Patents by Inventor Recaldo Carty

Recaldo Carty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of conjugating oligomeric compounds
    Patent number: 11400161
    Abstract: Provided herein are solid phase methods for the synthesis of conjugated oligomeric compounds and intermediates used in such methods. In particular, the solid phase methods provide for addition of a phosphoramidite functionalized conjugate group to a solid support bound oligomeric compound. The methods also provide an increase in overall yield and a cost benefit over existing methods.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: August 2, 2022
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Isaiah E. Cedillo, Recaldo Carty
  • METHOD OF CONJUGATING OLIGOMERIC COMPOUNDS
    Publication number: 20210283263
    Abstract: Provided herein are solid phase methods for the synthesis of conjugated oligomeric compounds and intermediates used in such methods. In particular, the solid phase methods provide for addition of a phosphoramidite functionalized conjugate group to a solid support bound oligomeric compound. The methods also provide an increase in overall yield and a cost benefit over existing methods.
    Type: Application
    Filed: October 6, 2017
    Publication date: September 16, 2021
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Isaiah E. Cedillo, Recaldo Carty
  • Oligonucleotide synthesis with alternative solvents
    Patent number: 7276599
    Abstract: The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5? blocked-nucleoside, deblocking the 5? blocked-nucleoside to form a 5? OH-nucleoside, coupling the 5? OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: October 2, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Max N. Moore, Mark Andrade, Recaldo Carty, Anthony Scozzari, Achim Krotz
  • Oligonucleotide synthesis with alternative solvents
    Publication number: 20050026192
    Abstract: The invention provides for methods of manufacturing an oligonucleotide comprising a pentavalent phosphate triester. In particular, the method comprises providing a 5? blocked-nucleoside, deblocking the 5? blocked-nucleoside to form a 5? OH-nucleoside, coupling the 5? OH-nucleoside with a phosphoramidite to form and oligonucleotide comprising a trivalent phosphite triester; and oxidizing the oligonucleotide comprising a trivalent phosphite triester to the oligonucleotide comprising a pentavalent phosphate triester. In some embodiments, the wash between any of the steps above is with at least one solvent wash comprising a toluene.
    Type: Application
    Filed: June 2, 2004
    Publication date: February 3, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Max Moore, Mark Andrade, Recaldo Carty, Anthony Scozzari, Achim Krotz