Abstract: The invention discloses a synthesizing method of benzimidazole derivant and intermediate, which is characterized by the following: proceeding arylation among aryl halide and primary amine; adopting L-pro as additive, cuprous iodide as catalyst; proceeding molecular arylation coupling reaction for aryl iodide or aryl bromide and primary amine; adopting iodo phenylamine compound and bromophenylamine compound as starting material; synthesizing the material through several-step transformation.

Abstract: Various embodiments of the teachings herein include a system for automated distribution of a number of predetermined objects in a room and/or on a surface. The system may include: a module for inputting and/or generating data; a module for outputting and/or presenting solutions; and interfaces for transmitting the data to a storage unit connected to a processor configured to carry out a genetic algorithm. The genetic algorithm uses the data and initially provides a generation of solutions. The processor evaluates and selects among the solutions based on their progressiveness then recombines the selected solutions. The procedure repeats and provides the most progressive solutions to an artificial intelligence and/or to a neural network which uses the solutions to generate new rules and transfers the most progressive solutions to the processor for refinement of the algorithm.

Abstract: Various embodiments include computer-aided systems and methods for training a user in conducting negotiations. An example method includes: providing data of a first type using recordings of real or virtual negotiations of one or more users with of one or more recording devices after corresponding computer-aided processing; and communicating the data of a first type to an artificial intelligence for generating data of a second and a third type. Data of a second and a third type are presented on an output device, which give the user a conception of the AI-calculated reaction and/or consequence of the user's recorded negotiation, subsequently and also in real time, during the ongoing negotiation.

Abstract: Various embodiments of the teachings herein include a method for recognizing the emotional tendency of a user recorded over a defined period by two or more recording and/or capture devices. An example method comprises: generating primary data relating to the user for each device; forwarding the primary data to a server; combining the primary data in the server to form respective primary data sets for each device; assigning each primary data set individually to one or more primarily determined emotional tendencies of the user; generating secondary data by logically comparing the primarily determined emotional tendencies which have occurred at the same time; and generating a result in the form of one or more secondary emotional tendencies of the recorded and/or captured user by processing the secondary data.

Abstract: Disclosed herein are chimeric antigen receptors (“CARs”) comprising an antigen binding site that recognizes citrullinated polypeptides. Citrullinated polypeptides, such as citrullinated vimentin, fibrinogen, and filaggrin, are expressed in the synovium of subjects with rheumatoid arthritis. Further disclosed are T cells, and in particular, Treg cells, that express these CARs. Administration of these CAR-T cells is useful in the treatment of rheumatoid arthritis as well as other diseases associated with citrullinated peptides.

Abstract: Various embodiments of the teachings herein include a system for automatically synchronizing and providing data for retrieval by intelligent machines and/or users. For example, the system may include: a computing unit providing a platform; an input and output unit; and an artificial intelligence passively monitoring the input and output unit and learning from the responses, adaptations and/or assessments of the user. The artificial intelligence automatically carries out synchronization, in line with the input, of the various data types, metadata and/or memory levels of the inputs and/or outputs, develops search strategies and/or makes search results available in the output unit.

Abstract: Various embodiments of the teachings housing for a manufacturing machine and/or a part of a production line, the housing comprising a transparent element used at least partially as: a projection surface for a head-up display comprising an optics module and an imaging unit in addition to the projection surface, a carrier for a transparent interactive input device including at least one of: a transparent multitouch element, a sensor button, a slider, a wheel, a trackpad, and a touchscreen, and/or a combiner for augmented and/or assisted reality.

Abstract: Disclosed herein are chimeric antigen receptors (“CARs”) comprising an antigen binding site that recognizes citrullinated polypeptides. Citrullinated polypeptides, such as citrullinated vimentin, fibrinogen, and filaggrin, are expressed in the synovium of subjects with rheumatoid arthritis. Further disclosed are T cells, and in particular, Treg cells, that express these CARs. Administration of these CAR-T cells is useful in the treatment of rheumatoid arthritis as well as other diseases associated with citrullinated peptides.

Abstract: Disclosed herein are chimeric antigen receptors (“CARs”) comprising an antigen binding site that recognizes citrullinated polypeptides. Citrullinated polypeptides, such as citrullinated vimentin, fibrinogen, and filaggrin, are expressed in the synovium of subjects with rheumatoid arthritis. Further disclosed are T cells, and in particular, Treg cells, that express these CARs. Administration of these CAR-T cells is useful in the treatment of rheumatoid arthritis as well as other diseases associated with citrullinated peptides.

Abstract: Systems and methods for generating a virtual reality training session for a procedure to be performed by at least one trainee on a virtual reality (VR) model of a physical object of interest in a technical environment. The method includes the steps of: loading the virtual reality (VR) model of the object of interest from a database into a virtual reality (VR) authoring system; specifying atomic procedural steps of the respective procedure by a technical expert and performing the specified atomic procedural steps in a virtual environment provided by the virtual reality (VR) authoring system by the technical expert on the loaded virtual reality (VR) model of the object of interest; and recording the atomic procedural steps performed by the technical expert in the virtual environment and linking the recorded atomic procedural steps to generate automatically the virtual reality training session stored in the database and available for the trainees.

Abstract: A system for automatically sharing procedural knowledge between domain experts of a technical domain and trainees is provided. The system includes at least one server connected via a communication network to computing devices of the domain experts and computing devices of the trainees.

Abstract: The disclosure relates to a method for displaying a 3D model of an object, wherein the object includes a plurality of parts arranged in original positions. The method includes: actuating a control device by a user to select a selected region of the 3D model, wherein the parts of the object that are located in the selected region form the selected parts; and displaying the 3D model such that the selected parts are displayed in end positions in which they are moved away from their original positions such that distances between the selected parts increase. The selected parts are displayed such that a user may see the selected parts better.

Abstract: The disclosure relates to an interaction system configured to be worn on the human body. The interaction system includes at least one gesture detection unit configured to be mounted in an arm region of a user, a binocular visualization unit for the positionally correct visualization of virtual objects in a visual field of the user, and a control unit for actuating the visualization unit. The gesture control is done intuitively with a motion and/or a rotation of the front arms. An input device, which may be unsuitable in an industrial environment, is thus not required. Due to the wearable character of the interaction system, the user may easily alternate between an actual maintenance procedure an industrial plant and an immersive movement in a virtual model of the industrial plant.

Abstract: A system and method are provided for aligning a field of view (FOV) of a movable part of a medical device with a desired region on a subject's body. In the system, a position detecting unit detects an identifiable optical front projected on the subject's body and at least partially overlapping with the desired region and generates information corresponding to a spatial position of the identifiable optical front. From the information, a processing module determines the spatial position of the identifiable optical front with respect to a known position of the FOV and generates an instruction set that corresponds to one or more mechanical adjustments of the movable part to change a position of the FOV from the known position to the spatial position of the identifiable optical front. An executing module directs a moving mechanism of the movable part to carry out mechanical motions according to the instruction set.

Abstract: Various embodiments may provide an adjustable fit garment that allows the fit of the garment to be adjusted by a user according to the user's preferences. In various embodiments, the garment may be a jacket configured to be worn on an upper body of the user. The jacket may have an outer surface and an inner surface, and a front side and a back side. In various embodiments, one or more zippers may be disposed along the outside surface of the jacket. Each zipper may include two sets of opposing zipper teeth (e.g., first and second sets of zipper teeth) configured to be coupled together. The jacket may further include a gusset coupled between the sets of zipper teeth (e.g., on an interior portion of the zipper) to allow for a limited expansion of the jacket when the zipper is open.

Abstract: The invention features an apparatus, materials and methods for isolating RNA or DNA from a sample.

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.

Abstract: Methods for treating cancer by co-administering a therapeutic monoclonal antibody with IL-21 are described. Exemplary monoclonal antibodies that can be used are rituximab, trastuzumab and anti-CTLA-4 antibodies. The enhanced antitumor of the combination therapy is particularly useful for patient populations that are recalcitrant to monoclonal therapy, relapse after treatment with monoclonal antibodies or where the enhanced IL-21 antitumor effect reduces toxicities associated with treatment using the monoclonal antibodies.