Abstract: The present disclosure provides a method for of determining the level of circulating tumor cells (CTCs) in a sample having blood cells from a patient comprising obtaining a test sample from a human subject; enriching circulating tumor cells (CTC); hybridizing the enriched cells in the sample with labeled nucleic acid probes that hybridize to regions of chromosomal DNA; evaluating the signal pattern for the selected cells by detecting fluorescence in situ hybridization from cells; detecting CTCs based on the pattern of hybridization to the labeled nucleic acid probes to said selected cells; and identifying the subject at risk for the development of lung cancer when the number of CTC per sample is above a predetermined cutoff value.

Abstract: A computing device comprises a base that comprises a base surface configured to support the computing device on a supporting surface, and a front wall adjoining and extending away from the base surface. The computing device also includes a chassis adjoining the base, the chassis comprising a planar user interactive surface comprising one or more user input components. The chassis also comprises an overhanging brim that extends beyond at least the front wall of the base and comprises at least one magnet configured to removably retain a stylus underneath the overhanging brim.

Abstract: A computing device comprises a base that comprises a base surface configured to support the computing device on a supporting surface, and a front wall adjoining and extending away from the base surface. The computing device also includes a chassis adjoining the base, the chassis comprising a planar user interactive surface comprising one or more user input components. The chassis also comprises an overhanging brim that extends beyond at least the front wall of the base and comprises at least one magnet configured to removably retain a stylus underneath the overhanging brim.

Abstract: In some embodiments, a non-transitory processor-readable medium stores code representing instructions to be executed by a processor. The code includes code to cause the processor to receive a plurality of sets of images associated with a sample treated with fluorescence in situ hybridization (FISH) probes. Each image from that set of images is associated with a different focal length using a fluorescence microscope. Each FISH probe can selectively bind to a unique location on chromosomal DNA in the sample. The code further causes the processor to identify cell nuclei in the images. The code further causes the processor to apply a convolutional neural network (CNN) to each set of images. The CNN is configured to identify a probe indication from a plurality of probe indications for that set of images. The code further causes the processor to identify the sample as containing circulating tumor cells.

Abstract: A hinge system has a first body and a second body rotatably connected to one another around a first pivot point. The second body has a top surface and bottom surface positioned opposite one another in a vertical direction of the second body. A translation mechanism is connected to the second body and the first pivot point to displace the first pivot point in the vertical direction relative to the second body.

Abstract: A method of selectively illuminating part of an electronic device includes obtaining a posture status of a hinge supporting a display cover relative to a base of the electronic device and illuminating an optical module positioned on an outer surface of the electronic device based on the hinge position of the posture status.

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Abstract: The patent relates to securely storing an input device relative to a computing device. One example can include a housing and a trough defined in the housing and configured to receive at least a portion of an input device. This example can also include a pair of opposing levers that are contained in the trough when the trough is empty and that pivot proud out of the trough around and against the input device installed in the trough.

Abstract: The patent relates to securely storing an input device relative to a computing device. One example can include a housing and a trough defined in the housing and configured to receive at least a portion of an input device. This example can also include a pair of opposing levers that are contained in the trough when the trough is empty and that pivot proud out of the trough around and against the input device installed in the trough.

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Abstract: A display positioning assembly comprises a base portion and a display portion. The base portion comprises a base ferromagnetic component moveably retained within the base portion. The display portion comprises a display ferromagnetic component. The display portion is moveably coupled to the base portion. One or both of the base ferromagnetic component and display ferromagnetic component is a magnet.

Abstract: A display positioning assembly comprises a base portion and a display portion. The base portion comprises a base ferromagnetic component moveably retained within the base portion. The display portion comprises a display ferromagnetic component. The display portion is moveably coupled to the base portion. One or both of the base ferromagnetic component and display ferromagnetic component is a magnet.

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Abstract: A computing device includes a housing having an inner surface, a first outer surface, a second outer surface, and a side extending between the first outer surface and the second outer surface. The computing device also includes a heat generating electronic device, a first heat spreader, and a second heat spreader. At least a portion of the first heat spreader abuts or is adjacent to the inner surface of the housing. The second heat spreader extends from a first position within the housing, at or adjacent to the heat generating electronic device to a second position within the housing. The second position is closer to the side of the housing than the first position. A first portion of the second heat spreader abuts the first heat spreader, and a second portion of the second heat spreader is at a distance from the first heat spreader.

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Abstract: A computing device includes a housing having an inner surface, a first outer surface, a second outer surface, and a side extending between the first outer surface and the second outer surface. The computing device also includes a heat generating electronic device, a first heat spreader, and a second heat spreader. At least a portion of the first heat spreader abuts or is adjacent to the inner surface of the housing. The second heat spreader extends from a first position within the housing, at or adjacent to the heat generating electronic device to a second position within the housing. The second position is closer to the side of the housing than the first position. A first portion of the second heat spreader abuts the first heat spreader, and a second portion of the second heat spreader is at a distance from the first heat spreader.

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

Abstract: The description relates to devices, such as computing devices having displays that can be rotated through a range of travel. In some cases, a display can be readily adjusted to a desired physical location. The device can counter-balance the display to create a near weightless feel for the user when repositioning the display.