Abstract: Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenoxy- and substituted-phenoxy alcohols, carbamates, aminoalcohols, carbamoylalcohols, oxazolidinones, pyrrolidines, thiosemicarbazides and aminoalkylacetamides. The compounds act systemically to ameliorate gastric bleeding otherwise caused by aspirin.

Abstract: Novel pharmaceutical methods, combinations and compositions for reducing gastric bleeding during aspirin therapy for inflammation are disclosed. Compounds used in combination with aspirin are phenylalkylamines and phenylalkylureas having the formula: ##STR1## wherein Z is selected from the group consisting of --NHR.sup.2 or ##STR2## and R is selected from the group consisting of hydrogen, halogen, lower-alkoxy and trifluoromethyl and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen and lower-alkyl, where R.sup.3 and R.sup.4 taken together with the adjacent nitrogen atom may form a heterocyclic ring selected from the group of piperidino, pyrrolidino, piperazino, and morpholino.

Abstract: Methods of treating symptomatic conditions of inflammation due to chronic and acute rheumatic and degenerative joint disease with a combination of indomethacin or phenylbutazone and a phenoxymethyl-2-oxazolidinone resulting in beneficial reduction in side effects of ulceration and bleeding in the lower intestinal tract normally associated with indomethacin and phenylbutazone and compositions containing the combination are disclosed.