Abstract: A dental drill system with electrical-impedance sensing indicates when a bit of the drill system approaches cortical-cancellous bone, or bone-soft tissue interfaces. The drill system has a dental drill handset having a cannula bearing electrically coupled to a drilling bit, the drilling bit having an electrically insulated portion and an exposed portion. The cannula bearing is coupled to an electrical impedance spectroscopy sensing device configured to measure impedance between the cannula bearing of the dental drill handset and a ground plate, and a processing system uses EIS measurements to distinguish when the bit of the drill system approaches cortical- or cancellous bone, or bone-soft tissue interfaces.

Abstract: A dental drill system with electrical-impedance sensing indicates when a bit of the drill system approaches cortical-cancellous bone, or bone-soft tissue interfaces. The drill system has a dental drill handset having a cannula bearing electrically coupled to a drilling bit, the drilling bit having an electrically insulated portion and an exposed portion. The cannula bearing is coupled to an electrical impedance spectroscopy sensing device configured to measure impedance between the cannula bearing of the dental drill handset and a ground plate, and a processing system uses EIS measurements to distinguish when the bit of the drill system approaches cortical- or cancellous bone, or bone-soft tissue interfaces.

Abstract: A system and method for identifying ictal states in a patient, the system including a plurality of sensors for sensing different non-electroencephalographic signals from the patient, and a processing unit. The processing unit has a processor and memory with instructions for classifying data from the plurality of sensors to determine probability of the patient being ictal, when the probability is high asking the patient if the patient is in an ictal state, reporting to a caregivers if the patient is ictal, and updating the classifier based upon sensor data, probability, and the response. The method includes sensing, using a plurality of non-electroencephalographic sensors, determining, using a classifier trained using a training dataset, probability of the patient being in an ictal state, and if probability is high, asking the patient if the patient is in ictal state, logging the occurrence of an ictal state, and updating the classifier.

Abstract: A system and method for identifying ictal states in a patient, the system including a plurality of sensors for sensing different non-electroencephalographic signals from the patient, and a processing unit. The processing unit has a processor and memory with instructions for classifying data from the plurality of sensors to determine probability of the patient being ictal, when the probability is high asking the patient if the patient is in an ictal state, reporting to a caregivers if the patient is ictal, and updating the classifier based upon sensor data, probability, and the response. The method includes sensing, using a plurality of non-electroencephalographic sensors, determining, using a classifier trained using a training dataset, probability of the patient being in an ictal state, and if probability is high, asking the patient if the patient is in ictal state, logging the occurrence of an ictal state, and updating the classifier.

Abstract: The present invention provides heterocyclic derivatives of formula (Ia) which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: A compound of formula (I), or tautomers, or stereoisomers, or solvates, or pharmaceutically acceptable salts thereof, wherein M1, M2, L1, L2, W1, W2, X1, X2, Y1, Y2, A, R5 and R5a are as defined herein for the for treatment of conditions treatable by the blockade of an epithelial sodium channel, particularly conditions benefiting from mucosal hydration.

Abstract: A process and system used for reporting and processing incidents of aggressive, dangerous, and discourteous drivers using Short Message Service (SMS) data, also known as “text messaging” using key words or characters. A hand held electronic device is used to send a text message location reporting emergency or non-emergency information to a central processing unit. By establishing a process and system that utilizes mobile hand held electronic devices or cell phones to report emergency and non-emergency information through text messaging and downloading that information to the central processing unit, this data is then put through a filtration process to allow the most serious road violators and those needing help to be easily retrieved. The information is then transmitted to a subscriber via text message and/or email for corrective action or for dispatching emergency help.