Abstract: The present application provides flexible radio frequency (RF) assemblies, components thereof and related methods. The present application includes at least one flexible substrate comprising first and second sides, a flexible framework portion comprising a first material composition and a plurality of discrete spaced interior portions comprising second material compositions that differ from that of the flexible framework portion. The framework portion extends fully about a portion of each interior portion. The framework portion comprises a flexibility that is greater than that of the interior portions. Each interior portion and the framework portion comprise a dielectric constant, a loss tangent, a volume resistivity, a surface resistivity and a magnetic relative permeability. At least one of the dielectric constant, the loss tangent, the volume resistivity, the surface resistivity and the magnetic relative permeability of at least one of the interior portions differs from that of the framework portion.