Patents by Inventor Rebecca Powell

Rebecca Powell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODIES
    Publication number: 20230127347
    Abstract: Provided is an anti-TNF-? antibody comprising a sequence modification that inhibits presentation of the antibody by human leukocyte antigen (HLA) molecules. The anti-TNF-? antibody may be infliximab or a fragment or variant thereof. In this case, the modification is suitably one that inhibits presentation of the antibody by DRB1*03:01, such as a modification in the region corresponding to residues 1 to 21 of SEQ ID NO: 1, or a modification in the region corresponding to residues 145 to 159 of SEQ ID NO: 1. Alternatively, the anti-TNF-? antibody may be adalimumab or a fragment or variant thereof. In this case, the modification may be one that inhibits presentation of the antibody by DQA1*05:05/DQB1*03:01. Also provided are nucleic acid sequences that encode an antibody according to the invention, and pharmaceutical composition comprising an antibody or nucleic acid sequence of the invention.
    Type: Application
    Filed: April 1, 2021
    Publication date: April 27, 2023
    Inventors: Rebecca POWELL DOHERTY, Nicola TERNETTE, Jack SATSANGI
  • METHODS FOR PURIFICATION OF MESSENGER RNA
    Publication number: 20220170061
    Abstract: The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
    Type: Application
    Filed: October 11, 2021
    Publication date: June 2, 2022
    Inventors: Joseph Parella, Kimberly Gillis, Jonathan Abysalh, Travis Jeannotte, Erik Held, Frank DeRosa, Michael Heartlein, Rebecca Powell
  • Methods for purification of messenger RNA
    Patent number: 11174500
    Abstract: The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: November 16, 2021
    Assignee: Translate Bio, Inc.
    Inventors: Joseph Parella, Kimberly Gillis, Jonathan Abysalh, Travis Jeannotte, Erik Held, Frank DeRosa, Michael Heartlein, Rebecca Powell
  • METHODS FOR PURIFICATION OF MESSENGER RNA
    Publication number: 20200095571
    Abstract: The present invention provides, among other things, methods for purifying mRNA based on normal flow filtration for therapeutic use.
    Type: Application
    Filed: August 26, 2019
    Publication date: March 26, 2020
    Inventors: Joseph Parella, Kimberly Gillis, Jonathan Abysalh, Travis Jeannotte, Erik Held, Frank DeRosa, Michael Heartlein, Rebecca Powell