Patents by Inventor Rebecca HOLMBERG
Rebecca HOLMBERG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240035067Abstract: An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.Type: ApplicationFiled: July 10, 2023Publication date: February 1, 2024Inventors: Christopher G. COONEY, Rebecca HOLMBERG, Phillip BELGRADER, Peter Qiang QU
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Patent number: 11767549Abstract: An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.Type: GrantFiled: December 30, 2020Date of Patent: September 26, 2023Assignee: AKONNI BIOSYSTEMS, INC.Inventors: Christopher G. Cooney, Rebecca Holmberg, Phillip Belgrader, Peter Qiang Qu
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Publication number: 20230157703Abstract: Apparatus and methods are disclosed for determining and placing a first bony segment in relation with a second bony segment, both segments belonging to the same bone, including cutting said bone partially, to separate it into the first and second bony segment. The two bony segments are linked together by a bony hinge and placing the two boney segments in relation to each other may include distracting both bony segments around said hinge. The hinge may be configured to allow distraction of both bony segments around a single degree of freedom of the hinge and accommodate corrections in two substantially orthogonal planes.Type: ApplicationFiled: January 29, 2021Publication date: May 25, 2023Inventors: Paul Alexander Torrie, Dennis Colleran, Miles Malone, John Albert Slusarz, Jr., Jason Hamilton, Jacob Mercer, Rebecca Holmberg
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Publication number: 20210230668Abstract: An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.Type: ApplicationFiled: December 30, 2020Publication date: July 29, 2021Inventors: Christopher G. COONEY, Rebecca HOLMBERG, Phillip BELGRADER, Peter Qiang QU
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Publication number: 20190078138Abstract: An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells, Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and. analysis of molecules of interest, such as nucleic acids and proteins.Type: ApplicationFiled: October 11, 2018Publication date: March 14, 2019Inventors: Christopher G. COONEY, Rebecca HOLMBERG, Phillip BELGRADER, Peter Qiang QU
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Publication number: 20190010487Abstract: Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a pregnant woman. The method includes flowing the plasma sample through a first filter under conditions that allow binding of the fetal and maternal nucleic acids to the first filter; eluting the fetal and maternal nucleic acids bound to the first filter to produce a concentrated nucleic acid sample; flowing the concentrated nucleic acid sample through a second filter under conditions that allow preferential binding of the maternal nucleic acids to the second filter; and recovering the fetal nucleic acid from the concentrated nucleic acid sample that flow through the second filter.Type: ApplicationFiled: August 22, 2018Publication date: January 10, 2019Inventors: Rebecca Holmberg, Alissa Erin Gindlesperger, Tinsley Janna Stokes, Phillip Belgrader
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Patent number: 10125388Abstract: An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.Type: GrantFiled: December 1, 2015Date of Patent: November 13, 2018Assignee: AKONNI BIOSYSTEMS, INC.Inventors: Christopher G. Cooney, Rebecca Holmberg, Phillip Belgrader, Peter Qiang Qu
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Patent number: 10093919Abstract: Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a pregnant woman. The method includes flowing the plasma sample through a first filter under conditions that allow binding of the fetal and maternal nucleic acids to the first filter; eluting the fetal and maternal nucleic acids bound to the first filter to produce a concentrated nucleic acid sample; flowing the concentrated nucleic acid sample through a second filter under conditions that allow preferential binding of the maternal nucleic acids to the second filter; and recovering the fetal nucleic acid from the concentrated nucleic acid sample that flow through the second filter.Type: GrantFiled: July 20, 2016Date of Patent: October 9, 2018Assignee: Akonni Biosystems, Inc.Inventors: Rebecca Holmberg, Alissa Erin Burkey, Tinsley Janna Stokes, Phillip Belgrader
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Publication number: 20160326516Abstract: Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a pregnant woman. The method includes flowing the plasma sample through a first filter under conditions that allow binding of the fetal and maternal nucleic acids to the first filter; eluting the fetal and maternal nucleic acids bound to the first filter to produce a concentrated nucleic acid sample; flowing the concentrated nucleic acid sample through a second filter under conditions that allow preferential binding of the maternal nucleic acids to the second filter; and recovering the fetal nucleic acid from the concentrated nucleic acid sample that flow through the second filter.Type: ApplicationFiled: July 20, 2016Publication date: November 10, 2016Inventors: Rebecca HOLMBERG, Alissa Erin GINDLESPERGER, Tinsley Janna STOKES, Phillip BELGRADER
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Patent number: 9428746Abstract: Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a pregnant woman. The method includes flowing the plasma sample through a first filter under conditions that allow binding of the fetal and maternal nucleic acids to the first filter; eluting the fetal and maternal nucleic acids bound to the first filter to produce a concentrated nucleic acid sample; flowing the concentrated nucleic acid sample through a second filter under conditions that allow preferential binding of the maternal nucleic acids to the second filter; and recovering the fetal nucleic acid from the concentrated nucleic acid sample that flow through the second filter.Type: GrantFiled: August 27, 2013Date of Patent: August 30, 2016Assignee: Akonni Biosystems, Inc.Inventors: Rebecca Holmberg, Alissa Erin Gindlesperger, Tinsley Janna Stokes, Phillip Belgrader
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Publication number: 20160083781Abstract: An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.Type: ApplicationFiled: December 1, 2015Publication date: March 24, 2016Inventors: CHRISTOPHER G. COONEY, REBECCA HOLMBERG, PHILLIP BELGRADER, PETER QIANG QU
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Publication number: 20140017672Abstract: Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a pregnant woman. The method includes flowing the plasma sample through a first filter under conditions that allow binding of the fetal and maternal nucleic acids to the first filter; eluting the fetal and maternal nucleic acids bound to the first filter to produce a concentrated nucleic acid sample; flowing the concentrated nucleic acid sample through a second filter under conditions that allow preferential binding of the maternal nucleic acids to the second filter; and recovering the fetal nucleic acid from the concentrated nucleic acid sample that flow through the second filter.Type: ApplicationFiled: August 27, 2013Publication date: January 16, 2014Inventors: Rebecca HOLMBERG, Alissa Erin GINDLESPERGER, Tinsley Janna STOKES, Phillip BELGRADER