example an objective and a camera, may detect sequencing events on the non-planar substrate while the non-planar substrate is rotated relative to the detection system around a longitudinal axis of the drum by the actuation system.

Abstract: Double sided flow cell and other substrate imaging systems, such as imaging systems used in nucleic acid sequencing and similar processes. In one example, the imaging system includes a flipper to facilitate imaging different surfaces of the flow cell or other substrate. In another example, the imaging system includes two optical systems for imaging different surfaces of the flow cell or other substrate. In another example, the imaging system is an immersion system. In these and other examples, the system may include an auto-focus sub-system configured to accurately focus the optics on one surface of the double sided flow cell without interference from the other surface of the flow cell.

Abstract: A nucleic acid sequencing system may include a substrate coupled to a rotating disk. The substrate may include a plurality of nucleic acid samples. A detection system, including for example an objective and a camera, may detect sequencing events on the substrate while the substrate is rotated relative to the detection system around a rotational axis of the substrate, perpendicular to a surface of the substrate, by the actuation system.

Abstract: A biochemical substance analysis system (5) is used to detect biological characteristics of a sample in a flow cell (38), and includes a detection system (51), a scheduling system (53), a biochemical reaction system (55). and a control system (57). The scheduling system (53) is used to schedule the flow cell (38) at different sites, including sites in the detection system (51) and sites in the biochemical reaction system (55). The biochemical reaction system (55) is used to allow the sample to react in the flow cell (38). The detection system (51) is used to detect a signal from the reacted sample to obtain a signal representing the biological characteristics of the sample. The control system (57) is used to control the detection system (51), the scheduling system (53), and the biochemical reaction system (55) to cooperate. The disclosure improves automation degree and flux of the biochemical substance analysis.