Patents by Inventor Razvan Miclea

Razvan Miclea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions of Less Immunogenic and Long-Circulating Protein-Lipid Complexes
    Publication number: 20110123625
    Abstract: Provided are lipidic particles comprising phosphatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In these compositions, the therapeutic agents have reduced immunogenicity and/or longer circulating time. These compositions can be used for therapeutic administration of the peptides, polypeptides and/or proteins.
    Type: Application
    Filed: December 28, 2010
    Publication date: May 26, 2011
    Inventors: Sathy V. Balu-Iyer, Robert M. Straubinger, Razvan Miclea, Aaron Peng
  • Compositions of less immunogenic and long-circulating protein-lipid complexes
    Patent number: 7875289
    Abstract: Provided are lipidic particles comprising phosphatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In these compositions, the therapeutic agents have reduced immunogenicity and/or longer circulating time. These compositions can be used for therapeutic administration of the peptides, polypeptides and/or proteins.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: January 25, 2011
    Assignee: The Research Foundation of State University of New York
    Inventors: Sathy V. Balu-Iyer, Robert M. Straubinger, Razvan Miclea, Aaron Peng
  • Method for treating blood coagulation disorders
    Patent number: 7875288
    Abstract: Provided is a method for treatment of blood coagulation disorders. The method comprises administering to an individual compositions comprising lipidic particles comprising phosphatidylcholine, phosphatidylinositol and cholesterol. One or more peptides, polypeptides or proteins involved in the blood coagulation cascade are associated with the lipidic particles.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: January 25, 2011
    Assignee: The Research Foundation of State University of New York
    Inventors: Sathy V. Balu-Iyer, Robert M. Straubinger, Razvan Miclea, Aaron Peng
  • Method for treating blood coagulation disorders
    Publication number: 20070275050
    Abstract: Provided is a method for treatment of blood coagulation disorders. The method comprises administering to an individual compositions comprising lipidic particles comprising phopatidylcholine, phosphatidylinositol and cholesterol. One or more peptides, polypeptides or proteins involved in the blood coagulation cascade are associated with the lipidic particles.
    Type: Application
    Filed: March 30, 2007
    Publication date: November 29, 2007
    Inventors: Sathy Balu-Iyer, Robert Straubinger, Razvan Miclea, Aaron Peng
  • Compositions of less immunogenic and long-circulating protein-lipid complexes
    Publication number: 20070274980
    Abstract: Provided are lipidic particles comprising phopatidylcholine, phosphatidylinositol and cholesterol. Also provided are compositions comprising the lipidic particles and having associated therewith therapeutic agents such as peptides, polypeptides or proteins. In these compositions, the therapeutic agents have reduced immunogenicity and/or longer circulating time. These compositions can be used for therapeutic administration of the peptides, polypeptides and/or proteins.
    Type: Application
    Filed: March 30, 2007
    Publication date: November 29, 2007
    Inventors: Sathy Balu-Iyer, Robert Straubinger, Razvan Miclea, Aaron Peng
  • Compositions and methods for less immunogenic protein-lipid complexes
    Publication number: 20070141135
    Abstract: The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phospatidyl ethanolamine.
    Type: Application
    Filed: June 29, 2006
    Publication date: June 21, 2007
    Inventors: Sathy Balu-lyer, Robert Straubinger, Karthik Ramani, Razvan Miclea