Patents by Inventor Rebekka Nicol

Rebekka Nicol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions relating to MEK5 and cardiac hypertrophy and dilated cardiomyopathy
    Publication number: 20050261187
    Abstract: The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its role molecular events that lead to or contribute to cardiac hypertrophy and/or dilated cardiomyopathy. In particular, inhibition of MEK5 activity will lead to decrease signalling of the pathways and reduce or eliminate the effects on sarcomere assembly, which in turn result or contribute to cardiac dysfunction. Also provided are transgenic animals and methods of screening for inhibitors of MEK5.
    Type: Application
    Filed: March 24, 2005
    Publication date: November 24, 2005
    Inventors: Eric Olson, Rebekka Nicol
  • Transgenic mice comprising a constitutively-activated MEK5 and exhibiting cardiac hypertrophy and dilated cardiomyopathy
    Patent number: 6924415
    Abstract: The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its role molecular events that lead to or contribute to cardiac hypertrophy and/or dilated cardiomyopathy. In particular, inhibition of MEK5 activity will lead to decrease signalling of the pathways and reduce or eliminate the effects on sarcomere assembly, which in turn result or contribute to cardiac dysfunction. Also provided are transgenic animals and methods of screening for inhibitors of MEK5.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: August 2, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Eric N. Olson, Rebekka Nicol
  • Methods and compositions relating to MEK5 and cardiac hypertrophy and dilated cardiomyopathy
    Publication number: 20030144176
    Abstract: The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its role molecular events that lead to or contribute to cardiac hypertrophy and/or dilated cardiomyopathy. In particular, inhibition of MEK5 activity will lead to decrease signalling of the pathways and reduce or eliminate the effects on sarcomere assembly, which in turn result or contribute to cardiac dysfunction. Also provided are transgenic animals and methods of screening for inhibitors of MEK5.
    Type: Application
    Filed: May 30, 2002
    Publication date: July 31, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Eric N. Olson, Rebekka Nicol