Patents by Inventor Reeta Mehta
Reeta Mehta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5965158Abstract: A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.Type: GrantFiled: November 26, 1997Date of Patent: October 12, 1999Assignees: The University of Texas System & Board of Regents, Aronex Pharmaceuticals, Inc.Inventors: Robert P. Link, Reeta Mehta, Gabriel Lopez-Berestein
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Patent number: 5830498Abstract: A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.Type: GrantFiled: September 28, 1995Date of Patent: November 3, 1998Assignees: Board of Regents, The University of Texas System, Aronex Pharmaceuticals, Inc.Inventors: Robert P. Lenk, Reeta Mehta, Gabriel Lopez-Berestein
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Patent number: 5178875Abstract: A method is disclosed for preparing a stable preliposomal powder which, when reconstituted with water or saline solution, forms a suspension of liposomes containing a polyene drug, such as nystatin. The method involves the steps of combining at least one phospholipid with a first organic solvent to form a first solution, adding a clarifying amount of water to the first solution, combining a polyene with a second organic solvent to form a second solution, combining the first and second solutions to produce a substantially clear combined solution, and then removing the organic solvents, leaving a powder.Type: GrantFiled: January 14, 1991Date of Patent: January 12, 1993Assignee: The Board of Regents, The University of Texas SystemInventors: Robert P. Lenk, Reeta Mehta, Gabriel Lopez-Berestein
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Patent number: 5032404Abstract: The present invention involves a liposomal agent for treating disseminated fungal infection in an animal. This liposomal agent comprises a variety of polymer antifungal compounds, particularly hamycin. These antifungal compounds are encapsulated within a liposome decreasing toxicity. This liposome is preferably a stable multilamellar vesicle. The method of administration is preferably parenteral, but may be oral or topical.Type: GrantFiled: February 23, 1989Date of Patent: July 16, 1991Assignee: Board of Regents, The University of Texas SystemInventors: Gabriel Lopez-Berestein, Reeta Mehta
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Patent number: 4981690Abstract: The present invention involves a liposomal agent for treating disseminated fungal infection in an animal. This liposomal agent comprises the polyene antifungal compound mepartricin. The mepatricin is encapsulated within a liposome. The liposome in which the mepartricin is incorporated is preferably a stable multilamellar vesicle. The liposome broadly comprises one or more lipids one or more of phosphomonoglyceride, phosphatidic acid and sphingolipid. The lipids are preferably one or more of phosphatidylcholine, phosphatidylserine, phosphatidylglycerol, sphingomyelin or phosphatidic acid. The lipids are most preferably one or more of dimyristoylphosphatidylchlorine, dimyristoylphosphatidylglycerol, phosphatidylcholine and phosphatidylglycerol. The liposome of the present invention may comprise a sterol most preferably cholesterol. An important aspect of the present invention involves a method for treating disseminated fungal infection in an animal.Type: GrantFiled: October 27, 1987Date of Patent: January 1, 1991Assignee: Board of Regents, The University of Texas SystemInventors: Gabriel Lopez-Berestein, Reeta Mehta, Roy L. Hopfer, Rudolph L. Juliano
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Patent number: 4978654Abstract: A method is disclosed for treatment of disseminated fungal infection in a mammal comprising the administration of a fungicidally effective amount of Amphotericin B encapsulated in a substantially sterol-free liposome to the infected mammal. Also provided is an agent for treatment of disseminated fungal infection in a mammal comprising Amphotericin B encapsulated in a liposome which consists essentially of lipids other than sterols.Type: GrantFiled: January 12, 1987Date of Patent: December 18, 1990Assignee: Board of Regents, The University of Texas SystemInventors: Gabriel Lopez-Berestein, Victor Fainstein, Evan M. Hersh, Roy L. Hopfer, Rudolph L. Juliano, Kapil Mehta, Reeta Mehta
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Patent number: 4950432Abstract: The present invention involves a process for producing fine powder suitable for the preparation of antifungal polyene microlide-containing liposomes upon suspension in an aqueous solution. This process comprises the following steps. Quantities of polyene macrolide and phospholipids are dissolved respectively in a first solvent and a second solvent to form a first solution and a second solution. The first solution and the second solution are mixed in a desired ratio to form a mixture. The first solvent and the second solvent are then removed from the mixture, for example by evaporation, to form a residue. The residue is then dissolved in a third solvent comprising tertiary butanol and methylene chloride to form a third solution. The third solvent is then removed from the third solution to form a remnant. The remnant is then dissolved in a solvent consisting essentially of tertiary butanol to form a fourth solution. The fourth solution is then filtered through a filter having orifices of between about 0.Type: GrantFiled: October 16, 1987Date of Patent: August 21, 1990Assignee: Board of Regents, The University of Texas SystemInventors: Reeta Mehta, Gabriel Lopez-Berestein
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Patent number: 4812312Abstract: The present invention involves a liposomal agent for treating disseminated fungal infection in an animal. This liposomal agent comprises the polyene antifungal compound nystatin. The nystatin is encapsulated within a liposome. The liposome in which the nystatin is incorporated is preferably a stable multilamellar vesicle. The liposome broadly comprises one or more lipids one or more of phosphomonoglyceride, phosphatidic acid and sphingolipid. The lipids are preferably one or more of phosphatidylcholine, phosphatidylserine, phosphatidylglycerol, sphingomyelin or phosphatidic acid. The lipids are most preferably one or more of dimyristoylphosphatidylcholine, dimyristoylphosphatidylglycerol, phosphatidylcholine and phosphatidylglycerol. The liposome of the present invention may comprise a sterol most preferably cholesterol. An important aspect of the present invention involves a method for treating disseminated fungal infection in an animal.Type: GrantFiled: March 3, 1987Date of Patent: March 14, 1989Assignee: Board of Regents of the University of Texas SystemInventors: Gabriel Lopez-Berestein, Reeta Mehta, Roy L. Hopfer, Rudolph L. Juliano
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Patent number: 4663167Abstract: Method for treatment of disseminated fungal infection in a mammal comprising the administration of a fungicidally effective amount of Amphotericin B encapsulated in a substantially sterol-free liposome to the infected mammal. Also provided is an agent for treatment of disseminated fungal infection in a mammal comprising liposome-encapsulated Amphotericin B, said liposome being comprised of lipids other than sterols.Type: GrantFiled: April 16, 1984Date of Patent: May 5, 1987Assignee: The Board of Regents of the University of Texas SystemInventors: Gabriel Lopez-Berestein, Victor Fainstein, Evan M. Hersh, Roy L. Hopfer, Rudolph L. Juliano, Kapil Mehta, Reeta Mehta