Abstract: The present invention provides subcutaneous pharmaceutical injectable compositions comprising ketamine or its salt such as Ketamine Hydrochloride equivalent to Ketamine base 50 mg/ml and stabilizer. The invention further provides a method for preparing the said compositions. Compositions of the present invention depict a typical pharmacokinetic profile. Compositions of the present invention are bioequivalent to currently marketed injectable compositions but have lower Cmax, similar Tmax and similar AUC. Compositions of the present invention are useful in treatment of treatment resistant depression and in management of pain.

Abstract: The present invention provides a stable aqueous composition of Methisoprinol. In particular, it provides a stable aqueous injectable composition comprising 25 to 150 mg/ml of Methisoprinol, at least one alcohol, and at least one excipient selected from pH modifier or buffer, surfactant, solvents, co-solvent, preservative, antioxidants, chelating agent and a tonicity modifier. The alcohol is present in proportion up to 40% w/v, preferably up to 30% w/v. The invention also provides methods of preparation of such composition and uses thereof in the treatment or prevention of viral diseases and immune suppressed states.

Abstract: Techniques and mechanisms for transparently transitioning an interconnect fabric between a first frequency and a second frequency. In an embodiment, the fabric is coupled to an end point device via an asynchronous device. One or more nodes of the fabric operate in a first clock domain based on a clock signal, while the end point device operates in a different clock domain. Controller circuitry changes a frequency of the clock signal by stalling the clock signal throughout a first period of time which is greater than a duration of three cycles of a lower one of the first frequency or the second frequency. After the first period of time, cycling of the clock signal is provided at the second frequency. In another embodiment, the asynchronous device enables the frequency change without preventing communication with the end point device.

Abstract: Techniques and mechanisms for transparently transitioning an interconnect fabric between a first frequency and a second frequency. In an embodiment, the fabric is coupled to an end point device via an asynchronous device. One or more nodes of the fabric operate in a first clock domain based on a clock signal, while the end point device operates in a different clock domain. Controller circuitry changes a frequency of the clock signal by stalling the clock signal throughout a first period of time which is greater than a duration of three cycles of a lower one of the first frequency or the second frequency. After the first period of time, cycling of the clock signal is provided at the second frequency. In another embodiment, the asynchronous device enables the frequency change without preventing communication with the end point device.

Abstract: Techniques and mechanisms for transparently transitioning an interconnect fabric between a first frequency and a second frequency. In an embodiment, the fabric is coupled to an end point device via an asynchronous device. One or more nodes of the fabric operate in a first clock domain based on a clock signal, while the end point device operates in a different clock domain. Controller circuitry changes a frequency of the clock signal by stalling the clock signal throughout a first period of time which is greater than a duration of three cycles of a lower one of the first frequency or the second frequency. After the first period of time, cycling of the clock signal is provided at the second frequency. In another embodiment, the asynchronous device enables the frequency change without preventing communication with the end point device.

Abstract: This disclosure presents various means for securing a tracking beacon to personal protection equipment. The tracking beacon mount is constructed of a cover, a base, a transmitter and a mounting mechanism, such as a strap. The transmitter has a unique identifier which is detected by a proximity sensor. The proximity sensor is operably connected to a tracking system which can be used to detect the presence of the beacons. The system is programmed to recognize the types of items used and warn the user if something predetermined as required for the location or job type is missing.

Abstract: An asset tracking system includes a series of sensors placed on a tool storage system connected to a computerized system. The sensor mounts are placed so that sensor can detect the presence or absence of the tool assigned to the spot. In some examples, these sensors are pressure sensors calibrated to detect the weight of the tool upon the tool mount. The system can remotely notify a user of the status of the tools through either a display or a telecommunications system. The system can also be configured in some examples to check tools out to a specific user via the computerized system.

Abstract: This disclosure presents various means for securing a tracking beacon to personal protection equipment. The tracking beacon mount is constructed of a cover, a base, a transmitter and a mounting mechanism, such as a strap. The transmitter has a unique identifier which is detected by a proximity sensor. The proximity sensor is operably connected to a tracking system which can be used to detect the presence of the beacons. The system is programmed to recognize the types of items used and warn the user if something predetermined as required for the location or job type is missing.

Abstract: Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.

Abstract: Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.

Abstract: Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.

Abstract: A shipping and display carton convertible into a cover portion and display tray is described comprised of a cover portion formed from a cover blank and a tray portion formed from a tray blank. The blanks are preferably glued together at only three glue points when the tray blank is laid flat on top of the cover blank in order to form a two-layered blank that may be erected into the present carton. The fully erected carton may be easily broken apart into an attractive display tray and a disposable/recyclable cover by gripping the cover within a grasping aperture and lifting the cover portion up to break the carton apart at the two side tabs and along the rear of the carton.

Abstract: Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.

Abstract: A shipping and display carton convertible into a cover portion and display tray is described comprised of a cover portion formed from a cover blank and a tray portion formed from a tray blank. The blanks are preferably glued together at only three glue points when the tray blank is laid flat on top of the cover blank in order to form a two-layered blank that may be erected into the present carton. The fully erected carton may be easily broken apart into an attractive display tray and a disposable/recyclable cover by gripping the cover within a grasping aperture and lifting the cover portion up to break the carton apart at the two side tabs and along the rear of the carton.

Abstract: Compositions containing uricase are disclosed. Methods of treating a disorder associated with elevated uric acid concentrations using uricase are also described. Compositions containing uricase and catalase are also disclosed. Methods of treating a disorder associated with elevated uric acid concentrations using uricase and catalase are also described.

Abstract: Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. Additionally disclosed are methods of producing protein crystals.