Patents by Inventor Rebecca Horan
Rebecca Horan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9089501Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: December 20, 2013Date of Patent: July 28, 2015Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Rebecca Horan, David J. Horan, Jingsong Chen
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Patent number: 9066884Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: July 30, 2012Date of Patent: June 30, 2015Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20150104514Abstract: A silk fiber based matrix composition comprising spider silk that can be biodegradable, from the spider species Nephila clavipes (or from genetically engineered bacteria making Nephila clavipes silk), and in the form of a mesh or film.Type: ApplicationFiled: October 15, 2014Publication date: April 16, 2015Inventors: David Kaplan, Gregory H. Altman, Rebecca Horan, David Horan
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Publication number: 20140105951Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: December 20, 2013Publication date: April 17, 2014Applicant: Allergan, Inc.Inventors: Gregory H. Altman, Rebecca Horan, David J. Horan, Jingsong Chen
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Patent number: 8623398Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: GrantFiled: July 30, 2012Date of Patent: January 7, 2014Assignee: Allergan, Inc.Inventors: Gregory H. Altman, Rebecca Horan, David J. Horan, Jingsong Chen
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Publication number: 20120296351Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 22, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120296443Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 22, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120296352Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 22, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120294906Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 22, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120289981Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: July 30, 2012Publication date: November 15, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20120210547Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: April 26, 2012Publication date: August 23, 2012Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20110171453Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: March 24, 2011Publication date: July 14, 2011Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20110167602Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: March 24, 2011Publication date: July 14, 2011Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20100256756Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: April 29, 2010Publication date: October 7, 2010Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David J. Horan
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Publication number: 20100209405Abstract: The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.Type: ApplicationFiled: April 29, 2010Publication date: August 19, 2010Applicant: ALLERGAN, INC.Inventors: Gregory H. Altman, David L. Kaplan, Rebecca Horan, David J. Horan
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Publication number: 20050089552Abstract: The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.Type: ApplicationFiled: November 16, 2004Publication date: April 28, 2005Applicants: Tissue Regeneration, Inc., Trustees of Tufts CollegeInventors: Gregory Altman, David Kaplan, Rebecca Horan, David Horan
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Publication number: 20040224406Abstract: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.Type: ApplicationFiled: March 11, 2004Publication date: November 11, 2004Applicant: Tissue Regeneration, Inc.Inventors: Gregory H. Altman, Jingsong Chen, Rebecca Horan, David Horan