Abstract: A method of operating a waste collection unit including a light assembly separate from a display panel. A vacuum level of the vacuum drawn on a waste canister is measured with a vacuum sensor. The light assembly positioned adjacent a manifold receiver is operated to selectively emit light of a color based on the measured vacuum level. A commanded vacuum level may be received on the display panel, and a colored image indicative of a commanded vacuum level may be displayed on the display panel. The waste collection unit may include plural manifold receivers each configured to receive a manifold. The light assembly that is adjacent the manifold receiver corresponding to the waste canister into which the vacuum is being drawn may be operated to selectively emit light to emit light at different colors or different patterns based on the operating state of the waste collection unit.

Abstract: An autonomous medical waste collection assembly. A base supports a waste canister in fluid communication with a manifold receiver, and a suction pump. A controller is in electronic communication with a powered wheel and configured to transmit a movement signal for a motor to power the powered wheel to move the assembly along a floor surface. The assembly may be operable in an autonomous mode in which the powered wheel automatically moves the assembly along the floor surface, and a manual mode in which resistance from the powered wheel is negated to provide for manual movement of the assembly. The controller may be further configured to steer the assembly based on a current location input signal, and a disposal location input signal from a locator network within the medical facility that is indicative of a location of a disposal station.

Abstract: A system for the detection of money laundering activities involving casino slot machines and Video Lottery Terminals (collectively “VLTs/Slot Machines”) using an executable copy of security software installed individually at each participating VLT/Slot Machine. The security software monitors cash in/plays/and cash out on all connected VLTs/Slot Machines. The security software contains an artificial intelligence module that flags “suspicious activity” at all connected VLTs/Slot Machines and keeps an audit trail. The security software will disable/track TITO serial numbers/barcodes of all TITOs printed from VLTs in “silent alarm mode”. TITO serial numbers/barcodes printed in “alarm mode” need to be redeemed at the cashier's cage and will not work in an automated redemption kiosk or Ticket Redemption Unit, and the cashiers are forewarned to require positive identification and complete a Suspicious Activity Report (SARC).

Abstract: A frangible manifold is used in connection with flight termination operations and stage separation. The manifold has a first portion and a second portion separated by a frangible portion. An aperture extends through the first, second and third sections. A first ordnance termination line is positioned in at least the first section of the first portion of the manifold. A second ordnance termination line is positioned in at least the second section of the second portion of the manifold. In the event of a flight termination, detonation of one ordnance line causes detonation of the second ordnance line. In the event of stage separation, the manifold splits at the frangible portion and the two ordnance lines are safely separated.

Abstract: A method for designing a uni-compartmental orthopaedic prosthesis includes generating a three-dimensional statistical model of a knee joint, determining a curvature of a section of a bone of the knee joint represented by the three-dimensional statistical model, and designing a section of the uni-compartmental orthopaedic prosthesis corresponding to the section of the bone of the knee joint to have a curvature that matches the curvature of the section of the bone of the knee joint. Additionally, a tibial and femoral uni-compartmental orthopaedic prosthesis are also disclosed, each of which includes a section having a curvature that matches a corresponding section of a corresponding bone of the knee joint represented by the three-dimensional statistical model.

Abstract: A waste collection system for collecting medical waste. A mobile rover includes at least one waste container, and a rover controller. A chassis is removably couplable with the mobile rover and includes a vacuum regulator, and a chassis controller. The chassis controller is configured to control operation of the vacuum regulator based on a pressure signal from a pressure sensor disposed on the mobile rover. The chassis may include a control panel configured to receive an input of and display a vacuum level, and the chassis controller may control operation of the vacuum regulator based on the input. The mobile rover may include plural waste containers, and the chassis may include plural vacuum regulators. The chassis controller may control operation of the vacuum regulators on the chassis to independently regulate the vacuum level supplied to each of the waste containers on the mobile rover.

Abstract: A method of making a vegetable- and/or fruit-containing snack food is described. The snack food includes a rigid starch matrix that contains potato starch and a plurality of individual pieces of vegetable and/or fruit randomly distributed throughout the matrix. At least 50% by number of the pieces have a minimum dimension of at least 0.75 mm and a maximum dimension of up to 7 mm. The matrix includes a first cellular structure of first cellular pores having a first pore size distribution and the pieces include a second cellular structure of second cellular pores having a second pore size distribution. At least some of the second cellular pores are defined by polysaccharide cell walls of the respective vegetable and/or fruit. The first pore size distribution has a larger number-average pore size and a wider distribution than the second pore size distribution.

Abstract: A system is provided comprising a robotic instrument for use with a tool. In some versions, the robotic instrument comprises a hand-held portion to be held by a user and a tool support movably coupled to the hand-held portion to support the tool. A plurality of actuators operatively interconnect the tool support and the hand-held portion to move the tool support in three degrees of freedom relative to the hand-held portion. An optional constraint assembly may operatively interconnect the tool support and the hand-held portion to constrain movement of the tool support relative to the hand-held portion in three degrees of freedom. A guidance array assists users in positioning the tool and/or portions of the instrument.

Abstract: A cassette for collecting a tissue sample. The cassette includes a housing configured to be removably coupled with a manifold receiver of a medical fluid collection system. The housing defines a first void space, a second void space, and an outlet opening. A catch tray is removably positionable within the first void space and includes a screen defining porous features for collecting the tissue sample. A filter element separate from the catch tray is disposed within the second void space. The housing may include a cap portion defining the first void space, and a shell portion coupled to the cap portion and defining the second void space. The cassette may be simultaneously operable in a tissue collection mode in which fluid is suctioned across the catch tray to collect the tissue sample, and a bypass mode in which the fluid is not suctioned across the catch tray.

Abstract: The invention is directed to Anti-LILRB1 and anti-LILRB2 bispecific antibodies, anti-LILRB1 antibodies, and anti-LILRB2 antibodies, their uses and pharmaceutical compositions thereof.

Abstract: There is provided a method for inspecting and measuring one or more installed one-sided fasteners in a structure. The method includes positioning an X-ray imaging system at a first side of the structure at a location of the one or more installed one-sided fasteners. The method further includes emitting X-rays at the first side of the structure, detecting backscatter from the one or more installed one-sided fasteners, and generating image data from the X-ray imaging system in response to detecting the backscatter. The method further includes measuring and analyzing the image data, with an image processing system, to obtain one or more measurements of one or more dimensions of the one or more installed one-sided fasteners. The method further includes using the image data to inspect the one or more installed one-sided fasteners, and to detect any inconsistencies in the one or more measurements of the one or more dimensions.

Abstract: The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.

Abstract: A cassette for collecting a tissue sample. The cassette includes a housing configured to be removably coupled with a manifold receiver of a medical fluid collection system. The housing defines a first void space, a second void space, and an outlet opening. A catch tray is removably positionable within the first void space and includes a screen defining porous features for collecting the tissue sample. A filter element separate from the catch tray is disposed within the second void space. The housing may include a cap portion defining the first void space, and a shell portion coupled to the cap portion and defining the second void space. The cassette may be simultaneously operable in a tissue collection mode in which fluid is suctioned across the catch tray to collect the tissue sample, and a bypass mode in which the fluid is not suctioned across the catch tray.

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to bone morphogenetic protein-9 (BMP9) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

Abstract: A method of method of manufacturing a surgical waste collection manifold with a volume collected datum and a rover type to ensure compatibility with a surgical waste collection rover is provided. The surgical waste collection rover including a vacuum pump and a receiver defining an opening. The method includes obtaining a second manifold. The second manifold having a second housing defining a surface, the housing defining a second manifold volume and a second outlet opening in fluid communication with the second manifold volume. The method may further include coupling a second circuit to the surface of the second manifold, the second circuit comprising a second memory device including a third memory bank and a fourth memory bank, the third memory bank including a fifth memory field and the fourth memory bank including a sixth memory field.

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to E-selectin. The invention includes uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

Abstract: The disclosed compositions, methods, and systems are useful in treating and preventing various cancers associated with buildup of mitochondrial cholesterol. In many embodiments, the disclosed compositions, methods, and systems may improve the efficacy and cytotoxicity of chemotherapeutic compounds, for example increasing cellular sensitivity to chemotherapy and/or reducing or preventing resistance. In many embodiments, the cancer may be early or late stage hepatocellular carcinoma.

Abstract: The present invention discloses an isolated antibody that specifically binds to TL1A, comprising a heavy chain variable region (TL1A-VH) and a light chain variable region (TL1A-VL), comprising the CDR-H1, CDR-H2, and CDR-H3 sequences of a TL1A-VH sequence selected from the group consisting of SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 47, SEQ ID NO: 49, SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 57, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 78, SEQ ID NO: 80, SEQ ID NO: 89, SEQ ID NO: 93, SEQ ID NO: 95, SEQ ID NO: 97, SEQ ID NO: 99, SEQ ID NO: 101, SEQ ID NO: 103, SEQ ID NO: 105, SEQ ID NO: 110, SEQ ID NO: 120; and the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 18.

Abstract: Disclosed herein are compositions, methods, and systems for enhancing cholesterol degradation in a cell, tissue, or organism. In many embodiments, the disclosure describes the use of one or more proteins, or sequences coding therefor, to enhance flow of cholesterol into the mitochondrion, where the cholesterol is degraded by one or more proteins comprising bacteria-related sequences. The compositions, methods, and systems disclosed herein are useful in the prevention or treatment of diseases, disorders, and conditions associated with high levels of cholesterol in the blood or cells of a patient.

Abstract: The present invention relates to antibodies that specifically bind to B7-H4 (B7 Homology 4, encoded by gene VTCN1) and bispecific antibodies that specifically bind to both B7-H4 and CD3 (Cluster of Differentiation 3), and polynucleotides, pharmaceutical compositions and methods and uses thereof.