Abstract: A method is disclosed making aluminosilicate SSZ-82. The method includes (1) preparing a reaction mixture comprising: an amorphous alumina source comprising predominantly aluminum hydroxide; an amorphous silica source comprising predominantly colloidal silica; a source of an alkali metal cation; an organic structure directing agent comprising a 1,6-bis(N-cyclohexylpyrrolidinium)hexane dication; hydroxide ions; seed crystals, wherein the seed crystals comprise a crystalline molecular sieve having an SSZ-82 framework; and water; (2) heating the reaction mixture under crystallization conditions including a temperature of from 100° C. to 200° C. for a time sufficient to form crystals of the aluminosilicate zeolite; and (3) recovering at least a portion of the aluminosilicate zeolite from step (2).

Abstract: Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: TROP2 binders and variants thereof are described. In a specific embodiment, the TROP2 binders that are antibodies that preferentially bind high-expressing TROP2 cells over low-expressing TROP2 cells and conjugates thereof comprising the TROP2 binders conjugated to a payload are described.

Abstract: A co-registration system includes a processor circuit that co-registers intravascular data and user annotations to locations along a guidewire shown in an x-ray image. The processor circuit receives, from an x-ray imaging device, x-ray images of a blood vessel while anintravascular catheter moves through the blood vessel along a guidewire. The processor circuit receives, from the catheter, intravascular data representative of the blood vessel while the catheter moves through the blood vessel. The processor circuit co-registers the intravascular data to locations along the guidewire shown in the x-ray image received from the x-ray imaging device. The processor circuit also generates and co-registers annotations such as bookmarks to the guidewire.

Abstract: A laminate includes a first glass article having a first thickness, a first annealing point (TA1), and a first softening point (TS1), a second glass article having a second thickness, a second annealing point (TA2), and a second softening point (TS2), and an interlayer disposed between the first glass article and the second glass article. The first thickness is greater than the second thickness, the second annealing point (TA2) is less than or equal to the first annealing point (TA1), and the second softening point (TS2) is greater than the first softening point (TS1).

Abstract: A method is disclosed for producing small crystal forms of zeolite SSZ-81. The method includes forming a reaction mixture containing an alumina-coated silica sol, a source of an alkali metal, a structure directing agent containing 1,5-bis(N-methylpiperidinium)pentane dications and/or 1,5-bis(1-azonia-bicyclo[2.2.2]octane)pentane dications, a source of hydroxide ions, and water; and subjecting the reaction mixture to crystallization conditions sufficient to form crystals of the zeolite. The compositions made according to that method, as well as the various uses of the compositions, are also disclosed.

Abstract: A co-registration system includes a processor circuit that generates and displays a first co-registration reliability indicator based on the status of an x-ray imaging device and a second co-registration reliability indicator based on the speed of an intravascular catheter/guidewire. The processor circuit receives, from the x-ray imaging device, x-ray images of a blood vessel while the intravascular catheter/guidewire moves through the blood vessel. The processor circuit receives, from the catheter/guidewire, intravascular data representative of the blood vessel while the catheter/guidewire moves through the blood vessel. The processor circuit co-registers the intravascular data to an x-ray image received from the x-ray imaging device. The processor circuit also receives a signal representative of an inactive status of the x-ray imaging device during the movement of the catheter/guidewire.

Abstract: A co-registration system includes a processor circuit that displays one or more intravascular images corresponding to locations along a blood vessel and associated bookmarks within a corresponding x-ray image. The processor circuit receives, from an x-ray imaging device, x-ray images while an intravascular catheter moves through the blood vessel. The processor circuit receives, from the catheter, intravascular data representative of the blood vessel. The processor circuit co-registers the intravascular data to an x-ray image received from the x-ray imaging device. During an imaging phase, the processor circuit generates and displays, based on the coregistered data, bookmarks along the blood vessel. During a later treatment phase, the bookmarks are also displayed in different x-ray images, along with one or more intravascular image corresponding to locations along the blood vessel at which a treatment device is positioned.

Abstract: Implementations of the present application relate to caller previews for video calls. In some implementations, a method includes sending, by a caller device, a call request to a callee device and determining an identifier associated with the callee device. The method determines whether the identifier is associated with an address book of the caller device, and/or is in an outgoing call record of the caller device. An acknowledgment is received from callee device, and, upon receipt of the acknowledgment, a connection is established with the callee device. Based on determining that the identifier is associated with the address book and/or in the outgoing call record, at least a portion of a caller video is transmitted over the connection with the callee device. The caller video is transmitted prior to receipt of an acceptance of the call request from the callee device.

Abstract: Implementations of the present application relate to caller previews for video calls. In some implementations, a method includes sending, by a caller device, a call request to a callee device and determining an identifier associated with the callee device. The method determines whether the identifier is associated with an address book of the caller device, and/or is in an outgoing call record of the caller device. An acknowledgment is received from callee device, and, upon receipt of the acknowledgment, a connection is established with the callee device. Based on determining that the identifier is associated with the address book and/or in the outgoing call record, at least a portion of a caller video is transmitted over the connection with the callee device. The caller video is transmitted prior to receipt of an acceptance of the call request from the callee device.

Abstract: Implementations of the present application relate to caller previews for video calls. In some implementations, a method includes sending, by a caller device, a call request to a callee device and determining an identifier associated with the callee device. The method determines whether the identifier is associated with an address book of the caller device, and/or is in an outgoing call record of the caller device. An acknowledgment is received from callee device, and, upon receipt of the acknowledgment, a connection is established with the callee device. Based on determining that the identifier is associated with the address book and/or in the outgoing call record, at least a portion of a caller video is transmitted over the connection with the callee device. The caller video is transmitted prior to receipt of an acceptance of the call request from the callee device.

Abstract: This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.

Abstract: This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.

Abstract: This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.

Abstract: This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels.