Abstract: A novel system, apparatus, composition and method provide facile collection of a physical sample, including in particular noninvasive extraction of buccal cells, specifically directed to capture of PCR-ready DNA from such cheek cells. It is particularly useful in achieving simplified collection, transit, processing and storage of biological samples with minimal chain of custody.

Abstract: An apparatus and method for treatment of end stage renal decline and failure through peritoneal dialysis enabling ambulatory transfer of dialysate to and from the peritoneum of a renal patient, this in synthesis and coordination with normal physiological rhythms of the patient. The system remains unobtrusive and less restrictive of patient ambulation and orientation. The present invention includes expendables disposability of which facilitates safe reuse of more expensive portions and is sufficiently simple for use in a home care environment. It may be designed to incorporate real-time, interactive or remote monitoring and regulation and visual or audible indication of system pressures, chemical balances and other important variables.

Abstract: A manifold assembly useful in patient ventilation/aspiration systems includes a stop cock valve with a hollow stem and a transverse slot arranged to permit the stem to be rotated between open and closed positions. In both positions, a ventilating pathway is maintained through the slot and the stem between ventilator and patient connection ports of the manifold. In open position the stem provides a travel pathway for a catheter between the patient connection port and an access port of the manifold. In closed condition, the stem seals this travel pathway. Catheter depth finding features and internally walled manifold structure for direction of respiratory therapy fluids particularly useful for neonatal patients are presented.

Abstract: A novel system, apparatus, composition and method provide facile collection of a physical sample, including in particular noninvasive extraction of buccal cells, specifically directed to capture of PCR-ready DNA from such cheek cells. It is particularly useful in achieving simplified collection, transit, processing and storage of biological samples with minimal chain of custody.

Abstract: An apparatus and method for treatment of end stage renal decline and failure through peritoneal dialysis enabling ambulatory transfer of dialysate to and from the peritoneum of a renal patient, this in synthesis and coordination with normal physiological rhythms of the patient. The system remains unobtrusive and less restrictive of patient ambulation and orientation. The present invention includes expendables disposability of which facilitates safe reuse of more expensive portions and is sufficiently simple for use in a home care environment. It may be designed to incorporate real-time, interactive or remote monitoring and regulation and visual or audible indication of system pressures, chemical balances and other important variables.

Abstract: A pump assembly for ambulatory peritoneal dialysis transfer procedures includes a portable power supply geared to drive a high-volume peristaltic pump. A cassette of the pump comprises an encasement; tubing including an inner portion positioned within the encasement, a patient-side portion for connection to an indwelling peritoneal dialysis catheter and an opposing portion connectable to a system for containment and communication of a peritoneal dialysis solution which may be one single-compartment bag assembly; a safety valve for selectively occluding and permitting the communication of the solution through the inner portion; and a filter preferably interposed along the patient-side portion which filters air and particles from peritoneal dialysate that is flowing toward a patient and which allows peritoneal dialysate to flow substantially freely and unfiltered away from the patient.

Abstract: A pump assembly for ambulatory peritoneal dialysis transfer procedures includes a portable power supply geared to drive a high-volume peristaltic pump. A cassette of the pump comprises an encasement; tubing including an inner portion positioned within the encasement, a patient-side portion for connection to an indwelling peritoneal dialysis catheter and an opposing portion connectable to a system for containment and communication of a peritoneal dialysis solution which may be one single-compartment bag assembly; a safety valve for selectively occluding and permitting the communication of the solution through the inner portion; and a filter preferably interposed along the patient-side portion which filters air and particles from peritoneal dialysate that is flowing toward a patient and which allows peritoneal dialysate to flow substantially freely and unfiltered away from the patient.

Abstract: A manifold assembly useful in patient ventilation/aspiration systems includes a stop cock valve with a hollow stem and a transverse slot arranged to permit the stem to be rotated between open and closed positions. In both positions, a ventilating pathway is maintained through the slot and the stem between ventilator and patient connection ports of the manifold. In open position the stem provides a travel pathway for a catheter between the patient connection port and an access port of the manifold. In closed condition, the stem seals this travel pathway.

Abstract: A sealed ventilation circuit interface system, which enables simultaneous patient ventilation and safe tracheal suctioning, is structured to accommodate any of a wide variety of commercially available suction catheters. The interface system comprises a manifold assembly, and an adaptor. The manifold assembly may be attached to a patient for an extended period, while the adaptor is advantageously constructed as a single procedural use disposable device. The adaptor couples with the manifold assembly, and may be configured to effect the introduction of a catheter through a normally closed valve structure carried by the manifold assembly. The adaptor may alternatively be configured to interface the manifold with a bronchoscope or other appliance. A vacuum valve assembly biased in an open position is selectively actuated between open and closed positions and can be locked in a closed position. The vacuum valve remains at either position without ongoing manual pressure.