Patents by Inventor Reem K. Arafa

Reem K. Arafa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyridines as antiparasitic AZA teraryl compounds
    Patent number: 8188121
    Abstract: Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. The compounds include those of Formula (III): wherein one of A1, Y1, and Z1 is N; Ar1 is phenylene; and Ar3 is a nitrogen-containing aromatic group.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: May 29, 2012
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
    Inventors: Richard R. Tidwell, David W. Boykin, W. David Wilson, Reto Brun, Karl Werbovetz, Mohamed A. Ismail, Reem K. Arafa, Laixing Hu
  • Linear dicationic terphenyls and their aza analogues as antiparasitic agents
    Patent number: 8101636
    Abstract: Novel aza analogues of dicationic terphenyl compounds for use in combating microbial infections are described. Also described are processes for synthesizing the compounds.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: January 24, 2012
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
    Inventors: Richard R. Tidwell, David W. Boykin, W. David Wilson, Reto Brun, Karl Werbovetz, Mohamed A. Ismail, Reem K. Arafa
  • NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS
    Publication number: 20110257199
    Abstract: Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.
    Type: Application
    Filed: June 17, 2011
    Publication date: October 20, 2011
    Inventors: Richard R. Tidwell, David W. Boykin, W. David Wilson, Reto Brun, Karl Werbovetz, Mohamed A. Ismail, Reem K. Arafa, Laixing Hu
  • Teraryl components as antiparasitic agents
    Patent number: 7964619
    Abstract: Disclosed herein are novel dicationic teraryl compounds and their aza analogues, including compounds of Formula (IIe): wherein p and q are each 0 and each A, Y and Z is CR4. An exemplary compound of Formula (IIe) is: Methods for combating microbial infections, such as parasitic Leishmania species, with novel dicationic terphenyl compounds and their aza analogues are included. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues are disclosed along with methods for evaluation of the compounds as potential anti-protozoan agents.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: June 21, 2011
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
    Inventors: Richard R. Tidwell, David W. Boykin, W. David Wilson, Reto Brun, Laixing Hu, Karl Werbovetz, Mohamed A. Ismail, Reem K. Arafa
  • Fused ring dicationic anti-protozoan agents and their prodrugs
    Patent number: 7825279
    Abstract: Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: November 2, 2010
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
    Inventors: David W. Boykin, Richard R. Tidwell, W. David Wilson, Reto Brun, Reem K. Arafa, Chad E. Stephens