Patents by Inventor Rebecca Tayler COTTMAN

Rebecca Tayler COTTMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ERT2 MUTANTS AND USES THEREOF
    Publication number: 20240150433
    Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 9, 2024
    Inventors: Michelle Elizabeth Hung, Rebecca Tayler Cottman, Russell Morrison Gordley, Gary Lee, Timothy Kuan-Ta Lu, Srinivasaraghavan Kannan, Chandra Shekhar Verma
  • DRUG-REGULATABLE TRANSCRIPTIONAL REPRESSORS
    Publication number: 20240141364
    Abstract: Provided herein are chimeric polypeptides for drug-regulated transcriptional repression. Also provided are methods of inhibiting repression of a gene of interest.
    Type: Application
    Filed: October 6, 2023
    Publication date: May 2, 2024
    Inventors: Michelle Elizabeth Hung, Rebecca Tayler Cottman, Russell Morrison Gordley
  • ERT2 MUTANTS AND USES THEREOF
    Publication number: 20240131159
    Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
    Type: Application
    Filed: October 4, 2023
    Publication date: April 25, 2024
    Inventors: Michelle Elizabeth Hung, Rebecca Tayler Cottman, Russell Morrison Gordley, Gary Lee, Timothy Kuan-Ta Lu, Srinivasaraghavan Kannan, Chandra Shekhar Verma
  • INDUCIBLE CELL DEATH SYSTEMS
    Publication number: 20230405144
    Abstract: Provided herein are compositions and methods for inducing cell death in a regulated manner, for example in a safety switch system. Inducible cell death can be triggered by ligand binding to a one or more ligand binding domains. Cell death can include induction of apoptosis.
    Type: Application
    Filed: May 18, 2023
    Publication date: December 21, 2023
    Inventors: Rocky CHEUNG, Russell Morrison GORDLEY, Timothy Kuan-Ta LU, Michelle Elizabeth HUNG, Rebecca Tayler COTTMAN
  • METHODS FOR INCREASING EFFICIENCY OF NUCLEASE-INDUCED HOMOLOGY-DIRECTED REPAIR
    Publication number: 20210292795
    Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).
    Type: Application
    Filed: May 26, 2021
    Publication date: September 23, 2021
    Inventors: J. Keith JOUNG, Benjamin KLEINSTIVER, Jason Michael GEHRKE, Shengdar TSAI, James ANGSTMAN, Rebecca Tayler COTTMAN
  • CCCTC-binding factor variants
    Patent number: 11041155
    Abstract: Described herein are engineered CCCTC-binding factor (CTCF) variants that can bind to mutant CTCF binding sequences and method of using the same.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: June 22, 2021
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Rebecca Tayler Cottman
  • Methods for increasing efficiency of nuclease-induced homology-directed repair
    Patent number: 11021718
    Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: June 1, 2021
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Benjamin Kleinstiver, Jason Michael Gehrke, Shengdar Tsai, James Angstman, Rebecca Tayler Cottman
  • CCCTC-Binding Factor Variants
    Publication number: 20210102213
    Abstract: Described herein are engineered CCCTC-binding factor (CTCF) variants that can bind to mutant CTCF binding sequences and method of using the same.
    Type: Application
    Filed: December 10, 2020
    Publication date: April 8, 2021
    Inventors: Rebecca Tayler Cottman, J. Keith Joung
  • Targetable 3`-Overhang Nuclease Fusion Proteins
    Publication number: 20200248156
    Abstract: Described herein are zinc finger and dCas9 nuclease fusion proteins and methods of using the same for enhancing repair frequencies at the site of a nuclease-induced double strand breaks (DSB) for use in genome editing.
    Type: Application
    Filed: January 31, 2020
    Publication date: August 6, 2020
    Inventors: J. Keith Joung, Rebecca Tayler Cottman
  • METHODS FOR INCREASING EFFICIENCY OF NUCLEASE-INDUCED HOMOLOGY-DIRECTED REPAIR
    Publication number: 20180230494
    Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).
    Type: Application
    Filed: October 1, 2015
    Publication date: August 16, 2018
    Inventors: J. Keith JOUNG, Benjamin KLEINSTIVER, Jason Michael GEHRKE, Shengdar TSAI, James ANGSTMAN, Rebecca Tayler COTTMAN