Abstract: There is provided sample analysis cartridges comprising a housing defining a reaction chamber configured to receive a sample, a dry reagent storage chamber, and a fluid reagent storage chamber, and a reagent supply mechanism for selectively supplying reagent from the dry and fluid storage chambers during an analysis, wherein the dry reagent storage chamber comprises a liner formed from a material having a lower fluid permeability than the material from which the housing is formed.

Abstract: A computer implemented method is described herein for post-execution evaluation of a machine-learning (ML) algorithm. The method can include receiving a post-execution version of the ML algorithm having a plurality of behavioral states. The method can include generating behavior identification data identifying a given behavioral state from the plurality of behavioral states of the ML algorithm. The given behavioral state can correspond to a decision-making state of the ML algorithm that the ML algorithm learned during an execution of the ML algorithm. A graphical user interface (GUI) can be generated based on the behavior identification data that includes a behavior object characterizing the given behavioral state of the ML algorithm. Behavior evaluation data can be generated based on a user's interaction with the behavior object. A learning process of the ML algorithm can be altered for future execution of the ML algorithm based on the behavior evaluation data.

Abstract: There is provided a method of detecting the presence of a target polynucleotide and/or sequence variations within the target polynucleotide using a probe system comprising two independent partner oligonucleotide components wherein the first oligonucleotide has a first and second section, wherein the first section comprises a nucleotide sequence that is labelled with at least one visually detectable label and is not capable of hybridising to the nucleotide sequence of the target polynucleotide; and wherein the second section comprises a nucleotide sequence that is capable of hybridising to a portion of the sequence of the target polynucleotide; and the second oligonucleotide has a first and second section, wherein the first section comprises a nucleotide sequence which is capable of hybridising to a nucleotide sequence of the first section of the first oligonucleotide; and the second section comprises a nucleotide sequence that is capable of hybridising to a nucleotide sequence of the target polynucleotide tha

Abstract: A method for determining the number of tandem repeats in a target polynucleotide, the method comprising (a) providing a sample containing the target polynucleotide, wherein one or more of the tandem repeats in the target polynucleotide is in single stranded form, (b) hybridizing a labelled probe oligonucleotide to the single stranded portion of the target polynucleotide, wherein the probe oligonucleotide is complementary to at least one of the tandem repeats, and at least 5 nucleotides of the probe oligonucleotide are complementary to the tandem repeats, in the single stranded portion of the target polynucleotide, and (c) determining the number of tandem repeats in the target polynucleotide based on the hybridization of the probe oligonucleotide to the single stranded portion of the target polynucleotide.

Abstract: A method for determining the number of tandem repeats in a target polynucleotide, the method comprising (a) providing a sample containing the target polynucleotide, wherein one or more of the tandem repeats in the target polynucleotide is in single stranded form, (b) hybridising a labelled probe oligonucleotide to the single stranded portion of the target polynucleotide, wherein the probe oligonucleotide is complementary to at least one of the tandem repeats, and at least 5 nucleotides of the probe oligonucleotide are complementary to the tandem repeats, in the single stranded portion of the target polynucleotide, and (c) determining the number of tandem repeats in the target polynucleotide based on the hybridisation of the probe oligonucleotide to the single stranded portion of the target polynucleotide.