Patents by Inventor Rebekah L. Gundry

Rebekah L. Gundry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for selective inhibition of pluripotent stem cells
    Patent number: 11959096
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: April 16, 2024
    Assignees: The Medical College of Wisconsin, Inc., The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services NIH, Office of Technology Transfer
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
  • Multiple Myeloma Mapping and Uses Thereof
    Publication number: 20230280344
    Abstract: The present invention provides methods and kits for detecting and treating multiple myeloma. The methods involve detecting proteins that the inventors have identified as biomarkers of multiple melanoma.
    Type: Application
    Filed: July 15, 2021
    Publication date: September 7, 2023
    Inventors: Jeffrey A. Medin, Robyn A. Oldham, Mary L. Faber, Rebekah L. Gundry
  • Cardiomyocyte-Specific Biological Markers and Uses Thereof
    Publication number: 20220196661
    Abstract: The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection and isolation of in vitro differentiated cardiomyocytes. In particular, the present invention relates to LSMEM2 biomarkers, including monoclonal antibodies having specificity for cell surface protein LSMEM2 and to methods of using such biomarkers for diagnosis of cardiovascular injury.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 23, 2022
    Inventor: Rebekah L. Gundry
  • METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS
    Publication number: 20210017489
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Application
    Filed: September 18, 2020
    Publication date: January 21, 2021
    Applicant: THE MEDICAL COLLEGE OF WISCONSIN, INC.
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
  • Methods for selective inhibition of pluripotent stem cells
    Patent number: 10808222
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: October 20, 2020
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
  • METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS
    Publication number: 20190300847
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Application
    Filed: May 16, 2019
    Publication date: October 3, 2019
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
  • Methods for selective inhibition of pluripotent stem cells
    Patent number: 10316287
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: June 11, 2019
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp
  • Cardiomyocyte-Specific Biological Markers and Uses Thereof
    Publication number: 20180188268
    Abstract: The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection and isolation of in vitro differentiated cardiomyocytes. In particular, the present invention relates to LSMEM2 biomarkers, including monoclonal antibodies having specificity for cell surface protein LSMEM2 and to methods of using such biomarkers for diagnosis of cardiovascular injury.
    Type: Application
    Filed: June 22, 2016
    Publication date: July 5, 2018
    Inventor: Rebekah L. GUNDRY
  • METHODS FOR SELECTIVE INHIBITION OF PLURIPOTENT STEM CELLS
    Publication number: 20160340642
    Abstract: Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
    Type: Application
    Filed: January 21, 2015
    Publication date: November 24, 2016
    Inventors: Rebekah L. Gundry, Kenneth R. Boheler, Erin M. Kropp