Abstract: A guidewire for use with a catheter has varying radiopacity as well as at least one radiopaque marker in its distal end. In one embodiment, the guidewire includes a shaft that supports a distal radiopaque coil and a proximal radiopaque coil. The proximal and distal coils are spaced apart from one another. The non-radiopaque area between the two coils has at least one radiopaque marker band attached to the shaft. The marker bands provide several radiographically visible reference Lengths. A polymer sleeve encases the marker bands and the shaft between the first and second coils providing a uniform outer diameter to the distal region of the guidewire. In another embodiment, the proximal coil may be omitted. In a further embodiment, a radiopaque coil having varying pitch along its length is supported by and attached to a distal region of the core wire.