Abstract: System and method for control area visualization according to certain embodiments. For example, a method includes: receiving object data from a plurality of data sources; identifying a plurality of first objects associated with a first group based at least in part on the object data, each first object of the plurality of first objects being associated with a geospatial location and a buffer area; determining a first control area associated with the first group based at least in part on the geospatial location and the buffer area of each first object of the plurality of first objects; and causing a presentation of the first control area on a display.

Abstract: Methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain are provided. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.

Abstract: The present disclosure relates to compounds suitable for the inhibition of protein arginine methyl-transferase (PRMT), in particular PRMT5. These compounds may be for use as therapeutic agents, in particular, agents for use in the treatment and/or prevention of proliferative diseases, such as cancer.

Abstract: Geographic identifiers and television network affiliate data may be received. A primary local affiliate station for each of the plurality of national television networks may be determined for each geographic identifier. The geographic identifiers that have the same primary local affiliate for each of the plurality of national television networks may be grouped together to form a first plurality of markets. The markets from the first plurality of markets that have the same primary local affiliate for a first subset of the plurality of national television networks may be merged together, resulting in a second, smaller plurality of markets. Each of the geographic identifiers may be assigned to a market from the second plurality of markets, and a report indicating the second plurality of markets may be output.

Abstract: The present invention relates to compounds of Formula (I) as defined herein, and salts, hydrates and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to the use of compounds of Formula (I) in the treatment or prevention of PRMT5-mediated disorders, such as cancer.

Abstract: The present disclosure relates to compounds suitable for the inhibition of protein arginine methyl-transferase (PRMT), in particular PRMT5. These compounds may be for use as therapeutic agents, in particular, agents for use in the treatment and/or prevention of proliferative diseases, such as cancer.

Abstract: The present invention relates to compounds of Formula (I) as defined herein, and salts, hydrates and solvates thereof. The present invention also relates to pharmaceutical compositions comprising compounds of Formula (I), and to the use of compounds of Formula (I) in the treatment or prevention of PRMT5-mediated disorders, such as cancer.

Abstract: A reversible mesh garment to prevent mosquito bites and increase safety through greater visibility of the wearer in dark conditions includes a tubular sleeve formed from mesh fabric, the tubular sleeve having a first end and a second end; first and second adjustable elastic bands housed in a woven fabric casing at each end of the tubular sleeve, wherein the first elastic band spans the perimeter circumference of the first end of the tubular sleeve and the second elastic band spans the perimeter circumference of the second end of the tubular sleeve so as to secure the garment to the wearer's legs from groin to ankle; an LED light source; and an additional layer of a strip of mesh fabric two inches wide is sewn as the top outer layer at the side seams thereby forming a mesh channel housing the LED light source.

Abstract: A reversible mesh garment to prevent mosquito bites and increase safety through greater visibility of the wearer in dark conditions includes a tubular sleeve formed from mesh fabric, the tubular sleeve having a first end and a second end; first and second adjustable elastic bands housed in a woven fabric casing at each end of the tubular sleeve, wherein the first elastic band spans the perimeter circumference of the first end of the tubular sleeve and the second elastic band spans the perimeter circumference of the second end of the tubular sleeve so as to secure the garment to the wearer's legs from groin to ankle; an LED light source; and an additional layer of a strip of mesh fabric two inches wide is sewn as the top outer layer at the side seams thereby forming a mesh channel housing the LED light source.

Abstract: Compositions for topical use and having a melanin synthesis-inhibiting activity that include an amount of a botanical extract of at least one of Aspalathus Linearis, Matricaria, Saxifraga, Astragalus, Taraxacum officinale/mongolicum, Ferula varia/foetida, Carthamus tinctorius, Sophora flavescentis, or Chrysanthemum morifolium effective to reduce melanin synthesis are described. Methods for inhibiting melanin synthesis and for skin whitening are also described.

Abstract: A protective sleeve-like garment for the legs made of a mesh fabric in a tubular shape with an adjustable elastic band at groin level and another non-rolling elastic band at the ankle, both encased in a woven fabric for comfort. Its dual core purpose is to create a chemical-free barrier between the skin of the wearer's legs and mosquitoes and provide a safety feature of added visibility of the wearer when outdoors, dusk to dark, with the use of light-reflective safety ribbon down the full length of the outer seam of the garment making the wearer more visible to oncoming cars and those searching with flashlights for the wearer. These instances are most significant for children as the wearer of the garment while at play in the evening, camping and hiking.

Abstract: Compositions for topical use and having a melanin synthesis-inhibiting activity that include an amount of a botanical extract of at least one of Aspalathus Linearis, Matricaria, Saxifraga, Astragalus, Taraxacum officinale/mongolicum, Ferula varia/foetida, Carthamus tinctorius, Sophora flavescentis, or Chrysanthemum morifolium effective to reduce melanin synthesis are described. Methods for inhibiting melanin synthesis and for skin whitening are also described.

Abstract: Systems and methods for previewing beauty cosmetic application through an integrated application of an electronic device such as, but not limited to, a smartphone or tablet computer.

Abstract: Methods of paying user bills on behalf of a user are described. In one embodiment, the method includes receiving from a vendor a user bill having a user identifier, a vendor identifier, and a bill amount. The method further includes obtaining the user identifier, the vendor identifier, and the bill amount, associating the bill with the user based on the user identifier, and associating the bill with the vendor based on the vendor identifier. The method further includes determining whether the bill is payable, which includes comparing the bill to stored bill data associated with the user and the vendor. When the bill is payable, the method further includes obtaining funds from an account of the user, dispersing funds to the vendor to pay the bill and storing an indication of the paying of the bill.

Abstract: Methods of paying user bills on behalf of a user are described. In one embodiment, the method includes receiving from a vendor a user bill having a user identifier, a vendor identifier, and a bill amount. The method further includes obtaining the user identifier, the vendor identifier, and the bill amount, associating the bill with the user based on the user identifier, and associating the bill with the vendor based on the vendor identifier. The method further includes determining whether the bill is payable, which includes comparing the bill to stored bill data associated with the user and the vendor. When the bill is payable, the method further includes obtaining funds from an account of the user, dispersing funds to the vendor to pay the bill and storing an indication of the paying of the bill.

Abstract: Apparatus (10) is provided for measurement of the toughness of edible products such as breads and cheeses. The apparatus (10) preferably includes a texture analyzer (12) equipped with a load cell crossarm (18); a special sample holding device (14) is mounted on the analyzer (12) and includes a base (30) adapted to hold a sample (88) and equipped with a flexible elongated pull wire (34). A cover assembly (32) is positioned atop the sample (88) and includes retention pins (64-70) to hold the sample in a substantially stationary condition. In use, the pull wire (34) is coupled to crossarm (18) and the analyzer (12) is actuated to elevate the arm (18), thus pulling the wire (34) at least partially through the sample (88). The force required to pull the wire (34) through the sample (88) is taken as a measure of sample toughness.

Abstract: A new and unique variety of brown mushroom is described. It exhibits (1) high production yields when compared to common commercial varieties, (2) excellent Verticillium disease resistance and (3) a distinct electrophoretic isozyme pattern.