Abstract: The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of an extracellular or cell surface protein. In certain embodiments, the extracellular protein mediates a disease and/or disorder in a subject, and treatment or management of the disease and/or disorder requires degradation, removal, and/or reduction in concentration of the protein in the subject. In some embodiments, the disease and/or disorder is a neurological disease and/or disorder. Thus, in certain embodiments, administration of a compound of the disclosure to the subject removes or reduces the amount of the extracellular or cell surface protein in the brain, thus treating, ameliorating, or preventing the disease and/or disorder.

Abstract: The present disclosure provides, in one aspect, bifunctional compounds that can be used to promote or enhance degradation of an extracellular or cell surface protein. In certain embodiments, the extracellular protein mediates a disease and/or disorder in a subject, and treatment or management of the disease and/or disorder requires degradation, removal, and/or reduction in concentration of the protein in the subject. In some embodiments, the disease and/or disorder is a neurological disease and/or disorder. Thus, in certain embodiments, administration of a compound of the disclosure to the subject removes or reduces the amount of the extracellular or cell surface protein in the brain, thus treating, ameliorating, or preventing the disease and/or disorder.

Abstract: Techniques are described for computing a risk based assignment (RBA) score for a valuation of a target property, and assigning an appraiser to perform the valuation based on the RBA score. The techniques may be used to select appraisers for mortgage loan default or origination. The RBA score is a numerical value used to estimate a level of complexity of the valuation of the target property in a given time. The level of complexity of the valuation is gauged by valuation accuracy, which is influenced by a level of difficulty to select comparable properties. The disclosed techniques comprise a model configured to assess the complexity of the valuation based on property specific information for the target property and generated neighborhood property information associated with a neighborhood of the target property. The techniques ensure that high complexity valuations are assigned to appraisers and valuation tools identified as being highly accurate.

Abstract: The present invention relates generally to a system and method for improving the quality assurance/quality control (QA/QC) of advanced radiation treatment techniques using a patient-specific, multi-material, multi-dimensional anthropomorphic human equivalent phantom technology.