Abstract: A sealing element for wellbore operations can include an energizing end with a sloped surface and a perpendicular surface, a stationary end with a sloped surface and a perpendicular surface, and an engagement surface located between the energizing end and the stationary end. An energizing sleeve can include a sloped surface that engages with and moves along the sloped surface of the energizing end to cause the engagement surface to engage with the inside of a tool housing, casing, or tubing string to create a seal. A stationary tool component can about the stationary end, so the sealing element is energized. The sealing element can be used in a packer assembly, as an anchoring device, in lieu of O-rings, to allow opening or closing of flow ports, or in other downhole tools.

Abstract: Float collar equipment can be bonded to an inside of a casing string via an adhesive. An annulus can be located around an outside of a float collar housing and the inside of the casing string where the adhesive can be injected. The float collar housing does not require external threads or packers to secure the housing to the inside of the casing string. An injection sub can be used to inject the adhesive into the annulus. After curing or drying, the adhesive bonds the housing to the casing string. A seat, seat housing, or float shoe nose can be attached to the float collar housing via an adhesive or threads. The float collar housing can house one or more float assemblies. The float collar equipment can be bonded to the casing string at a wellsite or remote location prior to use in a cementing operation.

Abstract: Methods of treatment and pharmaceutical formulation configured to improve the cure rate of patients with solid tumors when treated with radiotherapy are provided. The methods and treatments use an inhibitor of the CXCL12/CXCR4 pathway. The inhibitors prevent the formation of new blood vessels into a tumor that is being treated with radiotherapy. The inhibitor may be continuously infused intravenously towards the end of radiotherapy and continuing thereafter.

Abstract: A downhole retrieval tool for engaging and retrieving an object from a wellbore includes a mandrel and a grapple having a contracted position and an expanded position. In the expanded position, the grapple engages the object for retrieval. The grapple is operably associated with an expansion member disposed on the mandrel to facilitate movement of the grapple between the contracted and expanded positions. The expansion member is releasably connected to the mandrel. In the event that the downhole tool and object, once secured to each other, are unable to be retrieved from the wellbore, the expansion member can be released from the mandrel which, in turn, causes the grapple to release from the object so that the downhole tool can be removed from the wellbore. A stored energy member facilitates movement of the grapple from the contracted position to the expanded position.

Abstract: A downhole retrieval tool for engaging and retrieving an object from a wellbore includes a mandrel and a grapple having a contracted position and an expanded position. In the expanded position, the grapple engages the object for retrieval. The grapple is operably associated with an expansion member disposed on the mandrel to facilitate movement of the grapple between the contracted and expanded positions. The expansion member is releasably connected to the mandrel. In the event that the downhole tool and object, once secured to each other, are unable to be retrieved from the wellbore, the expansion member can be released from the mandrel which, in turn, causes the grapple to release from the object so that the downhole tool can be removed from the wellbore. A stored energy member facilitates movement of the grapple from the contracted position to the expanded position.

Abstract: A milling bottom hole assembly (BHA) for use in cutting a full gauge window in a wellbore casing wall, the resultant length of the window being greater than or equal to the whipstock ramp length. A milling BHA is described which includes two shaft portions, a window mill and two bearing mills. The design, which involves strategically placed bearing mills, allows the milling BHA to stay on the whipstock ramp for the entire casing window milling operation and, thereafter, to optimally rapidly build angle and move laterally away from the whipstock and casing, creating a significantly long window which allows for easy passage of directional drilling BHAs through the milled window.