Patents by Inventor Rebecca Zuckerman

Rebecca Zuckerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20180111929
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: May 25, 2017
    Publication date: April 26, 2018
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, James Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20160176865
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: July 13, 2015
    Publication date: June 23, 2016
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, James Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20150290205
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: January 21, 2015
    Publication date: October 15, 2015
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, Jianming Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20130303534
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: March 5, 2013
    Publication date: November 14, 2013
    Inventors: PRABHA N. IBRAHIM, DEAN R. ARTIS, RYAN BREMER, GASTON HABETS, SHUMEYE MAMO, MARIKA NESPI, CHAO ZHANG, JIAZHONG ZHANG, YONG-LIANG ZHU, REBECCA ZUCKERMAN, BRIAN WEST, YOSHISA SUZUKI, JIANMING TSAI, KLAUS-PETER HIRTH, GIDEON BOLLAG, WAYNE SPEVAK, HANNA CHO, SAMUEL J. GILLETTE, GUOXIAN WU, HONGYAO ZHU, SHENGHUA SHI
  • PDE4B inhibitors and uses therefor
    Patent number: 8470821
    Abstract: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: June 25, 2013
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Hanna Cho, Bruce England, Sam Gillette, Dean R. Artis, Rebecca Zuckerman, Chao Zhang
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 8415469
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: April 9, 2013
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, Jianming Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20120053177
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 1, 2012
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, James Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • PPAR ACTIVE COMPOUNDS
    Publication number: 20120015966
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 19, 2012
    Inventors: Jack Lin, Byunghun Lee, Shenghua Shi, Chao Zhang, Dean R. Artis, Prabha N. Ibrahim, Weiru Wang, Rebecca Zuckerman
  • Compounds and methods for development of Ret modulators
    Patent number: 8067434
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: November 29, 2011
    Assignee: Plexxikon Inc.
    Inventors: Prabha Ibrahim, Dean Richard Artis, Ryan Bremer, Gaston Habets, Clarence R. Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • PPAR active compounds
    Patent number: 8053463
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?, wherein the compounds have the formula: wherein: X2 and X3 are independently CH or N; and one of X1 and X4 is N or CR4 and the other of X1 and X4 is N or CH.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: November 8, 2011
    Assignee: Plexxikon Inc.
    Inventors: Jack Lin, Byunghun Lee, Shenghua Shi, Chao Zhang, Dean R. Artis, Prabha N. Ibrahim, Weiru Wang, Rebecca Zuckerman
  • COMPOUNDS MODULATING C-KIT AND C-FMS ACTIVITY AND USES THEREFOR
    Publication number: 20110166174
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
    Type: Application
    Filed: December 1, 2010
    Publication date: July 7, 2011
    Inventors: Chao Zhang, Jiazhong Zhang, Prabha N. Ibrahim, Clarence R. Hurt, Rebecca Zuckerman, Dean R. Artis, Ryan Bremer, Wayne Spevak, Guoxian Wu, Hongyao Zhu
  • Compounds and methods for development of Ret Modulators
    Publication number: 20100324065
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: April 11, 2008
    Publication date: December 23, 2010
    Inventors: Prabha Ibrahim, Dean Richard Artis, Ryan Bremer, Gaston Habets, Clarence R. Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • Compounds modulating c-kit and c-fms activity and uses therefor
    Patent number: 7846941
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or condition and c-fms-mediated diseases or condition, and methods for the use thereof.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: December 7, 2010
    Assignee: Plexxikon, Inc.
    Inventors: Chao Zhang, Jiazhong Zhang, Prabha N. Ibrahim, Clarence R. Hurt, Rebecca Zuckerman, Dean R. Artis, Ryan Bremer, Wayne Spevak, Guoxian Wu, Hongyao Zhu
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20100256365
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: November 10, 2009
    Publication date: October 7, 2010
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, James Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • PDE4B INHIBITORS AND USES THEREFOR
    Publication number: 20090286793
    Abstract: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
    Type: Application
    Filed: July 20, 2009
    Publication date: November 19, 2009
    Inventors: Prabha N. Ibrahim, Hanna Cho, Bruce England, Sam Gillette, Dean R. Artis, Rebecca Zuckerman, Chao Zhang
  • PDE4B inhibitors
    Patent number: 7605168
    Abstract: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: October 20, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Sam Gillette, Hanna Cho, Marika Nespi, Shumeye Mamo, Chao Zhang, Dean R. Artis, Byunghun Lee, Rebecca Zuckerman
  • PDE4B inhibitors and uses therefor
    Patent number: 7585859
    Abstract: Compounds active on phosphodiesterase PDE4B are provided. Also provided herewith are compositions useful for treatment of PDE4B-mediated diseases or conditions, and methods for the use thereof.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: September 8, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Prabha N. Ibrahim, Hanna Cho, Bruce England, Sam Gillette, Dean R. Artis, Rebecca Zuckerman, Chao Zhang
  • PPAR active compounds
    Patent number: 7531568
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: May 12, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Jack Lin, Dean R. Artis, Prabha N. Ibrahim, Chao Zhang, Rebecca Zuckerman, Ryan Bremer, Shenghua Shi, Byunghun Lee
  • Compounds and methods for development of Ret modulators
    Patent number: 7504509
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: March 17, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Prabha Ibrahim, Dean Richard Artis, Ryan Bremer, Gaston Habets, Clarence R. Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • PPAR ACTIVE COMPOUNDS
    Publication number: 20080255201
    Abstract: Compounds are described that are active on at least one of PPAR?, PPAR?, and PPAR?, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPAR?, PPAR?, and PPAR?.
    Type: Application
    Filed: March 5, 2008
    Publication date: October 16, 2008
    Inventors: Jack Lin, Byunghun Lee, Shenghua Shi, Chao Zhang, Dean R. Artis, Prabha N. Ibrahim, Weiru Wang, Rebecca Zuckerman