Patents by Inventor Reda Rawi

Reda Rawi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST WESTERN, EASTERN, AND VENEZUELAN EQUINE ENCEPHALITIS VIRUS (EEV)
    Publication number: 20260199447
    Abstract: Disclosed herein are isolated antibodies that bind one or more species of alphaviruses. In certain aspects, the disclosed antibodies bind and neutralize three or more species of alphaviruses. Also disclosed are methods of using the disclosed antibodies to prevent infection of a cell with an alpha virus, to protect an individual from alphavirus infection, and to treat an individual for an alphavirus infection.
    Type: Application
    Filed: December 7, 2023
    Publication date: July 16, 2026
    Inventors: Mario Roederer, Sungyoul Ko, Matthew Scott Sutton, Peter D. Kwong, Raffaello Verardi, Reda Rawi, Chen-Hsiang Shen, Julie Fox, Victoria Callahan, Gabriele Cerutti, Ryan Gavin Casner, Lawrence Shapiro, Yaroslav Tsybovsky, Sergei Pletnev
  • BASE-COVERED HIV-1 ENVELOPE ECTODOMAINS AND THEIR USE
    Publication number: 20250197455
    Abstract: Immunogens comprising a soluble HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and comprising modifications to introduce N-linked glycan sequons at the membrane-proximal base of the trimer, as well as methods of their use and production are disclosed. In several implementations, the immunogen can be used to elicit an immune response to HIV-1 in a subject.
    Type: Application
    Filed: March 27, 2023
    Publication date: June 19, 2025
    Applicant: TThe United States of America, as represented by the Secretary, Department of Health and Human Servi
    Inventors: Peter Kwong, Tongqing Zhou, Adam Olia, Reda Rawi, Anita Shah, Darcy Harris, Ridhi Chaudhary, Cheng Cheng, Yongping Yang
  • NEUTRALIZING ANTIBODIES TO PLASMODIUM FALCIPARUM CIRCUMSPOROZOITE PROTEIN AND THEIR USE
    Publication number: 20250011406
    Abstract: Antibodies and antigen binding fragments that specifically bind to P. falciparum circumsporozoite protein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit a P. falciparum infection.
    Type: Application
    Filed: November 4, 2022
    Publication date: January 9, 2025
    Applicants: The USA, as represented by the Secretary, Department of Health and Human Services, The General Hospital Corporation
    Inventors: Young Do Kwon, Amarendra Pegu, Eun Sung Yang, Peter Kwong, Robert Seder, Facundo Batista, Sven Kratochvil, Chen-Hsiang Shen, Reda Rawi, Mateo Reveiz, Prabhanshu Tripathi
  • ANTIBODY-GUIDED PCSK9-MIMICKING IMMUNOGENS LACKING 9-RESIDUE SEQUENCE OVERLAP WITH HUMAN PROTEINS
    Publication number: 20240299510
    Abstract: The present disclosure describes the grafting of epitope residues from human PCSK9 to non-human PCSK9 or PCSK9 structural homologs and elimination of 9-mers oligopeptides that are found in human protein to reduce self-targeting response. Anti-genicity of the epitope-scaffold constructs was demonstrated toward anti-human PCSK9 antibodies. similar to wild type human PCSK9. It was shown that disclosed PCSK9 immunogens could significantly reduce LDL and cholesterol levels in immunized mice.
    Type: Application
    Filed: December 31, 2021
    Publication date: September 12, 2024
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Peter D. Kwong, Gwo-Yu Chuang, Baoshan Zhang, Wing-Pui Kong, Yiran Wang, Cara Chao, John R. Mascola, Li Ou, Tongqing Zhou, Yongping Yang, Bohan Liu, Cheng Cheng, Daniel W. Biner, Reda Rawi