Patents by Inventor Razvan Nutiu

Razvan Nutiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamer selection method
    Patent number: 7745607
    Abstract: The present invention provides a method for the selection of aptamer sequences and aptamers identified using the method. The method comprises immobilizing a library oligonucleotide by forming a duplex with an antisense oligonucleotide, reating the duplex molecule with a target and collecting oligonucleotide molecules which dissociate from the duplex structure.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: June 29, 2010
    Assignee: McMaster University
    Inventors: Yingfu Li, Razvan Nutiu
  • Aptamer Selection Method
    Publication number: 20070243529
    Abstract: The present invention provides a method for the selection of aptamer sequences and aptamers identified using the method. The method comprises immobilizing a library oligonucleotide by forming a duplex with an antisense oligonucleotide, reating the duplex molecule with a target and collecting oligonucleotide molecules which dissociate from the duplex structure.
    Type: Application
    Filed: March 31, 2004
    Publication date: October 18, 2007
    Inventors: Yingfu Li, Razvan Nutiu
  • Method for monitoring reactions in real time
    Publication number: 20060275854
    Abstract: Methods for monitoring chemical reactions in real time are provided. The methods involve the use of a signaling aptamer that has a different affinity for the substrate and the product of the chemical reaction. The conversion from substrate to product is detected a change in signal, in particular a change in fluorescent signal. The methods of the present invention are also useful to measure enzyme activity and to screen for enzyme inhibitors.
    Type: Application
    Filed: June 29, 2004
    Publication date: December 7, 2006
    Inventors: Yingfu Li, Razvan Nutiu
  • Method of immobilizing nucleic acid aptamers
    Publication number: 20060068407
    Abstract: The present invention relates to methods of immobilizing nucleic acid aptamers within a sol-gel matrix. The aptamer system remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate.
    Type: Application
    Filed: February 22, 2005
    Publication date: March 30, 2006
    Applicant: McMaster University
    Inventors: Nicholas Rupcich, Razvan Nutiu, John Brennan, Yingfu Li
  • Tripartite molecular beacons
    Publication number: 20040086879
    Abstract: Tripartite molecular beacons (TMBs), are disclosed that are readily adaptable to high throughput applications. Each tripartite molecular beacon comprises three oligonucleotide components. The first oligonucleotide forms a hairpin stem and loop structure and the second and third oligonucleotides each comprise a sequence complementary to opposite strands of the hairpin stem. The second oligonucleotide has a fluorophore attached thereto and the third oligonucleotide has a quencher attached thereto.
    Type: Application
    Filed: December 19, 2002
    Publication date: May 6, 2004
    Inventors: Yingufu Li, Razvan Nutiu